Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

Yörükoğlu, Kutsal; Tuna, Burçin; Dikicioğlu, Emel; Düzcan, Ender; İşisağ, Aydın; Şen, Sait; Mungan, Uğur; Kirkali, Ziya

doi:10.1007/s00428-003-0905-0

Cited by 59 publications

(41 citation statements)

References 36 publications

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“…However, other reports demonstrated a significant relationship between tumor grade and patient survival [1] . These contradictory results might be due to the presence of inter-and intra-individual variations in evaluation of tumor grades in patients with bladder tumors [7,28] . On the other hand, Ghoneim et al [1] studied a large cohort of patients (1026 patients; 764 men and 262 women) with different types of bladder cancer (Squamous, transitional carcinoma, and adenocarcinoma), with very long follow up times (up to 24 years) and relative higher incidences of regional lymph nodes metastasis (18.3%).…”

Section: Discussionmentioning

confidence: 96%

Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer

El-Chennawi

Auf²,

Metwally³

et al. 2009

WJGO

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AIM:To evaluate the relationship between vascular endothelial growth factor (VEGF), p53 , and the H-ras oncogene and different clinicopathological parameters in Egyptian patients with Schistosoma-associated transitional cell carcinoma of the bladder. METHODS:The study included 50 patients with transitional cell carcinoma for whom radical cystectomy and urinary diversions were carried out. VEGF and p53 protein expressions were evaluated with an immunohistochemical staining method, and H-ras oncogene mutations were analyzed with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. RESULTS:High grade tumors revealed higher p53 immunostaining than low grade tumors (P = 0.016).p53 and VEGF protein expressions, as well as H-ras oncogene mutations, had an insignificant impact on patient outcomes (P = 0.962, P = 0.791, and P = 967, respectively). Cancer extension to regional lymph nodes was associated with poor outcomes (P = 0.008). CONCLUSION:

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Section: Discussionmentioning

confidence: 96%

Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer

El-Chennawi

Auf²,

Metwally³

et al. 2009

WJGO

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“…In a recent study published by May, the agreement on grade among four pathologists was 38-73% when using the 1973 WHO classification and 72-83% when using the 2004 WHO/ ISUP classification [36]. Analogous values in previously published studies were in the ranges of 17-80% and 33-95%, respectively [30,[37][38][39][40][41][42][43][44][45]. These data are presented in Table V.…”

Section: Gradingmentioning

confidence: 53%

Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Poletajew¹,

Fus²,

Pomada³

et al. 2014

pjp

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Staging and grading of bladder cancer have a substantial impact on patients' prognosis. However, due to the relatively low quality and quantity of specimens from transurethral resection (TUR), initial histopathological examination may not be fully reliable. The aim of this study was to assess the repeatability of staging and grading in post-TUR and post-radical cystectomy (RC) specimens. Staging and grading in TUR and RC specimens were compared in a group of 181 consecutive patients. All microscopic examinations were performed by dedicated uropathologists. Median time from TUR to RC was 45 days. Additionally, an attempt to identify potential clinical variables influencing the risk of discrepancies was made. In post-RC specimens, the disease was down-staged in 13.8% and up-staged in 54.6% of patients (K = -0.03, p < 0.02). Muscle-invasive bladder cancer was diagnosed in 67.6% of patients initially staged as T1. Cancer was down-graded in 10.3% and up-graded in 17.9% of patients (K = 0.44, p < 0.02). Early onset of disease, female sex and time interval from transurethral resection of bladder tumor (TURBT) to RC had no effect on incidence of discrepancies. Pathological post-TUR examination is not predictive for the final stage of cancer. The incidence of under-or overgrading of bladder cancer is significant, and efforts should be made to reduce it.

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“…Gönül et al 12 Les données de la littérature quant à la reproductibilité intra-observateur des deux classifications sont très controversées avec des valeurs de kappa variant de 0,45 à 0,89 16 . Dans notre étude, la reproductibilité était excellente pour les deux classifications.…”

Section: Discussionunclassified

Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie

Abdelkrim

Rammeh

Trabelsi

et al. 2012

CUAJ

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E230Cite as: Can Urol Assoc J 2012;6:E230-E233. http://dx.doi.org/10.5489/cuaj.10078. Epub 2011 Sept 8. Résumé Methods:One hundred and two cases of pTa/pT1 papillary urothelial bladder tumours were evaluated retrospectively. Two pathologists reviewed the slides and assigned a tumour grade according to the 1973 and the 2004 WHO classifications. Whenever a discrepancy was noted between the first and the second reading, the two pathologists together reviewed the slides and reached a consensus for the final grading according to the two classifications. Intraobserver variability was assessed by one of the two pathologists who reviewed the slides one month later. Interpretive discrepancies for each category of neoplasm were documented. Degree of agreement and reproducibility were evaluated using intra-and inter-rater techniques (kappa statistic). A value of 0.21-0.40 was accepted as weak, 0.41-0.60 as moderate, 0.61-0.80 as substantial and 0.81-1 as absolute agreement. Results: According to the 1973 WHO classification, the proportions of G1, G2 and G3 tumours were 40.2%, 50% and 9.8%, respectively. According to the 2004 WHO classification, the proportions of tumours of low malignant potential, low-grade carcinomas, and high-grade carcinomas were 23.5%, 60.8% and 15.7%, respectively. The intra-observer reproducibility was excellent for the two classifications (absolute agreement). The degree of agreement between pathologists was higher in the 2004 WHO (kappa = 0.7) than the 1973 WHO classification (kappa = 0.51). Conclusions:The present findings suggest that the new proposed classification system for urothelial papillary neoplasms slightly increases the inter-observer reproducibility. The intra-observer reproducibility is excellent for the two classifications.

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Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

Abstract: The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.

Cited by 59 publications

References 36 publications

Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer

Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer

Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Reproductibilité des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie

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