Reproducible Simulation of Respiratory Motion in Porcine Lung Explants

Biederer, Jürgen; Plathow, Christian; Schöebinger, Max; Tetzlaff, Ralf; Puderbach, Michael; Bolte, Hendrik; Zaporozhan, J.; Meinzer, Hans Peter; Heller, Martin; Kauczor, HU

doi:10.1055/s-2006-927149

Cited by 24 publications

(22 citation statements)

References 16 publications

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“…For simulation of infiltrates, 50 ml of diluted agarose gel was instilled into the bronchial system of the contralateral lung during reinflation. During the MRI, the lungs were ventilated at 8/min by a diaphragmatic pump; for details, see [22]. For the purpose of correlation and documentation of simulated lesions, helical CT of all phantoms was performed using a tube voltage of 120 kV and a tube current of 560 mA (64-slice CT; Somatom Sensation 64, Siemens Medical Solutions, Forchheim, Germany).…”

Section: Phantom Experimentsmentioning

confidence: 99%

MRI of respiratory dynamics with 2D steady-state free-precession and 2D gradient echo sequences at 1.5 and 3 Tesla: an observer preference study

et al. 2008

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To compare the image quality of dynamic lung MRI with variations of steady-state free-precession (SSFP) and gradient echo (GRE) cine techniques at 1.5 T and 3 T. Ventilated porcine lungs with simulated lesions inside a chest phantom and four healthy human subjects were assessed with SSFP (TR/TE=2.9/1.22 ms; 3 ima/s) and GRE sequences (TR/TE=2.34/0.96 ms; 8 ima/s) as baseline at 1.5 and 3 T. Modified SSFPs were performed with nine to ten images/s (parallel imaging factors 2 and 3). Image quality for representative structures and artifacts was ranked by three observers independently. At 1.5 T, standard SSFP achieved the best image quality with superior spatial resolution and signal, but equal temporal resolution to GRE. SSFP with improved temporal resolution was ranked second best. Further acceleration (PI factor 3) was of no benefit, but increased artifacts. At 3 T, GRE outranged SSFP imaging with high lesion signal intensity, while artifacts on SSFP images increased visibly. At 1.5 T, a modified SSFP with moderate parallel imaging (PI factor 2) was considered the best compromise of temporal and spatial resolution. At 3 T, GRE sequences remain the best choice for dynamic lung MRI.

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Section: Phantom Experimentsmentioning

confidence: 99%

MRI of respiratory dynamics with 2D steady-state free-precession and 2D gradient echo sequences at 1.5 and 3 Tesla: an observer preference study

et al. 2008

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“…Für schnittbildgeführte Navigationen am Schädel unter freier Kopfbewegung deuten sich zumindest Lösungsansätze an[23]. Biederer et al haben ein Phantom entwickelt, welches im MRT reproduzierbar Atembewegungen an Tierlungen simuliert[24]. Wenn dieses Phantom CT-kompatibel ist, kann es auch zur Prüfung von Navigationssystemen am CT eingesetzt werden.…”

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Vergleich zweier Navigationshilfen für CT-gesteuerte Interventionen unter besonderer Berücksichtigung der Nutzungseigenschaften der verwendeten Systeme

Schulz¹,

Röttger²,

Bahner-Heyne³

et al. 2009

Fortschr Röntgenstr

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In the overall assessment of the handling of the systems, PatPos Invent was determined to be easier to comprehend and to provide greater conformity with expectations. With regard to the self-descriptive capacity and usability, PinPoint was assessed more positively. Both systems enable safe puncturing at all degrees of difficulty. The weak point of both systems is the failure to take patient movement into account.

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“…The phantom experiment used a diaphragmatic pump for the exactly reproducible ventilation of animal lung explants inside a dedicated porcine chest phantom [5]. Before CT scanning 8 markers were injected into the left and right lung, respectively 4 markers in each side.…”

Section: Resultsmentioning

confidence: 99%

Finite Element Simulation of Moving Targets in Radio Therapy

Remmert

Biederer

et al.

Bildverarbeitung Für Die Medizin 2007

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Abstract. Among other options, radiotherapy plays an increasing role for the treatment of lung cancer. This has raised the need for strategies to compensate for respiratory motion of the target. Sophisticated techniques such as tracking of the tumour position have become feasible. However, calculations for adequate dose delivery to moving targets with maximum preservation of healthy tissue require understanding the principle of soft tissue deformation In this paper, we introduce a new approach using non-linear finite element method to simulate lung tissue displacement during respiration. The geometric non-linearity and the material non-linearity were applied. The respiration movement was regarded as steady gradual process with equal velocity, and was simulated statically. Boundary condition was set on lung's surface, and the deformation of whole volume could be calculated. Simulation of diaphragm breathing was compared with 4DCT of ventilated porcine lung inside a chest phantom. The average difference of internal point movement was 3 mm vertically. Our vision is to integrate the concept of FEM simulation of respiratory motion into motion adapted radiotherapy planning.

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Reproducible Simulation of Respiratory Motion in Porcine Lung Explants

Abstract: The chest phantom with a diaphragmatic pump is a promising platform for multi-modality imaging studies of the effects of respiratory lung motion.

Cited by 24 publications

References 16 publications

MRI of respiratory dynamics with 2D steady-state free-precession and 2D gradient echo sequences at 1.5 and 3 Tesla: an observer preference study

MRI of respiratory dynamics with 2D steady-state free-precession and 2D gradient echo sequences at 1.5 and 3 Tesla: an observer preference study

Vergleich zweier Navigationshilfen für CT-gesteuerte Interventionen unter besonderer Berücksichtigung der Nutzungseigenschaften der verwendeten Systeme

Finite Element Simulation of Moving Targets in Radio Therapy

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