Reproducibility of Functional Transcranial Doppler Sonography in Determining Hemispheric Language Lateralization

Knecht, Stefan; Deppe, Michael; Ringelstein, E. Bernd; Wirtz, Markus; Lohmann, Hubertus; Dräger, Birgit; Huber, Thomas; Henningsen, H.

doi:10.1161/01.str.29.6.1155

Cited by 112 publications

(103 citation statements)

References 35 publications

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“…These studies focused more on auditory stimulation, cognitive tasks, language, memory tests, and motor tasks (Klingelhöfer et al 1999,Stroobant andVingerhoets 2000). These studies were validated through direct comparison against the Wada test, which uses an anesthetic for lateral suspension of brain activity (Strauss et al 1985), and against fMRI establishing fTCD as a viable complementary tool for functional brain imaging (Binder et al 1996;Deppe et al 2000;Desmond et al 1995;Knecht et al 1998). Functional TCD has since been applied to the study of migraines (De Benedittis et al 1999;Backer et al 2001), stroke recovery (Bragoni et al 2000;Matteis et al 2003), Alzheimer's disease (Asil and Uzuner 2005), Parkinson's disease (Troisi et al 2002), Huntington's disease (Deckel and Cohen 2000) and schizophrenia (Sabri et al 2003;Feldmann et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Functional Tissue Pulsatility Imaging of the Brain During Visual Stimulation

Kucewicz

Dunmire

Leotta

et al. 2007

Ultrasound in Medicine & Biology

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Functional tissue pulsatility imaging (fTPI) is a new ultrasonic technique being developed to map brain function by measuring changes in tissue pulsatility due to changes in blood flow with neuronal activation. The technique is based in principle on plethysmography, an older, non-ultrasound technology for measuring expansion of a whole limb or body part due to perfusion. Perfused tissue expands by a fraction of a percent early in each cardiac cycle when arterial inflow exceeds venous outflow and relaxes later in the cardiac cycle when venous drainage dominates. Tissue pulsatility imaging (TPI) uses tissue Doppler signal processing methods to measure this pulsatile "plethysmographic" signal from hundreds or thousands of sample volumes in an ultrasound image plane. A feasibility study was conducted to determine if TPI could be used to detect regional brain activation during a visual contrast-reversing checkerboard block paradigm study. During a study, ultrasound data were collected transcranially from the occipital lobe as a subject viewed alternating blocks of a reversing checkerboard (stimulus condition) and a static, gray screen (control condition). Multivariate Analysis of Variance (MANOVA) was used to identify sample volumes with significantly different pulsatility waveforms during the control and stimulus blocks. In 7 out 14 studies, consistent regions of activation were detected from tissue around the major vessels perfusing the visual cortex.

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Section: Introductionmentioning

confidence: 99%

Functional Tissue Pulsatility Imaging of the Brain During Visual Stimulation

Kucewicz

Dunmire

Leotta

et al. 2007

Ultrasound in Medicine & Biology

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“…Studies with TCD have been cross-validated by functional MRI (Schmidt et al, 1999), and reproducibility assessed (Knecht et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Cerebral lateralization and general intelligence: Gender differences in a transcranial Doppler study

Njemanze¹

2005

Brain and Language

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The present study evaluated cerebral lateralization during RavenÕs progressive matrices (RPM) paradigm in female and male subjects. Bilateral simultaneous transcranial Doppler (TCD) ultrasound was used to measure mean blood flow velocities (MBFV) in the right and left middle cerebral arteries (MCAs) in 24 (15 females and 9 males) right-handed normal subjects. The female subjects used a left hemisphere strategy, while males used a right hemisphere strategy to successfully solve RPM tasks. This implies that general intelligence is associated with neural systems within one hemisphere that are accessible to a variety of cognitive processes.

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“…It is also of interest to note that even though the LI-V, depends on a number of variables that could have a wide range of values, it demonstrated an excellent repeatability in our study. Previously, Knecht et al (1998) reported good repeatability of a word production task in successive fTCD measurements, and good test-retest reliability was also reported in a fMRI study (Pujol et al, 1999). In contrast, unreliable test-retest repeatability of the results has been reported as one of the disadvantages of the Wada procedure (Grote et al, 1999;Meador and Loring, 1999;Bassel and Bradley, 2002).…”

Section: Discussionmentioning

confidence: 80%

“…Moreover, those tests, by being specific for the nondominant hemisphere, make it in fact 'dominant' for the function tested. In fTCD and fMRI studies, results are based on 'activation' (i.e., increase of blood flow velocity for fTCD and activated pixels for fMRI) and therefore most previous studies have mainly used widely accepted language specific tasks (Benson et al, 1999;Knecht et al, 1998;Lehericy et al, 2000). The study of FV fluctuations during the performance of successive specific for the nondominant hemisphere tasks could be an interesting avenue of future exploration.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Stability of Blood Flow over Time in the Dominant Hemisphere: A Functional Transcranial Doppler Study

Vadikolias

Artemis

Mitsias

et al. 2007

J Cereb Blood Flow Metab

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Functional transcranial Doppler (fTCD) has been used for the identification of cerebral hemispheric dominance in various cognitive tasks. In our study, we have used fTCD with the aim to compare blood flow patterns in the hemispheres not only during the task activation periods but also in the post-stimulus phase. Normal volunteers, 25 right and 25 left-handed, were included. Mean flow velocities (FVs) in the bilateral middle cerebral arteries were recorded during the performance of six cognitive tasks and during the intervals between tasks. The lateralization index (LI) was calculated separately for each test (LI1-6), on the basis of the percent change of blood FV from baseline. To estimate flow fluctuations, a novel index, the LI-variability, was also calculated using a formula constituted by the minimum and maximum mean values recorded at specific time intervals during the entire procedure. Laterization indices, LI-3 and LI-4, corresponding to word generation and reading aloud tasks, produced the highest degree of activation. A perfect agreement (Cohen's j = 1.000, P < 0.001) was observed among LI-3, LI-4, and LI-V. The repetition of recordings gave excellent test-retest reliability in 10 randomly selected participants. Our results suggest that the hemisphere that is characterized as dominant by fTCD maintains a more stable flow pattern during the performance of successive cognitive tasks. Although it could not be considered as a clinically useful tool as yet, this observation introduces a novel parameter such as the stability of blood flow over time, which could potentially provide insight in the study of cerebral functions.

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Reproducibility of Functional Transcranial Doppler Sonography in Determining Hemispheric Language Lateralization

Cited by 112 publications

References 35 publications

Functional Tissue Pulsatility Imaging of the Brain During Visual Stimulation

Functional Tissue Pulsatility Imaging of the Brain During Visual Stimulation

Cerebral lateralization and general intelligence: Gender differences in a transcranial Doppler study

Evaluation of the Stability of Blood Flow over Time in the Dominant Hemisphere: A Functional Transcranial Doppler Study

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