Reproducibility Of Positron Emission Tomography (PET)-Measured [18F]Fluorodeoxyglucose ([18F]FDG) Uptake As A Marker Of Lung Inflammation In Chronic Obstructive Pulmonary Disease (COPD)

Chen, Delphine L.; Azulay, David-Olivier; Atkinson, Jeffrey J.; Yusen, Roger J.; Brody, Steven L.; Kozlowski, James; Thomas, Betsy; McCarthy, Timothy J.; Danto, Spencer I.; Miller, J. Philip; Vennart, W.; Mintun, Mark A.; Schuster, Daniel P.

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6449

Cited by 3 publications

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“…Preliminary results from our own institution, from a protocol approved by our Institutional Review Board and with written consent from participants, further suggest that patients with chronic bronchitis symptomatology have increased 18 F-FDG uptake compared with those without such symptoms ( Fig. 2; data published in abstract form from Chen et al (52)), in line with the known increased lung inflammation that occurs with chronic bronchitis (55). Together, the available data suggest that 18 F-FDG uptake may be useful in distinguishing inflammatory phenotypes within COPD.…”

Section: Disease-specific Investigations Copd and Asthmamentioning

confidence: 87%

Imaging Pulmonary Inflammation

Scherer

Chen

2016

J Nucl Med

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Section: Disease-specific Investigations Copd and Asthmamentioning

confidence: 87%

Imaging Pulmonary Inflammation

Scherer

Chen

2016

J Nucl Med

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“…The reproducibility of this method was highlighted by Chen et al in abstract form; they compared 10 COPD patients to healthy age matched controls and scanned each object 3 times during a 7 weeks period. They found significantly higher FDG uptake in COPD patients compared to controls irrespective of the examination time point (100).…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 93%

Potential Applications of PET Scans, CT Scans, and MR Imaging in Inflammatory Diseases

et al. 2020

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Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

et al. 2017

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BackgroundAn inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising 18F-FDG PET scans from COPD subjects with elevated circulating inflammatory markers (fibrinogen) and matched healthy volunteers (HV). Dynamic 18F-FDG PET scans were obtained for high-fibrinogen (>2.8 g/l) COPD subjects (N = 10) and never smoking HV (N = 10). Lungs were segmented using co-registered computed tomography images and subregions (upper, middle and lower) were semi-automatically defined. A quantitative analysis approach was developed, which corrects for the presence of air and blood in the lung (qABL method), enabling direct estimation of the metabolic rate of FDG in lung tissue. A normalised Patlak analysis approach was also performed to enable comparison with previously published results. Effect sizes (Hedge’s g) were used to compare HV and COPD groups.ResultsThe qABL method detected no difference (Hedge’s g = 0.15 [−0.76 1.04]) in the tissue metabolic rate of FDG in the whole lung between HV (μ = 6.0 ± 1.9 × 10−3 ml cm−3 min−1) and COPD (μ = 5.7 ± 1.7 × 10−3 ml cm−3 min−1). However, analysis with the normalised Patlak approach detected a significant difference (Hedge’s g = −1.59 [−2.57 −0.48]) in whole lung between HV (μ = 2.9 ± 0.5 × 10−3 ml cm−3 min−1) and COPD (μ = 3.9 ± 0.7 × 10−3 ml cm−3 min−1). The normalised Patlak endpoint was shown to be a composite measure influenced by air volume, blood volume and actual uptake of 18F-FDG in lung tissue.ConclusionsWe have introduced a quantitative analysis method that provides a direct estimate of the metabolic rate of FDG in lung tissue. This work provides further understanding of the underlying origin of the 18F-FDG signal in the lung in disease groups and helps interpreting changes following standard or novel therapies.Electronic supplementary materialThe online version of this article (doi:10.1186/s13550-017-0291-2) contains supplementary material, which is available to authorized users.

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Reproducibility Of Positron Emission Tomography (PET)-Measured [18F]Fluorodeoxyglucose ([18F]FDG) Uptake As A Marker Of Lung Inflammation In Chronic Obstructive Pulmonary Disease (COPD)

Cited by 3 publications

References 0 publications

Imaging Pulmonary Inflammation

Imaging Pulmonary Inflammation

Potential Applications of PET Scans, CT Scans, and MR Imaging in Inflammatory Diseases

Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

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