Reproducibility of Heel Ultrasound Measurement in Prepubescent Children

Brooks, Evelyn; High, M. Dean; Duty, Eileen; Bronson, Wendell

doi:10.7863/jum.2003.22.12.1337

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…In previous studies conducted on children, coefficient of variation was 1.9–3.5% [17]–[19]. Good values of short- and long-term interunit precision were reported in a prospective multicenter study [20], [21].…”

Section: Methodsmentioning

confidence: 73%

“…Measuring SI with QUS has value in assessing associations in children. In fact, over the last decades, many studies used QUS to study bone strength in healthy children at the calcaneus [17]–[19], [32], [33] even in preschool children [12], [34] and it was suggested to predict the risk of osteopenia or fragility fracture [33], [35]. Calcaneus is the most popular site for QUS measurement since it consists for 90% of trabecular bone and has a high turnover rate and therefore will show bone metabolic changes first [1].…”

Section: Discussionmentioning

confidence: 99%

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Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children

et al. 2013

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Neuromedin U, encoded by the NMU gene, is a hypothalamic neuropeptide that regulates both energy metabolism and bone mass. The beta-2 adrenergic receptor, encoded by the ADRB2 gene, mediates several effects of catecholamine hormones and neurotransmitters in bone. We investigated whether NMU single nucleotide polymorphisms (SNPs) and haplotypes, as well as functional ADRB2 SNPs, are associated with bone stiffness in children from the IDEFICS cohort, also evaluating whether NMU and ADRB2 interact to affect this trait. A sample of 2,274 subjects (52.5% boys, age 6.2±1.8 years) from eight European countries, having data on calcaneus bone stiffness index (SI, mean of both feet) and genotyping (NMU gene: rs6827359, rs12500837, rs9999653; ADRB2 gene: rs1042713, rs1042714), was studied. After false discovery rate adjustment, SI was significantly associated with all NMU SNPs. rs6827359 CC homozygotes showed the strongest association (recessive model, Δ = −1.8, p = 0.006). Among the five retrieved haplotypes with frequencies higher than 1% (range 2.0–43.9%), the CCT haplotype (frequency = 39.7%) was associated with lower SI values (dominant model, Δ = −1.0, p = 0.04) as compared to the most prevalent haplotype. A non-significant decrease in SI was observed in in ADRB2 rs1042713 GG homozygotes, while subjects carrying SI-lowering genotypes at both SNPs (frequency = 8.4%) showed much lower SI than non-carriers (Δ = −3.9, p<0.0001; p for interaction = 0.025). The association was more evident in preschool girls, in whom SI showed a curvilinear trend across ages. In subgroup analyses, rs9999653 CC NMU or both GG ADRB2 genotypes were associated with either lower serum calcium or β-CrossLaps levels (p = 0.01). This study in European children shows, for the first time in humans, a role for NMU gene through interaction with ADRB2 gene in bone strength regulation, more evident in preschool girls.

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Section: Methodsmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children

et al. 2013

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Physical Examinations

Bammann¹,

Peplies²,

Mårild³

et al. 2018

Instruments for Health Surveys in Children and Adolescents

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Relationship Between Markers of Body Fat and Calcaneal Bone Stiffness Differs Between Preschool and Primary School Children: Results from the IDEFICS Baseline Survey

et al. 2012

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The aim of this study was to investigate the relationship between markers of body fat and bone status assessed as calcaneal bone stiffness in a large sample of European healthy pre- and primary school children. Participants were 7,447 children from the IDEFICS study (spread over eight different European countries), age 6.1 ± 1.8 years (range 2.1-9.9), 50.5 % boys. Anthropometric measurements (weight, height, bioelectrical impedance, waist and hip circumference, and tricipital and subscapular skinfold thickness) as well as quantitative ultrasonographic measurements to determine calcaneal stiffness index (SI) were performed. Partial correlation analysis, linear regression analysis, and ANCOVA were stratified by sex and age group: preschool boys (n = 1,699) and girls (n = 1,599) and primary school boys (n = 2,062) and girls (n = 2,087). In the overall study population, the average calcaneal SI was equal to 80.2 ± 14.0, ranging 42.4-153. The results showed that preschool children with higher body fat had lower calcaneal SI (significant correlation coefficients between -0.05 and -0.20), while primary school children with higher body fat had higher calcaneal SI (significant correlation coefficients between 0.05 and 0.13). After adjusting for fat-free mass, both preschool and primary school children showed an inverse relationship between body fat and calcaneal stiffness. To conclude, body fat is negatively associated with calcaneal bone stiffness in children after adjustment for fat-free mass. Fat-free mass may confound the association in primary school children but not in preschool children. Muscle mass may therefore be an important determinant of bone stiffness.

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Reproducibility of Heel Ultrasound Measurement in Prepubescent Children

Abstract: These data support the reliability and usefulness of ultrasound for assessment of pediatric bone status.

Cited by 5 publications

References 14 publications

Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children

Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children

Physical Examinations

Relationship Between Markers of Body Fat and Calcaneal Bone Stiffness Differs Between Preschool and Primary School Children: Results from the IDEFICS Baseline Survey

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