Reproducibility of the Laser Flare Meter and Laser Cell Counter in Assessing Anterior Chamber Inflammation Following Cataract Surgery

El-Harazi, Shérif M.; Feldman, Robert M.; Chuang, Alice Z.; Ruiz, Richard; Villanueva, Guillermina

doi:10.3928/1542-8877-19980501-05

Cited by 28 publications

(9 citation statements)

References 7 publications

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“…A reliable reproducibility of in-vivo tyndallometric measurements has been demonstrated in various studies. [6][7][8] So far, there is only little data on the tyndall effect in eyes with retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

Association between blood-aqueous barrier disruption and extent of retinal detachment

Schoeneberger

Eberhardt

Menghesha

et al. 2022

European Journal of Ophthalmology

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Purpose To investigate the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder measured by non-invasiv laser flare photometry. Methods Retrospective evaluation of consecutive patients with RRD that underwent surgery between November 2016 and October 2018. Descriptive evaluation of pre- and postoperative parameters and correlation to preoperative laser flare value, extent of retinal detachment and re-detachment rate were performed. Results 266 patients (mean age 62.73 ± 10.40 years, 62.8% male) were included. Mean preoperative flare value was 11.0 ± 11.9 pc/ms. In pseudophakia flare values were higher than in phakia (12.7 ± 10.4 pc/ms versus 9.8 ± 12.9 pc/ms; p = 0.042). Flare increased and correlated significantly with the number of affected retinal quadrants (Q) (1 Q 6.4 ± 3.3 pc/ms; 2 Q 10.5 ± 8.8 pc/ms; 3 Q 15.6 ± 9.1 pc/ms; 4 Q 27.5 ± 33.3 pc/ms; p < 0.001; r = 0.40). Macular status correlated significantly with flare values (macula on 8.6 ± 7.1 pc/ms, off 13.1 ± 15.0 pc/ms; p = 0.004; r = 0.17). Conclusion The level of objective tyndallometry in RRD seems to be influenced by lens status and extent of retinal detachment. Thus, the greater the affected retinal area is, the more blood-aqueous barrier disruption seems to be present.

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Section: Discussionmentioning

confidence: 99%

Association between blood-aqueous barrier disruption and extent of retinal detachment

Schoeneberger

Eberhardt

Menghesha

et al. 2022

European Journal of Ophthalmology

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“…The magnitude of aqueous flare is a predictor of the severity of uveitis 11 and intraocular inflammation following cataract surgery. 12–16 An increase in aqueous flare in response to prostaglandins has also been reported in rabbits, 17–19 although not in humans. The aqueous flare is also elevated during diabetes, 20,21 retinal detachment, 22–25 and retinitis pigmentosa.…”

Section: Discussionmentioning

confidence: 94%

Ocular Spot Fluorometer Equipped With a Lock-In Amplifier for Measurement of Aqueous Flare

Sudhir

Murthy

Tadepalli

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeTo evaluate a custom-made ocular fluorometer for detection of intensity of light scatter (ILS) from the anterior chamber (A/C) as an objective measure of aqueous flare.MethodsThe fluorometer, equipped with a lock-in amplifier, was employed in the scatter mode to detect ILS from A/C. Measurements were performed with two illumination slit widths of 0.5 and 0.25 mm. The axial resolution at these slit widths were 80 and 200 μm, respectively. Healthy and pseudophakic eyes, with grade 0 Standardization of Uveitis Nomenclature (SUN) score, were employed as control subjects. ILS was also recorded in a cohort of patients who had undergone phacoemulsification and showed grades 1+ or 2+ on postoperative days 1 and 4.ResultsThe inter- and intraobserver variabilities in the measurement of ILS were not significant. In cataract patients, ILS was significantly higher on postoperative day 1 relative to healthy eyes. By day 4, ILS decreased significantly and was only marginally different from ILS in quiet pseudophakic eyes or healthy eyes. Eyes with higher SUN scores showed proportionately increased ILS. The receiver-operator characteristic analysis indicated no advantage in using the smaller slit width in discriminating ILS at different SUN scores although it provided higher axial resolution.ConclusionsThe lock-in–based spot fluorometer is reliable for measurement of ILS with high precision and accuracy.The measured ILS correlates linearly with SUN scores and can be used to provide a higher granularity for recording aqueous flare.Translational RelevanceThe instrument can be used in the clinical management of uveitis and drug development toward uveitis.

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“…The results showed that the measurements are highly reproducible with low intra-and interobserver variations. [ 8 9 ]…”

Section: Alidation Of Flare Measurementmentioning

confidence: 99%

Laser flare photometry in uveitis

2022

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Reproducibility of the Laser Flare Meter and Laser Cell Counter in Assessing Anterior Chamber Inflammation Following Cataract Surgery

Cited by 28 publications

References 7 publications

Association between blood-aqueous barrier disruption and extent of retinal detachment

Association between blood-aqueous barrier disruption and extent of retinal detachment

Ocular Spot Fluorometer Equipped With a Lock-In Amplifier for Measurement of Aqueous Flare

Laser flare photometry in uveitis

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