Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: An intraobserver, interobserver, and interscan variability study

Cheng, Victor; Nakazato, Ryo; Dey, Damini; Gurudevan, Swaminatha V.; Tabak, Joshua; Budoff, Matthew J.; Karlsberg, Ronald P.; Min, James K.; Berman, Daniel S.

doi:10.1016/j.jcct.2009.07.001

Cited by 53 publications

(36 citation statements)

References 19 publications

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“…Bolus tracking with a region of interest placed in the ascending aorta and a preset threshold of 100 Hounsfield Units (HU) were used. The imaging parameters used were as follows: 120 kV for tube voltage, 600 mA for tube current with an ECG-based dose modulation whenever possible [39].…”

Section: Methodsmentioning

confidence: 99%

“…Accurate and reproducible quantitative measurements of coronary plaque volume may play a role in serial studies to determine disease progression or response to medical therapies [18]. Data on interscan reproducibility of coronary plaque detection are provided by two studies; so far they are limited to qualitative measurements in one study [38] and to manual quantitative measurements by two experienced observers in another [39]. Thus, our aim was to evaluate the interscan reproducibility of quantitative measurements of coronary plaque volume and composition from coronary CTA, using a standardized automated method.…”

Section: Introductionmentioning

confidence: 99%

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Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

et al. 2014

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

et al. 2014

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“…This information is needed to interpret changes in plaque volume over time. Previous studies (23)(24)(25) reported good interreader and intrareader coronary CT angiography reproducibility for assessment of calcified plaque in the proximal segments of the coronary tree; however, reproducibility was poor for assessment of noncalcified plaque, especially in distal segments of the coronary tree. Measurement of noncalcified plaque with coronary CT angiography is challenging because of the relatively poor softtissue contrast between soft plaque/ adventitia and surrounding fat tissue (26).…”

Section: Cardiac Imagingmentioning

confidence: 96%

Coronary CT Angiography: Variability of CT Scanners and Readers in Measurement of Plaque Volume

Symons¹,

Morris²,

Wu³

et al. 2016

Radiology

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Purpose:To determine reader and computed tomography (CT) scan variability for measurement of coronary plaque volume. Materials and Methods:This HIPAA-compliant study followed Standards for Reporting of Diagnostic Accuracy guidelines. Baseline coronary CT angiography was performed in 40 prospectively enrolled subjects (mean age, 67 years 6 6 [standard deviation]) with asymptomatic hyperlipidemia by using a 320-detector row scanner (Aquilion One Vision; Toshiba, Otawara, Japan). Twenty of these subjects underwent coronary CT angiography repeated on a separate day with the same CT scanner (Toshiba, group 1); 20 subjects underwent repeat CT performed with a different CT scanner (Somatom Force; Siemens, Forchheim, Germany [group 2]). Intraclass correlation coefficients (ICCs) and BlandAltman analysis were used to assess interreader, intrareader, and interstudy reproducibility. Results:Baseline and repeat coronary CT angiography scans were acquired within 19 days 6 6. Interreader and intrareader agreement rates were high for total, calcified, and noncalcified plaques for both CT scanners (all ICCs  0.96) without bias. Scanner variability was 618.4% (coefficient of variation) with same-vendor follow-up. However, scanner variability increased to 629.9% with different-vendor follow-up. The sample size to detect a 5% change in noncalcified plaque volume with 90% power and an a error of .05 was 286 subjects for same-CT scanner follow-up and 753 subjects with different-vendor follow-up. Conclusion:State-of-the-art coronary CT angiography with same-vendor follow-up has good scan-rescan reproducibility, suggesting a role of coronary CT angiography in monitoring coronary artery plaque response to therapy. Differences between coronary CT angiography vendors resulted in lower scanrescan reproducibility.q RSNA, 2016

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“…Inoue et al (2010) showed that statin treatment results in a decrease in the plaque and necrotic core volumes. In contrast, Cheng et al (2009) indicated that there were no associations between statin therapy and the contribution of CP, NCP, and MP. Unfortunately, we did not collect detailed information on medications, which could be very critical.…”

Section: Discussionmentioning

confidence: 88%

Association between Renal Dysfunction and the Mixed Plaque of Coronary Artery on Computed Tomographic Angiography

Sung

Chang

Chung

et al. 2011

Tohoku J. Exp. Med.

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Coronary artery plaque is related to development of coronary artery disease (CAD), and chronic kidney disease is associated with CAD. However, the association of renal dysfunction (RD) with coronary artery plaque characteristics has not been fully elucidated. We evaluated the association between RD and coronary artery plaque characteristics in patients with suspected CAD, who underwent multislice computed tomographic angiography (CTA). A total of 918 patients were classified into 4 groups: group with no plaque (NP) (48.9%), group with calcified plaque (CP) (16.0%), group with noncalcified plaque (NCP) (22.4%), and group with mixed plaque (MP) (12.7%). NCP is considered as rupture-prone soft plaque, and CP as more stable lesion. The mean of estimated glomerular filtration rate (eGFR) was 82.5 ± 15.4 mL/min/1.73m 2 , and the prevalence of RD (defined as eGFR < 60 mL/min/1.73m2 ) was 6.3%. The prevalence of RD was 3.3% in the NP group, 10.2% in the CP group, 5.3% in the NCP group, and 14.5% in the MP group (P < 0.001 by ANOVA tests). The adjusted odds ratio for RD was 3.38 (95% confidence interval, 1.27 -9.04) for the MP group, compared with the NP group. The presence of RD showed an independent association with the MP counts (r = 0.155, P < 0.001); however, there was no association between RD and other plaque characteristics. In conclusion, RD is associated with MP rather than CP or NCP, compared with NP, which may reflect one of the developmental processes of CAD in patients with RD.

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Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: An intraobserver, interobserver, and interscan variability study

Cited by 53 publications

References 19 publications

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Coronary CT Angiography: Variability of CT Scanners and Readers in Measurement of Plaque Volume

Association between Renal Dysfunction and the Mixed Plaque of Coronary Artery on Computed Tomographic Angiography

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