Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopy

Lymer, Katherine; Haga, Kristin; Marshall, Ian; Sailasuta, Napapon; Wardlaw, Joanna M.

doi:10.1016/j.mri.2006.10.010

Cited by 17 publications

(15 citation statements)

References 32 publications

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“…The 2HG specific J-coupling pattern is suitable for selectively detecting the resonance of interest using several J-resolved spectroscopic editing detection methods currently available at clinical 3 T MRI systems [26] to overcome the signal overlap. These selective J-coupling-based resonance detection methods have been applied previously in detecting neurochemicals, such as γ-aminobutyric acid and lactate, whose resonances overlapped with others in the peak-crowd spectral regions, in normal controls [27, 28] or glioma patients [29]. …”

Section: Discussionmentioning

confidence: 99%

Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

et al. 2012

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Somatic mutations in isocitrate dehydrogenase (IDH)1 and 2 have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specimens and used as a reliable biomarker to identify this subset of tumors. Specifically, we developed a two-dimensional correlation spectroscopy resonance method to reveal the distinctive cross-peak pattern of 2HG in the complex metabolite nuclear MR spectra of brain tumor tissues. This study demonstrates the feasibility, specificity, and selectivity of using MR detection and quantification of 2HG for the diagnosis and classification of IDH1/2 mutation-positive brain tumors. It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic.

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Section: Discussionmentioning

confidence: 99%

Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

et al. 2012

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“…By taking the cross-section, only one peak remains for quantification, hence losing a large amount of information. Furthermore, the overlap with the predominant singlets can still be considerable, as in case of GABA with creatine at 3 ppm, leading to poor experimental reproducibility (28).…”

Section: Introductionmentioning

confidence: 99%

Improved two‐dimensional J‐resolved spectroscopy

et al. 2006

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Localised two-dimensional J-resolved spectroscopy (JPRESS) is optimised for the in vivo detection of J-coupled metabolites using magnetic resonance spectroscopy at 3 T. The acquisition of echo signals starts as early as possible (i.e. maximum-echo sampling). This sampling scheme increases sensitivity and decreases overlap of peak tails, hence alleviating baseline problems. Reconstruction issues are discussed and the sensitivity is compared analytically with that of 1D PRESS. The qualitative behaviour of eddy currents in JPRESS is outlined and a 2D eddy current correction procedure based on the 1D phase deconvolution method is proposed.

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“…The difficulty in measuring GABA in proton MRS stems from two major factors: its very low concentration in the brain (0.8-1.9 mM per Lymer et al) (34) and its close spectral position with the more dominant glutamate and glutamine resonances. This makes GABA detection challenging and only a handful of in vivo GABA studies exist in schizophrenia.…”

Section: Proton Mrs Studies Of Gabamentioning

confidence: 99%

“…Just recently, specialized MRS techniques have become available which allow more reliable quantification of GABA (e.g., MEGA-PRESS [39], two-dimensional J-resolved PRESS [34]). The first study to use MEGA-PRESS in patients with schizophrenia found reduced GABA in the basal ganglia of early-stage schizophrenic patients (40).…”

Section: Proton Mrs Studies Of Gabamentioning

confidence: 99%

MR spectroscopy in schizophrenia

Port

Agarwal

2011

Magnetic Resonance Imaging

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The purpose of this study is to review the MR spectroscopic literature regarding schizophrenia. However, as there are over 250 primary MRS articles and dozens of MRS review articles on the subject already, this study will take a different approach. First, the clinical features of schizophrenia will be described. The background neuroanatomy and biochemistry relevant to schizophrenia will be reviewed, as many readers of this journal are unlikely to be familiar with these fields. A current model of the abnormal neural circuitry in schizophrenia will be presented, and predictions extrapolated about relevant metabolite changes over time. Finally, the existing MRS literature will be reviewed in the context of our existing anatomical and chemical knowledge, and future MRS research directions will be elaborated. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.

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Reproducibility of GABA measurements using 2D J-resolved magnetic resonance spectroscopy

Cited by 17 publications

References 32 publications

Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

Improved two‐dimensional J‐resolved spectroscopy

MR spectroscopy in schizophrenia

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