Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

Dyas, A.; Wise, R.; Pijck, J.; Hallynck, Th.; Acar, J. F.; Adam, Dieter; Cadórniga, R; Wenk, Markus R.; Soep, H.

doi:10.1093/jac/12.4.371

Cited by 3 publications

(4 citation statements)

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“…These direct comparisons of the aminoglycoside antibiotics serve as the basis for the following discussion. The preponderance of evidence indicates that tobramycin and gentamicin serum or plasma pharmacokinetics are nearly identical (Regamcy et al, 1973;Carbon et al, 1978;Dyas et al, 1983) although tobramycin reaches less than one-third of the interstitial fluid concentrations that gentamkin does in rabbits. However, tobramycin accumulates much less than gentamicin in the renal cortex (Whelton et al, 1978), with cortex: serum .…”

Section: Comparison Of the Pharmacokinetics Of Various Aminoglycosidesmentioning

confidence: 99%

“…Penetration of netilmicin into interstitial fluid is intermediate between gentamicin and tobramycin (Carbon et al, 1978). Amikacin, although dosed at a higher rate because of a lower antimicrobial potency than most other aminoglycosides, has a slightly shorter t,h than gentamicin or tobramycin (Carbon et al, 1978;Wise et al, 1981;Dyas et al, 1983). due principally to its smaller V d (Dyas el al., 1983).…”

Section: Comparison Of the Pharmacokinetics Of Various Aminoglycosidesmentioning

confidence: 99%

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Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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Section: Comparison Of the Pharmacokinetics Of Various Aminoglycosidesmentioning

confidence: 99%

Section: Comparison Of the Pharmacokinetics Of Various Aminoglycosidesmentioning

confidence: 99%

Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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“…The half-life in camels was 164-215 min (harmonic mean, 188 min). which was longer than the half-life of the drug reported in humans (98-129 min: Regamey et al, 1973: Dyas et al, 1983), dogs (70-80 min: Szwed et al, 1974 and cats (70-1 10 min: Jernigan et al, 1988). This would suggest that the glomerular filtration rate is lower in hydrated camels than in humans, dogs and cats.…”

Section: Discussionmentioning

confidence: 72%

“…The pharmacokinetics of tobramycin have been determined in humans (Regamey et al, 1973;Dyas et al, 1983), dogs (Szwed et al. 1974) and cats (Jernigan et al, 1988).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of tobramycin in the camel

Hadi

Wasfi²,

Gadir

et al. 1994

Vet Pharm & Therapeutics

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The pharmacokinetics of tobramycin were determined in six healthy camels (Camelus dromedarius) following the intravenous (i.v.) and intramuscular (i.m.) administration of single doses of tobramycin sulphate (40 mg/ml). The half-life to tobramycin was 189 +/- 21 min and the mean residence time was 254 +/- 26 min. The apparent volume of distribution (area method) was 245 +/- 21 ml/kg, while volume of the central compartment of the two-compartment pharmacokinetic model was 110 +/- 12 ml/kg. The clearance (systemic) of tobramycin was 0.90 +/- 0.10 ml/min/kg. Values of the pharmacokinetic parameters suggest that glomerular filtration rate is lower in camels than in other ruminant species, horses, dogs and cats. Following i.m. administration of the dose (1.0 mg/kg), the drug was rapidly absorbed with peak serum concentration of 3.32 +/- 0.59 micrograms/ml at 20-30 min; the absorption half-life was 3.9 +/- 0.9 min. The systemic availability of tobramycin was 90.7 +/- 14.4%. The apparent half-life was 201 +/- 40 min, which was not significantly longer than the half-life following i.v. administration of the drug. Based on the pharmacokinetic values obtained in this study, a dosing rate of 2.5 mg/kg administered by i.m. injection at 12-h intervals can be recommended. This dosage regimen should achieve an average steady state serum concentration of 4 micrograms/ml with peak serum concentration approaching, but not exceeding, 10 micrograms/ml.

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Effect of Antibiotic Class and Concentration on the Release of Lipopolysaccharide from Escherichia coli

Evans

Pollack

1993

Journal of Infectious Diseases

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The ability of six antibiotics from different classes to release radiolabeled lipopolysaccharide (LPS) from a phenotypically smooth galE mutant of Escherichia coli O111:B4 was examined. Antibiotic concentrations were 0.0625-512 micrograms/mL. LPS release increased as a function of the antibiotic concentration, reaching a limit at or near the concentration that killed the majority of bacteria. The maximum amount of LPS released by polymyxin B was 40.6% +/- 0.9%, by gentamicin 58.2% +/- 2.5%, by ciprofloxacin 65.8% +/- 2.5%, by ceftazidime 73.1% +/- 0.9%, by tetracycline 75.3% +/- 10.0%, and by imipenem 79.7% +/- 2.3%. In timed experiments, ceftazidime released 61.9% +/- 1.2%, imipenem 51.1% +/- 8.8%, and tetracycline 39.7% +/- 4.4% of the LPS within the first hour of incubation, whereas polymyxin B released 13.5% +/- 1.9%, gentamicin 9.8% +/- 3.6%, and ciprofloxacin 12.7% +/- 2.6% of the LPS (P < .05). Fluoro-radiography and immunoblot analyses revealed similar migration patterns for antibiotic-released and cell-bound LPS on SDS-PAGE gels, suggesting similar O-polysaccharide content in the two LPS fractions. The amount and rate of LPS release from an E. coli strain was dependent upon antibiotic class and concentration.

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Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

Cited by 3 publications

References 0 publications

Comparative pharmacokinetics of aminoglycoside antibiotics

Comparative pharmacokinetics of aminoglycoside antibiotics

Pharmacokinetics of tobramycin in the camel

Effect of Antibiotic Class and Concentration on the Release of Lipopolysaccharide from Escherichia coli

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