Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis

Wilkinson, Ian B.; Fuchs, Sabine A.; Jansen, I.; Spratt, James C.; Murray, Gordon D.; Cockcroft, John R.; Webb, David J.

doi:10.1097/00004872-199816121-00033

Cited by 861 publications

(720 citation statements)

References 14 publications

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“…The correlation between invasive and non-invasive techniques was high for the estimation of central SBP (r ¼ 0.99, Po0.001). 56 As long as reproducibility is regarded, our estimation for the intra-observer difference for the measurement of AI was 1.75 ± 4.6%, which is close to the difference reported in a previous study (0.49 ± 5.37), 21 showing that the method has very good reproducibility.…”

Section: Lydakis Et Alsupporting

confidence: 88%

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Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise

et al. 2008

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Chronic dynamic (aerobic) exercise decreases central arterial stiffness, whereas chronic resistance exercise evokes the opposite effect. Nevertheless, there is little information available on the effects of acute bouts of exercise. Also, there is limited data showing an increase of central arterial stiffness during acute mental stress. This study aimed to determine the effect of acute mental and physical (static and dynamic exercise) stress on indices of central arterial stiffness. Fifteen young healthy volunteers were studied. The following paradigms were performed: (1) 2 min of mental arithmetic, (2) short bouts (20 s) of static handgrip at 20 and 70% of maximal voluntary contraction (MVC), (3) fatiguing handgrip at 40% MVC and (4) incremental dynamic knee extensor exercise. Central aortic waveforms were assessed using SphygmoCor software. As compared to baseline, pulse wave transit time decreased significantly for all four interventions indicating that central arterial stiffness increased. During fatiguing handgrip there was a fall in the ratio of peripheral to central pulse pressure from 1.69 ± 0.02 at baseline to 1.56±0.05 (Po0.05). In the knee extensor protocol a nonsignificant trend for the opposite effect was noted. The augmentation index increased significantly during the arithmetic, short static and fatiguing handgrip protocols, whereas there was no change in the knee extensor protocol. We conclude that (1) during all types of acute stress tested in this study (including dynamic exercise) estimated central stiffness increased, (2) during static exercise the workload posed on the left ventricle (expressed as change in central pulse pressure) is relatively higher than that posed during dynamic exercise (given the same pulse pressure change in the periphery).

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Section: Lydakis Et Alsupporting

confidence: 88%

“…Pulse wave analysis has previously been described as a simple and reproducible non-invasive method for assessing augmentation index (AI). 21 In brief, a high-fidelity micromanometer (SPC-301) was used to flatten but not occlude the radial artery, using gentle pressure. The radial waveform was recorded on a portable computer.…”

Section: Pulse Wave Analysismentioning

confidence: 99%

Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise

et al. 2008

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“…7,10 The PWV measurement was also shown to have good reproducibility. 12 Venous blood samples were drawn in fasting state, and frozen serum samples stored at -80 degrees were used for biochemical laboratory analyses in the series. 25 …”

Section: Examinations and Materialsmentioning

confidence: 99%

The association between low 25-hydroxyvitamin D and increased aortic stiffness

et al. 2011

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There is accumulating evidence that vitamin D exerts important pathophysiological effects on cardiovascular system. Low vitamin D was associated with increased cardiovascular risk in several reports. We studied the association between vitamin D and arterial stiffness in a random sample of 560 subjects selected from general population. Arterial stiffness was measured as aortic pulse-wave velocity (PWV) using Sphygmocor device. Serum 25-hydroxyvitamin D (25(OH)D) was measured using commercial kits. We found a clear negative trend in aortic PWV among 25(OH)D quartiles. Subjects in the bottom 25(OH)D quartile (o20 ng ml À1 ) showed the highest aortic PWV (9.04 m s À1 ), compared with 2nd-4th quartile (8.07 m s À1 , 7.93 m s À1 and 7.70 m s À1 , respectively; P for trend o0.0001). The association between 25(OH)D and aortic PWV remained significant after adjustment for age, gender and other potential confounders; subjects in the first 25(OH)D quartile had adjusted odds ratio 2.04 (1.26-3.30) for having aortic PWV X9 m s À1 (top quartile) in multiple regression. In conclusion, we found a clear significant and independent negative association between 25(OH)D and aortic PWV. Subjects with lowest vitamin D status showed the highest arterial stiffness.

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“…18 Moreover, by gating measurements to the R wave of an ECG, and making recordings at two sites, PWV can also be measured. We have already shown that the system can be used reproducibly in various patient groups, 24 and believe that it provides an ideal tool with which to assess arterial stiffness easily and rapidly in large outcome-based studies. 25 PWA may also improve our understanding of the physiological mechanisms regulating arterial stiffness and be a useful method with which to assess the effect of drugs on the arterial tree.…”

Section: Pulse Wave Analysismentioning

confidence: 99%