Reproducibility of compartmental modelling of 18F-FDG PET/CT to evaluate lung inflammation

Vass, Laurence; Lee, Sarah; Wilson, Frederick J. F.; Fisk, Marie; Cheriyan, Joseph; Wilkinson, Ian B.

doi:10.1186/s40658-019-0265-8

Cited by 4 publications

(3 citation statements)

References 31 publications

(36 reference statements)

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“…The proportions of air, blood and tissue will vary with disease and as a consequence of disease progression. To improve reproducibility in 18 F-FDG PET, standardisation of acquisition and analysis protocols are of paramount importance [11,32]. To that end, further work is currently being undertaken by a wide-ranging group of experts to provide recommendations on optimal protocols (manuscript in preparation [33]).…”

Section: Resultsmentioning

confidence: 99%

Advances in PET to assess pulmonary inflammation: A systematic review

Vass

Fisk

Lee³

et al. 2020

European Journal of Radiology

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Background: Respiratory diseases are one of the leading causes of death worldwide, yet effective treatment options remain limited. Although inflammation is thought to be a key driver in the pathogenesis and progression of several lung diseases, the underlying molecular mechanisms of lung dysfunction remain poorly understood. Imaging techniques may help to further our understanding of the pathophysiology and facilitate the translation of novel therapies. Positron Emission Tomography (PET) is a functional imaging technique which has the potential to interrogate the underlying inflammatory response. We present a systematic review of the literature summarising the emerging PET radiotracers developed to quantify pulmonary inflammation. Method: We performed a systematic review using the following databases: Medline, Embase, Scopus, PubMed, Web of Science and Cochrane. We included articles between 1995 and 2019 for all studies using PET radiotracers to evaluate inflammatory response in the lung. From a total of 911 articles covering both animal and human studies, two reviewers selected papers based on the inclusion/exclusion criteria and extracted data from 68 articles selected. Results: 53 out of 68 papers, including both human and animal studies, were eligible for synthesis. Heterogenous study populations and differences in study design, image acquisition and analysis made data pooling unfeasible; instead, we provide a narrative synthesis. Conclusions: Currently, very few novel radiotracers targeting lung inflammation have crossed the translational gap from animal models to human studies. Nevertheless, our results highlight a handful of promising tracers which warrant further evaluation in humans. 18 F-FDG has been investigated most extensively; although 18 F-FDG is not a specific inflammatory tracer, human studies of several pulmonary diseases support its use as a biomarker for inflammation. Despite ongoing debate about the optimal analysis methodology for 18 F-FDG lung images, standardisation of image acquisition and analysis should help to improve confidence in research outcomes. PET radiotracers can provide quantitative, targeted biomarkers which relate to the activity of molecular pathways and may expedite development of specific anti-inflammatory drugs.

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Section: Resultsmentioning

confidence: 99%

Advances in PET to assess pulmonary inflammation: A systematic review

Vass

Fisk

Lee³

et al. 2020

European Journal of Radiology

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“…Table 2 summarizes image analysis parameter reporting. Table 3 lists CM-specific parameters that the group recommends for reporting to promote reproducibility (56).…”

Section: Dynamic Data Analysis Dynamic Datasets Can Be Analyzed Usinmentioning

confidence: 99%

Consensus Recommendations on the Use of¹⁸F-FDG PET/CT in Lung Disease

et al. 2020

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Positron emission tomography (PET) with 18 F-fluorodeoxyglucose (18 F-FDG) has been increasingly applied, predominantly in the research setting, to study drug effects and pulmonary biology and monitor disease progression and treatment outcomes in lung diseases, disorders that interfere with gas exchange through alterations of the pulmonary parenchyma, airways and/or vasculature. To date, however, there are no widely accepted standard acquisition protocols and imaging data analysis methods for pulmonary 18 F-FDG PET/CT in these diseases, resulting in disparate approaches. Hence, comparison of data across the literature is challenging. To help harmonize the acquisition and analysis and promote reproducibility, acquisition protocol and analysis method details were collated from seven PET centers. Based on this information and discussions among the authors, the consensus recommendations reported here on patient preparation, choice of dynamic versus static imaging, image reconstruction, and image analysis reporting were reached.

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“…They found no significant differences between the groups but some variations in individual subjects between the two processing pipelines. They found blood ROI methodology, input function modeling, and time delay estimation to be key factors influencing the outcome (104).…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 99%