Reproducible metacarpal joint space width measurements using 3D analysis of images acquired with high-resolution peripheral quantitative computed tomography

Barnabe, Cheryl; Buie, Helen R.; Kan, Michelle; Szabó, Éva; Barr, Susan G.; Martin, Liam; Boyd, Steven K.

doi:10.1016/j.medengphy.2013.04.003

Cited by 32 publications

(24 citation statements)

References 25 publications

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“…State-of-the-art high-resolution peripheral quantitative computed tomography (HR-pQCT) is a sensitive tool used in the assessment of metacarpophalangeal (MCP) joints to describe joint space width (JSW), erosion number and size as well as bone density and microarchitecture with high precision (8)(9)(10)(11). JSW outcomes are calculated volumetrically using an operator-independent algorithm (12) and are minimally sensitive to positioning (13).…”

Section: Introductionmentioning

confidence: 99%

The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography

Manske

Brunet²,

Finzel³

et al. 2019

J Rheumatol

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Objective.We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.Methods.In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.Results.Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.Conclusion.HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.

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Section: Introductionmentioning

confidence: 99%

The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography

Manske

Brunet²,

Finzel³

et al. 2019

J Rheumatol

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“…6 Thirdly, a 3D assessment of joint space is described using quantitative analysis algorithms. 12,13 Fourthly, 3D measurement of bone microarchitecture in rheumatoid arthritis patients showed altered results with disease …”

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confidence: 99%

High-resolution peripheral quantitative CT in rheumatology

et al. 2015

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CORRESPONDENCEWe read with interest the Perspectives article by Filippucci et al. (Progress in imaging in rheumatology. Nat. Rev. Rheumatol. 10, 628-634;. 1 This article is a very informative concise paper on MRI and musculoskeletal ultrasono graphy. However, we were surprised that no mention was made of high-resolution peripheral quantitative CT (HR-pQCT), previously highlighted in a Review in this journal, 2 and we would like to call attention to its emerging potential in the field of advanced diagnostic imaging.HR-pQCT was initially developed to study bone diseases such as osteoporosis, and has contributed to a better understanding of the separate behavior of trabecular and cortical bone structures and the different cortical envelopes during ageing, in metabolic bone diseases and during fracture healing; 2 moreover, it allows for calculation of bone strength in vivo using finite-element analysis. 3 Due to its ability to evaluate bone in 3D at a high resolution (82 μm) and with minimal irradiation (5 μSv to image a 0.9 cm region of interest), HR-pQCT is being intensely investigated in the evaluation of bone architecture in the small joints of the hands in rheumatoid arthritis, 4-6 psori atic arthritis, 7 and hand osteoarthritis. 8 To what degree can this method now be rated as "progress in imaging" in rheumatology?Firstly, an increased number of, and earlier stages of, erosions are visible with HR-pQCT than on plain radiography, as evidenced by the work of Stach et al. 4 Secondly, quantification of erosions in terms of size (width, depth and volume) together with changes in trabecular bone is possible, and has been studied in crosssectional and longitudinal studies 5,9-11 and in comparison with MRI. 6 Thirdly, a 3D assessment of joint space is described using quantitative analysis algorithms. 12,13 Fourthly, 3D measurement of bone microarchitecture in rheumatoid arthritis patients showed altered results with disease High-resolution peripheral quantitative CT in rheumatologyCheryl Barnabe, Stephanie Finzel, Kathryn S. Stok and Piet Geusens activity. 14 None of these 3D parameters can currently be evaluated by other imaging techniques at such high resolution.In conclusion, HR-pQCT is, besides MRI and musculoskeletal ultrasonography, also promising "progress in imaging" for clinical research in rheumatic disease of the hand joints. SPECTRA (Study Group for X-treme CT in Rheumatoid Arthritis) 15 is an inter national collaboration between rheumatologists, radiologists, biomedical engineers, physicists and clinical researchers in bone metabolism and osteoimmunology that has provided fertile ground for crossdisciplinary research, united by the desire to certify the validity of the research findings from the application of this technology to the assessment of inflammatory arthritis.

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“…Radiographic measurements of JSW for rheumatoid arthritis have similar limitations, leading some to develop more reliable positioning protocols and automated means of measurement using 3D CT imaging. [16] Because the JSW assessment used in our study was based upon the distribution of JSW over the whole joint, it was summarized as the percentage of the tibiofemoral area below each threshold for JSW. The reliability of this areal percentage, including approximately 30,000 JSW measurements per compartment, cannot be directly compared with the reliability for a single minimal JSW measurement on a 2D image such as a radiograph.…”

Section: Discussionmentioning

confidence: 99%

Test–retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

et al. 2016

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Objective To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging. Subjects and Methods This prospective two-visit study included 50 knees from 30 subjects (66% female; mean ±SD age 58.2 ± 11.3 years; BMI 29.1 ± 5.6 kg/m2; 38% KL grade 0–1). Tibiofemoral geometry was obtained from bilateral approximately 20° fixed-flexed SCT images acquired at visits two weeks apart. For each compartment, the total joint area was defined as the area with a JSW <10mm. The summary measurements of interest were the percent of the total joint area with a JSW less than 0.5mm thresholds between 2.0mm–5.0mm in each tibiofemoral compartment. Test-retest reliability of the summary JSW measurements was assessed by Intraclass Correlation Coefficients (ICC 2,1) for the percent area engaged at each threshold of JSW and root-mean-square errors (RMSE) were calculated to assess reproducibility. Results The ICC were excellent for each threshold assessed, ranging from 0.95–0.97 for the lateral and 0.90–0.97 for the medial compartment. RMSE ranged from 1.1–7.2% for the lateral and from 3.1–9.1% for the medial compartment, with better reproducibility at smaller thresholds of JSW. Conclusion The knee joint positioning protocol used demonstrated high day-to-day reliability for SCT 3D tibiofemoral JSW summary measurements repeated 2 weeks apart. Low-dose SCT provides a great deal of information about the joint while maintaining high reliability, making it a suitable alternative to plain radiographs for evaluating JSW in people with knee OA.

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Reproducible metacarpal joint space width measurements using 3D analysis of images acquired with high-resolution peripheral quantitative computed tomography

Cited by 32 publications

References 25 publications

The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography

The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography

High-resolution peripheral quantitative CT in rheumatology

Test–retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

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