Reproducibility of asbestos body counts in digestions of autopsy and surgical lung tissue

Velasco-García, María-Isabel; Cruz, María Jesús; Ruano, Laura; Montero, María-Angeles; Freixa, Asunción; Ferrer, Jaume

doi:10.1002/ajim.20966

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…However, induced passive or active smoking could further magnify the risk. 40 Velasco-Garcia et al 41 also echoed through their study that about 0.8975: 0.8029 for autopsy samples and 0.9592 for biopsy samples cases of lung cancer had more than 5000 asbestos particles per gram of dry lung cancer. In another similar study of textile workers, heavy exposure to various types of asbestos-like crocidolite showed that the RR of lung cancer risk significantly increased in periods after employment with a standardized mortality ratio of 302, 363, and 278, respectively.…”

Section: Discussionmentioning

confidence: 87%

Relationship between Environmental Factors and Cancer: A Systematic Review on Environmental Carcinogens and Lung Cancer

Quazi¹,

Malik²

2022

Preprint

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The risk of lung cancer continues to elevate for both smokers and never-smokers. With the increasing morbidities and mortalities related to lung cancer, there is much interest on establishing other confounding factors that lead to lung cancer, other than smoking which is the most common cause. Some of the environmental factors have been identified as potential lung cancer causes. Therefore, the aim of this systematic review is to assess the relationship of environmental factors and lung cancer incidences by investigating various carcinogenic risks exposures that predispose an individual to lung cancer. The objective of this systematic review is thus to assess the evidence of relationship between environmental carcinogens and lung cancer incidence by systematically reviewing relevant studies. A standard criterion for the review methodology was formulated to guide the review process and data extraction. Online databases like PubMed, MEDLINE, Scopus (EMBASE), Google Scholar, Web of Science, and CINAHL were systematically searched for articles published between 2000 and 2021 that explored potential environmental carcinogens that were believed to expose occupational workers and individuals within the environment with lung cancer risks. 25 studies were eligible based on the selection criteria, and were finally included in the systematic review among which four were case-control studies, seven were cohorts, five was prospective, four were previous systematic reviews and four were systematic analysis. Chemical exposures like pesticides were analyzed for their carcinogenesis. Air pollution was also discussed with particulate and coal being the core of evidence of association with lung cancer. Second hand smoke, Asbestos, metal compounds like copper, PVC dust particles and ionizing radiations also provided evidence of environmental carcinogenesis associating to lung cancer cases.

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Section: Discussionmentioning

confidence: 87%

Relationship between Environmental Factors and Cancer: A Systematic Review on Environmental Carcinogens and Lung Cancer

Quazi¹,

Malik²

2022

Preprint

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“…134,136 These unsound restrictive pathology practices have resulted in declining many thousands of compensation claims of asbestos victims with significant financial savings for the manufacturers and users, particularly users of chrysotile asbestos. 111,112,134,[138][139][140][141][142][143][144][145][146] In recent years in Germany only 468 to 770 asbestos-related lung cancers per year were accepted although there were about 5,000 cases reported annually. These activities raise issues, not only relevant to Germany and other countries, but also relevant to the continuing widespread use of asbestos in some parts of the world and future compensation in many countries.…”

Section: Discussionmentioning

confidence: 99%

“…134,[138][139][140][141][142][143] Spain also has adopted fiber count criteria. 144,145 Switzerland, where there had been a considerable global asbestos cement industry, argued in 1975 that asbestosis should not be confirmed until asbestos was detected in lung tissues. 146 This has been further commented upon by Woitowitz.…”

Section: (Viii) International Spread Of Restrictive Asbestos-based Co...mentioning

confidence: 99%

The German experience with asbestos-related diseases: a failure of compensation due to the manipulation of science

Woitowitz,

Frank,

Baur

2023

The Journal of Scientific Practice and Integrity

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The world pandemic of asbestos-related diseases results from inadequate prevention and late bans on asbestos use. For years in Germany there has been an annual average of about ten thousand new claims. Many countries deny compensation due to unsound diagnostic applications that have entered into the literature and are used to deny compensation. One such well-established incorrect scientific strategy is the use of quantifying asbestos bodies or fibers in lung tissue and setting restrictive thresholds on the findings in tissues of workers who had been exposed primarily to chrysotile which shows low bio-persistence, movement to the pleura, and rarely forms asbestos bodies. The so called one thousand asbestos body hypothesis for the diagnosis of asbestosis, originating from the German Mesothelioma Register run by the employers’ statutory accident insurance institutions, has been applied in Germany and similarly in several other western countries. As opposed to the well-substantiated hit and run phenomena that has been predominantly applied to chrysotile asbestos, low asbestos body or fiber counts in tissue had been systematically misinterpreted. This, combined with restrictive histopathology definitions, have been used for the manipulation not only of diagnostic criteria but also of science and has had an effect on laws governing compensation. The counting of asbestos bodies or fibers in human lungs should under no circumstances invalidate a qualified occupational history of exposure as the hallmark requisite tool for assessing asbestos exposure and acceptance of asbestos-related diseases in compensation schemes. An outcome suggested by this paper is the need to broaden the WHO beneficial initiative to eliminate ARD worldwide by establishment of an international board of independent scientists on remedial action that would recommend standards for acknowledgement and compensation. Such a board should be supported by national legal branches recognizing possible regional differences and initiating compliance with the recommendations.

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Asbestos Bodies and Non-asbestos Ferruginous Bodies

Roggli

2013

Pathology of Asbestos-Associated Diseases

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Reproducibility of asbestos body counts in digestions of autopsy and surgical lung tissue

Abstract: Asbestos body counting by a single reader is a reliable method, especially at low concentrations of asbestos bodies in lung tissue. Double reading may be indicated in borderline cases with asbestos body levels close to levels of 1 000 AB/g.

Cited by 7 publications

References 17 publications

Relationship between Environmental Factors and Cancer: A Systematic Review on Environmental Carcinogens and Lung Cancer

Relationship between Environmental Factors and Cancer: A Systematic Review on Environmental Carcinogens and Lung Cancer

The German experience with asbestos-related diseases: a failure of compensation due to the manipulation of science

Asbestos Bodies and Non-asbestos Ferruginous Bodies

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