Reproduction and Breast Cancer Risk

Hanf, Volker; Hanf, Dorothea

doi:10.1159/000369570

Cited by 17 publications

(8 citation statements)

References 53 publications

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“…Breast feeding has consistently been associated with lower risk of breast cancer in epidemiological studies. 39 Other reproductive factors such as older age at menarche might also associate with risk, possibly depending on the breast cancer subtype 40 A weakness in our study was that we were unable to adjust for reproductive factors other than parity and number of births; if such factors were associated with change in alcohol intake, results could be biased due to residual confounding.…”

Section: Discussionmentioning

confidence: 97%

Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study

Dam

Hvidtfeldt

Tjønneland

et al. 2016

BMJ

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Objective To test the hypothesis that postmenopausal women who increase their alcohol intake over a five year period have a higher risk of breast cancer and a lower risk of coronary heart disease compared with stable alcohol intake.Design Prospective cohort study.Setting Denmark, 1993-2012.Participants 21 523 postmenopausal women who participated in the Diet, Cancer, and Health Study in two consecutive examinations in 1993-98 and 1999-2003. Information on alcohol intake was obtained from questionnaires completed by participants.Main outcome measures Incidence of breast cancer, coronary heart disease, and all cause mortality during 11 years of follow-up. Information was obtained from the Danish Cancer Register, Danish Hospital Discharge Register, Danish Register of Causes of Death, and National Central Person Register. We estimated hazard ratios according to five year change in alcohol intake using Cox proportional hazards models.Results During the study, 1054, 1750, and 2080 cases of breast cancer, coronary heart disease, and mortality occurred, respectively. Analyses modelling five year change in alcohol intake with cubic splines showed that women who increased their alcohol intake over the five year period had a higher risk of breast cancer and a lower risk of coronary heart disease than women with a stable alcohol intake. For instance, women who increased their alcohol intake by seven or 14 drinks per week (corresponding to one or two drinks more per day) had hazard ratios of breast cancer of 1.13 (95% confidence interval 1.03 to 1.23) and 1.29 (1.07 to 1.55), respectively, compared to women with stable intake, and adjusted for age, education, body mass index, smoking, Mediterranean diet score, parity, number of births, and hormone replacement therapy. For coronary heart disease, corresponding hazard ratios were 0.89 (0.81 to 0.97) and 0.78 (0.64 to 0.95), respectively, adjusted for age, education, body mass index, Mediterranean diet score, smoking, physical activity, hypertension, elevated cholesterol, and diabetes. Results among women who reduced their alcohol intake over the five year period were not significantly associated with risk of breast cancer or coronary heart disease. Analyses of all cause mortality showed that women who increased their alcohol intake from a high intake (≥14 drinks per week) to an even higher intake had a higher mortality risk that women with a stable high intake.Conclusion In this study of postmenopausal women over a five year period, results support the hypotheses that alcohol intake is associated with increased risk of breast cancer and decreased risk of coronary heart disease.

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Section: Discussionmentioning

confidence: 97%

Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study

Dam

Hvidtfeldt

Tjønneland

et al. 2016

BMJ

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“…Other risk factors are related to hormones, including early age of menarche, late onset of menopause, nulliparity, late age of first parity, lactation, use of oral contraceptive and hormone replacement therapy (6,7). Moreover, various life style-related factors, such as alcohol consumption and obesity, and disease conditions (e.g., diabetes), also contribute to the occurrence of breast cancer (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis

Bishayee

Mandal

Bhattacharyya

et al. 2015

Nutrition and Cancer

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Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of its various health benefits. This study was initiated to investigate chemopreventive potential of a pomegranate emulsion (PE) against 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis. The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. PE dose-dependently suppressed cell proliferation and induced apoptosis in mammary tumors. Immunohistochemical studies showed that PE increased intratumor Bax, decreased Bcl2 and manifested a proapoptotic shift in Bax/Bcl2 ratio. In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. Thus, PE exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of Bax and downregulation of Bcl2 in concert with caspase cascades. Pomegranate bioactive phytoconstituents could be developed as a chemopreventive drug to reduce the risk of breast cancer.

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“…The hypothesis that prolonged lactation protects against the development of BC is one of the oldest and the most enduring hypotheses concerning the etiology of this neoplasm. Age at menarche and BC risk are probably indirectly associated, research estimate that the risk of BC can be reduced 10-20% for each year menarche is delayed, the results of a large study revealed that for each two-year delay in one set of menstruation, BC risk was reduced by about 10% (36) . In this study, most of the cases (55.9%) were started menstruation between the age of 13-14 years old and only 17.6% started menarche at earlier age.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in a Sample of Yemeni Female Patients: Forensic Dermatoglyphic Traits and Clinico-Pathological Features

Thabit¹,

Abdullah²,

Alnoban³

2019

IraqiJMS

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Background:Breast cancer has a major impact on health of women worldwide and Yemen is not in exception. Fingerprints play an important role, which is highly individualistic and could be recognized as a powerful tool in diagnosis of various diseases, furthermore, their medico-legal importance. Objective:To study the clinico-pathological aspects of breast cancer and the role of fingerprints as screening test. Methods:Prospective study of 68 female patients with breast cancer came to modern histopathology laboratory - Aden during the period from January - June 2018. All the patients suffering from breast lumps were referred for Fine Needle Aspiration Cytology diagnosis as well as fingerprints of their both hands were taken. Results:Most of the participants (45.6%) aged between 40-49 years old, females from urban areas consisted 57.4%, and about 51.5% of females in this study were illiterate. Females who had 1-3 child consisted 33.8%. Regarding the breast lump, 54.4% of females had tumor size 2-5 cm, while skin change and fixed tumor to skin presented in same rate (14.8%). No pain and no nipple discharge present in 85.2% and 91.2% respectively in females' study. The females with palpable axillary lymph nodes and right breast side tumor consisted the same percentage (58.8%). Regarding the result of fine needle aspiration cytology, the invasive ductal carcinoma presented with high rate (85.3%), while stage II present with 36.8%. In relation to the finger print patterns; the loop patterns presented high rate in the little digit with 30.4%, while whorls patterns presented in index digit in 33.6% of patients. The loops and whorls patterns revealed significant association with breast cancer with a P-value of 0.005 and 0.028 respectively. Conclusion:The social, behavioral, and hereditary factors play an important role in the development of breast cancer in addition to reproductive history, beside that the fingerprints are genetically determined factors that can be used as simple and cost-effective screening test for breast cancer. Keywords:Breast carcinoma, fingerprints, Dermatoglyphic, forensic, Yemeni female. Citation:Bin Thabit MA, Abdullah NA, Alnoban MS. Breast Cancer in a sample of Yemeni female patients: forensic dermatoglyphic traits and clinico-pathological features. Iraqi JMS. 2019; 17(2): 135-145. doi: 10.22578/IJMS.17.2.7

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Reproduction and Breast Cancer Risk

Cited by 17 publications

References 53 publications

Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study

Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: prospective cohort study

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis

Breast Cancer in a Sample of Yemeni Female Patients: Forensic Dermatoglyphic Traits and Clinico-Pathological Features

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