Reproducibility of Bruch Membrane Opening-Minimum Rim Width Measurements With Spectral Domain Optical Coherence Tomography

Park, Keunheung; Kim, Jinmi; Lee, Jiwoong

doi:10.1097/ijg.0000000000000787

Cited by 23 publications

(27 citation statements)

References 37 publications

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“…The currently estimated variance for volumes within occasions corresponds to previously published data (Park et al. ; Reis et al. ; Schrems‐Hoesl et al.…”

Section: Discussionsupporting

confidence: 79%

“…The currently estimated variance for volumes within occasions corresponds to previously published data (Park et al 2017;Reis et al 2017;Schrems-Hoesl et al 2018). Increasing the number of volumes averaged per occasion increases precision in follow-up comparisons within subject.…”

Section: Discussionsupporting

confidence: 61%

“…Commercially available automated algorithms are still under development. Manual review and correction is still required (Enders et al 2017;Park et al 2017;Reis et al 2017;Schrems-Hoesl et al 2018;Tun et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…A small number of recent studies report low variation for measuring the minimal cross section of the nerve fibre layer in the ONH. For normal and glaucomatous eyes, the variance for measurements of global BMO-MRW, calculated from estimates of within occasion measurement standard deviation, was 9 and 11 lm 2 , respectively (Park et al 2017). For glaucomatous eyes, the intra-and interobserver global BMO-MRW variance was 7 and 23 lm 2 , respectively (Reis et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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Purpose To estimate the sources of variation for Pigment epithelium central limit‐Inner limit of the retina Minimal Distance averaged over 2π (PIMD‐2π), and further to analyse their consequences for clinical measurements of glaucoma. Methods Forty subjects with early to moderate stage glaucoma were included. Three SD‐OCT volumes of the optic nerve head (ONH) were captured at two occasions. Each volume was segmented three times for PIMD‐2π. The magnitude of the sources of variation for PIMD‐2π measurements was estimated with an analysis of variance. Results A 95% confidence interval for mean PIMD‐2π was estimated to 215 ± 12 μm (df = 38). The estimated variance for subjects was 1280 μm2. The within‐subject estimated variance for occasions, volumes and segmentations was 10 μm2, 30 μm2 and 40 μm2, respectively. The within‐subject variances were used to model follow‐up of PIMD‐2π over time. A linear loss rate of 0.05 of baseline PIMD‐2π/year was assumed. A significant PIMD‐2π change could be detected in approximately 16–18 months with evenly spaced visits every 4 or 6 months. Conclusions Due to the small within‐subject estimated variances, a clinically undesirable PIMD‐2π change from baseline can be detected in approximately 18 months. Detection of significant PIMD‐2π loss in a subject requires knowledge of normal age loss and measurement variability.

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“…The currently estimated variance for volumes within occasions corresponds to previously published data (Park et al. ; Reis et al. ; Schrems‐Hoesl et al.…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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“… 27 , 28 One study found that an average of 11 out of 193 frames (or 5.7% of frames) examined in optic nerve volume scans had artifacts, 29 and studies of the BMO-MRW have reported artifacts in 62.6% to 84.0% of scans. 19 , 30 However, these papers did not analyze artifacts as a primary objective, and their different definitions, exclusion criteria, and methods of rate calculation make comparison to 2D artifacts challenging.…”

Section: Introductionmentioning

confidence: 99%

Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

Park

Tsikata

Lee

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified by the minimum distance band (MDB). Global MDB neuroretinal rim thicknesses were calculated before and after manual deletion of B-scans with artifacts and subsequent automated interpolation. A clinically significant artifact was defined as one requiring manual correction or repeat scanning. Results Among glaucomatous eyes, artifact rates per B-scan were significantly more common in RNFL scans (61.7%, 74 of 120) compared to B-scans in neuroretinal rim volume scans (20.9%, 1423 of 6820) (95% confidence interval [CI], 31.6–50.0; P < 0.0001). For clinically significant artifact rates per eye, optic nerve scans had significantly fewer artifacts (15.8% of glaucomatous eyes, 13.2% of normal eyes) compared to RNFL scans (61.7% of glaucomatous eyes, 25.4% of normal eyes) (glaucoma group: 95% CI, 34.1–57.5, P < 0.0001; normal group: 95% CI, 1.3–23.3, P = 0.03). Conclusions Compared to the most commonly used RNFL thickness scans, optic nerve volume scans less frequently require manual correction or repeat scanning to obtain accurate measurements. Translational Relevance This paper illustrates the potential for 3D OCT algorithms to improve in vivo imaging in glaucoma.

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Future Novel Imaging Methods

Shahidi

Felder

2020

Essentials in Ophthalmology

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Reproducibility of Bruch Membrane Opening-Minimum Rim Width Measurements With Spectral Domain Optical Coherence Tomography

Abstract: The Spectralis SD-OCT showed excellent reproducibility in BMO-MRW measurements in both normal and glaucoma subjects. The measurements variability was worse in more advanced glaucoma.

Cited by 23 publications

References 37 publications

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

Future Novel Imaging Methods

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