Reproducibility of the Retinal Vascular Response to Flicker Light in Asians

Nguyên, Thành Tâm; Kreis, Andreas; Kawasaki, Ryo; Wang, Jie Jin; Seifert, Bernd-U; Vilser, Walthard; Nagel, Edgar; Wong, Tien Yin

doi:10.3109/02713680903353764

Cited by 23 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As parameters the maximum flicker dilation and the maximum constriction will be determined. Flicker-evoked dilation of retinal arterioles measured by the DVA has proven to be a parameter that is suitable as a functional parameter of the regulation ability of retinal arteries [6, 7]. …”

Section: Materials and Methodologymentioning

confidence: 99%

“…have demonstrated the high reproducibility of DVA for repeated measures over a short period of time in a study group of 33 healthy subjects. The authors reached the conclusion that such measurements may allow non-invasive quantification of endothelial function to study its association with systemic and ocular diseases [7]. A general overview of the use of DVA in research and in a clinical setting and informed guidelines for its use have recently been given by Garhofer et al [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Laser Cyclophotocoagulation Enhances the Regulative Capacity of Retinal Vessels in Glaucoma

Anastassiou¹,

Schallenberg²,

Steuhl³

et al. 2014

TOOPHTJ

View full text Add to dashboard Cite

Purpose: To determine the effects of laser surgical IOP reduction by means of transscleral cyclophotocoagulation (CPC) on retinal blood flow parameters in glaucoma patients using Dynamic Vessel Analysis (DVA). Materials and Methodology: 26 patients (average age: 70 years) with a long history of primary open angle glaucoma underwent CPC. The effect on the reactive capacity of retinal vessels was assessed before and 6-8 weeks after CPC by means of the Dynamic Vessel Analyzer (DVA) using flicker light provocation. Results: In our group of POAG patients, IOP was significantly reduced about approximately 20% by CPC while systemic blood pressure and heart rate were not changed. The most obvious differences between the pre- and postoperative DVA measurements could be observed in the maximal dilation of the retinal arteries which increased from 0.75 % (+/- 0.6) to 3.17 % (+/- 0.5) with an average increase of 2.4 % (p<0.01). In addition, the ability of the arteries for constriction improved significantly (p<0.05) while the dynamic responses of the veins and the initial baseline values (MU) of the vessel diameters did not change. Conclusions: Our results of DVA measurements after an IOP-lowering laser surgical intervention (CPC) reveal a significant recovery of the regulative capacity of retinal arteries in glaucoma patients that has up to now neither been properly documented nor appreciated. Future studies with long-term follow-up must determine the clinical importance of these findings for the treatment of glaucoma patients.

show abstract

Section: Materials and Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laser Cyclophotocoagulation Enhances the Regulative Capacity of Retinal Vessels in Glaucoma

Anastassiou¹,

Schallenberg²,

Steuhl³

et al. 2014

TOOPHTJ

View full text Add to dashboard Cite

show abstract

“…Nguyen et al have demonstrated the high reproducibility of DVA for repeated measures over a short period of time on a study group of 33 healthy subjects. The authors reached the conclusion that such measurements may allow non-invasive quantification of endothelial function to study its association with systemic and ocular diseases [14].…”

Section: Methodsmentioning

confidence: 99%

Correlation of Retinal Vessel Analysis and Nerve Fiber Layer Thickness in Normal Tension Glaucoma

Schallenberg¹

2015

J Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…We chose skin and retina for 2 reasons. First, these sites are easily accessible, enabling direct and reproducible assessment of microvascular (endothelial) function, as measured by heat‐induced skin hyperemia and flicker light‐induced retinal arteriolar dilation. Second, skin and retina may differ in their associations with physical activity and sedentary behavior, with skin potentially showing stronger associations.…”

Section: Introductionmentioning

confidence: 99%

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes—The Maastricht Study

et al. 2020

View full text Add to dashboard Cite

Objective Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function. Methods In The Maastricht Study, a population‐based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer‐assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes. Results In individuals with type 2 diabetes, total physical activity and higher‐intensity physical activity were independently associated with greater heat‐induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher‐intensity physical activity were not associated with heat‐induced skin hyperemia. No associations with retinal arteriolar %‐dilation were identified. Conclusion Higher levels of total and higher‐intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

show abstract

Reproducibility of the Retinal Vascular Response to Flicker Light in Asians

Cited by 23 publications

References 20 publications

Laser Cyclophotocoagulation Enhances the Regulative Capacity of Retinal Vessels in Glaucoma

Laser Cyclophotocoagulation Enhances the Regulative Capacity of Retinal Vessels in Glaucoma

Correlation of Retinal Vessel Analysis and Nerve Fiber Layer Thickness in Normal Tension Glaucoma

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes—The Maastricht Study

Contact Info

Product

Resources

About