Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

Mashhood, Arian; Railkar, Radha; Yokoo, Takeshi; Levin, Yakir S.; Clark, Lisa; Fox-Bosetti, Sabrina; Middleton, Michael S.; Riek, Jonathan K.; Kauh, Eunkyung; Dardzinski, Bernard J.; Williams, Donald S.; Sirlin, Claude B.; Shire, Norah J.

doi:10.1002/jmri.23928

Cited by 68 publications

(66 citation statements)

References 50 publications

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“…The lack of significant difference in the splenic FF supports the notion that slice thickness likely did not contribute to the effect seen for renal FF. Though not directly confirmed in this study, the difference in scanner models also is not expected to impact proton-density FF estimates based on previous multi-vendor, multi-platform reproducibility studies of hepatic steatosis (38,39). Lastly, the observed effect size (i.e.…”

Section: Discussionmentioning

confidence: 49%

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Yokoo

Clark

Pedrosa

et al. 2016

Magnetic Resonance Imaging

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Purpose To evaluate renal lipid content in subjects with and without type II diabetes mellitus (DM2) using Dixon-based magnetic resonance imaging (MRI). Materials and Methods This retrospective study was approved by institutional review board and compliant with Health Insurance Portability and Accountability Act. Sixty-nine adults with or without DM2 (n=29, n=40) underwent 3T MRI of the abdomen using 3D multiecho Dixon gradient-echo acquisition and proton-density fat fraction (FF) reconstruction. FF values were recorded within segmented regions of interest in the kidneys and liver. The FF measurement error was estimated from the within-subject difference between the right and left kidneys using Bland-Altman Analysis. Correlation between renal FF, hepatic FF, and body mass index (BMI) was evaluated. The association between renal FF and DM2 was evaluated by Wilcoxon rank sum test as well as by multivariate regression to correct for potential confounding effects of age, sex, BMI, creatinine, and hepatic FF. P-values <0.05 were considered statistically significant. Results Per-subject 95% limit of agreement of the renal FF measurement was [−3.26%, +3.22%]. BMI was significantly correlated to renal FF (r=0.266, p=0.027) and to liver FF (r=0.344, p=0.006). Correlation between renal and hepatic FF did not reach statistical significance (r=0.215, p=0.090). Median renal FF (±interquartile range) was 2.18% (±2.52%) in the DM2 cohort, significantly higher than 0.80% (±2.63%) in the non-DM2 cohort (p<0.001). After correcting for potential confounders, the relationship between DM2 and renal FF remained statistically significant (p=0.005). Conclusion Renal lipid content can be measured noninvasively using Dixon-based MRI and may be increased in subjects with DM2 compared to those without DM2.

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Section: Discussionmentioning

confidence: 49%

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Yokoo

Clark

Pedrosa

et al. 2016

Magnetic Resonance Imaging

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“…Third, our study was a single-center study and all our cases were scanned with a 3T scanner. However, recent studies have shown that M-MRI-PDFF is reproducible across MR scanners from different manufacturers and at different field strengths (32, 37), so our results are likely to be generalizable to other scanners and field strengths. Fourth, we did not assess C-MRI methods.…”

Section: Discussionmentioning

confidence: 58%

Accuracy of multiecho magnitude‐based MRI (M‐MRI) for estimation of hepatic proton density fat fraction (PDFF) in children

Zand

Shah

Heba

et al. 2015

Magnetic Resonance Imaging

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Purpose To assess accuracy of magnitude-based magnetic resonance imaging (M-MRI) in children to estimate hepatic proton density fat fraction (PDFF) using two to six echoes, with magnetic resonance spectroscopy (MRS)-measured PDFF as a reference standard. Materials and Methods This was an IRB-approved, HIPAA-compliant, single-center, cross-sectional, retrospective analysis of data collected prospectively between 2008 and 2013 in children with known or suspected non-alcoholic fatty liver disease (NAFLD). Two hundred and eighty-six children (8 – 20 [mean 14.2 ± 2.5] yrs; 182 boys) underwent same-day MRS and M-MRI. Unenhanced two-dimensional axial spoiled gradient-recalled-echo images at six echo times were obtained at 3T after a single low-flip-angle (10°) excitation with ≥ 120-ms recovery time. Hepatic PDFF was estimated using the first two, three, four, five, and all six echoes. For each number of echoes, accuracy of M-MRI to estimate PDFF was assessed by linear regression with MRS-PDFF as reference standard. Accuracy metrics were regression intercept, slope, average bias, and R2. Results MRS-PDFF ranged from 0.2 – 40.4% (mean 13.1 ± 9.8%). Using three to six echoes, regression intercept, slope, and average bias were 0.46 – 0.96%, 0.99 – 1.01, and 0.57 – 0.89%, respectively. Using two echoes, these values were 2.98%, 0.97, and 2.72%, respectively. R2 ranged 0.98 – 0.99 for all methods. Conclusion Using three to six echoes, M-MRI has high accuracy for hepatic PDFF estimation in children.

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“…Pharmacodynamic and clinical effects were assessed by measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, TGs, low-density lipoprotein [LDL], high-density lipoprotein [HDL], alkaline phosphatase, gamma-glutamyl transferase (GGT), C-reactive protein and ferritin. Liver volume was assessed by MRI and hepatic proton density fat fraction (PDFF), a measure of lipid content, was assessed by MRI (multi-echo gradient-echo sequence imaging) or 1 H-MRS (if available)[18–21]. …”

Section: Methodsmentioning

confidence: 99%

Sebelipase alfa over 52weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency

Valayannopoulos

Malinová

Honzík

et al. 2014

Journal of Hepatology

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Background and aims Lysosomal Acid Lipase Deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. Methods Sebelipase alfa (1 mg/kg or 3 mg/kg) was infused every-other-week to eligible subjects. Safety and tolerability assessments, including liver function, lipid profiles and liver volume assessment, were carried out at regular intervals. Results 216 infusions were administered to eight adult subjects through Week 52 during LAL-CL04. At Week 52, mean alanine aminotransferase and aspartate aminotransferase were normal with mean change from baseline of −58% and −40%. Mean change for low density lipoprotein, total cholesterol, triglyceride and high-density lipoprotein were −60%, −39%, −36%, and +29%, respectively. Mean liver volume by magnetic resonance imaging and hepatic proton density fat fraction decreased (12% and 55%, respectively). Adverse events were mainly mild and unrelated to sebelipase alfa. Infusion-related reactions were uncommon: three events of moderate severity were reported in two subjects; one patient's event was suggestive of hypersensitivity-like reaction, but additional testing did not confirm this, and the subject has successfully re-started sebelipase alfa. Of samples tested to date, no anti-drug antibodies have been detected. Conclusions Long-term dosing with sebelipase alfa in Lysosomal Acid Lipase-Deficient patients is well tolerated and produces sustained reductions in transaminases, improvements in serum lipid profile and reduction in hepatic fat fraction. A randomized, placebo-controlled phase 3 trial in children and adults is underway (ARISE: NCT01757184).

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Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

Abstract: Methods 2 and 3 accurately assess FF. Strong reproducibility across magnet type and strength render them suitable for use in multicenter trials and longitudinal assessments.

Cited by 68 publications

References 50 publications

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Accuracy of multiecho magnitude‐based MRI (M‐MRI) for estimation of hepatic proton density fat fraction (PDFF) in children

Sebelipase alfa over 52weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency

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