Reproducibility of forced expiratory flow and volume measurements in infants with bronchiolitis

Modl, Manfred; Eber, Ernst; Weinhandl, Elisabeth; Gruber, Wilfried; Zach, M

doi:10.1002/(sici)1099-0496(199912)28:6<429::aid-ppul8>3.3.co;2-v

Cited by 4 publications

(13 citation statements)

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“…These assumptions, however, might not be valid in the presence of airway obstruction. 22 Third, the variability of measurements obtained with these methods has been shown to be significantly higher than the one reported for the rapid thoracic compression techniques 1,8,15,17,22 ; less reproducible measurements, however, are more likely to be inefficient in the detection of modest lung function changes. The relatively high variability of forced expiratory flows, as obtained with the 4.5 ± 1.6 3.9 ± 1.5 4.5 ± 1.9 FEV 1.0 4.6 ± 1.9 3.8 ± 1.3 4.9 ± 1.5 Figure. There was no correlation between changes in FEV 0.5 after salbutamol inhalation and age.…”

Section: Discussionmentioning

confidence: 98%

“…[15][16][17] The aim of the current study was to investigate whether airway responsiveness to bronchodilator treatment in infants with acute viral bronchiolitis depends on age by measuring lung function with the RVRTC technique.…”

Section: Discussionmentioning

confidence: 99%

“…It follows that the RVRTC technique, with its considerable methodologic advantages over the other methods, provides the investigator with a more sensitive diagnostic tool for the assessment of therapeutic interventions. 1,[15][16][17] The pathophysiologic implications of the current findings focus on the relative contribution of bronchial smooth muscle constriction to early childhood wheezing. Lenney et al 11 speculated that the failure to document a significant response to bronchodilators under the age of 18 months might be due to age-dependent differences in the structure and function of airway smooth muscles and b-adrenergic receptors.…”

Section: Discussionmentioning

confidence: 99%

“…Measurements after placebo and bronchodilator inhalation were repeated until 5 to 7 acceptable curves were obtained. [15][16][17] The heart rate and the oxygen saturation of the infant were continuously monitored throughout the study procedure by a pulse oximeter.…”

Section: Study Protocolmentioning

confidence: 99%

“…The procedure and the equipment used have been described in detail previously. 1,17 Volume-time parameters, that is, forced expiratory volume after 0.5, 0.75, and 1 second of chest compression (FEV 0.5 , FEV 0.75 , and FEV 1.0 ), were used for the quantification of the forced expiratory maneuvers.…”

Section: Lung Function Measurementsmentioning

confidence: 99%

See 4 more Smart Citations

Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?

Modl

Eber

Malle-Scheid

et al. 2005

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Protocolmentioning

confidence: 99%

Section: Lung Function Measurementsmentioning

confidence: 99%

See 3 more Smart Citations

Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?

Modl

Eber

Malle-Scheid

et al. 2005

The Journal of Pediatrics

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Dynamic imaging of hyperpolarized3He distribution in rat lungs using interleaved-spiral scans

et al. 2000

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Assessment of Bronchodilator Responsiveness in Infants with Bronchiolitis

Modl¹,

Eber²,

Weinhandl³

et al. 2000

Am J Respir Crit Care Med

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Whether bronchodilators should be used for the treatment of infants with bronchiolitis is subject to debate, partly because of the low sensitivity of the methods for assessing lung function changes in infants. In the present study, we compared the recently introduced raised volume (RVRTC) with the conventional end-tidal rapid thoracoabdominal compression (ETRTC) technique in infants with acute viral bronchiolitis. In 17 infants lung function was assessed by both methods, at baseline values and after salbutamol inhalation. Forced expiratory volumes (FEV(0.5), FEV(0.75), FEV(1.0)) were used for the quantification of RVRTC measurement, and maximal expiratory flow at functional residual capacity (Vmax (FRC)) for ETRTC measurements. A significant individual change was defined by a mean postbronchodilator value that differed from baseline value by more than twice the within-subject coefficient of variation (CV). Group mean intrasubject CVs ranged from 4.7% to 5.3% for FEV parameters; it was 14.0% for Vmax (FRC). For the group, post-bronchodilator measurements did not differ significantly from baseline measurements. For the majority of infants, however, the within-subject comparison of responses revealed substantial differences between both techniques; while no infant demonstrated a significant increase in Vmax (FRC), eight (47%) infants responded with significantly improved timed volumes. The RVRTC technique provides the investigator with a more sensitive diagnostic tool for documenting the effectiveness of therapeutic interventions on an individual basis. Furthermore, the findings of the present study provide a rationale for the application of bronchodilators in a subgroup of infants with acute bronchiolitis.

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Reproducibility of forced expiratory flow and volume measurements in infants with bronchiolitis

Cited by 4 publications

References 0 publications

Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?

Does Bronchodilator Responsiveness in Infants with Bronchiolitis Depend on Age?

Dynamic imaging of hyperpolarized3He distribution in rat lungs using interleaved-spiral scans

Assessment of Bronchodilator Responsiveness in Infants with Bronchiolitis

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