Reproducibility of a semi-automatic method for 6-point vertebral morphometry in a multi-centre trial

Guglielmi, Giuseppe; Stoppino, Luca Pio; Placentino, Maria Grazia; D’Errico, Francesco; Palmieri, Francesco

doi:10.1016/j.ejrad.2007.09.040

Cited by 30 publications

(15 citation statements)

References 17 publications

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“…Moreover, data on comorbidities are based on patients' reports without any further validation of objectivity. Finally, the fact that in this study no intraobserver repeatability testing was carried out, the accuracy in the centralized evaluation of vertebral deformities was assured by the use of a reproducible semiautomatic method recently validated by one of the authors (GG) [11]. The prevalence of unrecognized vertebral fractures (23%) in our study was higher than that observed in previous studies [35].…”

Section: Discussionmentioning

confidence: 56%

“…The characteristics and performance of MorphoXpress have been reported in detail in a recent paper by one of the authors (GG) [11]. In brief, MorphoXpress operates as follows: analysis is initialized by the manual targeting of the centers of upper and lower vertebrae to be analyzed.…”

Section: Assessment Of Vertebral Fracturesmentioning

confidence: 99%

“…The software then automatically finds the positions of landmarks for a standard six-point morphometry measurement. The software then allows these points to be moved by the operator, if deemed necessary, before the points are confirmed as being correct [11]. Then the anterior (Ha), midvertebral (Hm), and posterior (Hp) heights of each vertebra were measured and the three ratios, Ha/Hp, Hm/Hp, and Hp/Hp-below, were calculated.…”

Section: Assessment Of Vertebral Fracturesmentioning

confidence: 99%

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Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Nuti

Caffarelli

Guglielmi

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Osteoporosis, a multifactorial systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased bone fragility, is a worldwide public health problem. Vertebral fractures affect approximately 20% of postmenopausal women and are a hallmark of osteoporosis, but they may pass unnoticed, although they may lead to long-term immobility and disability. Questions/purposes The aims of the present study were (1) to determine the prevalence and the severity of vertebral fractures in a large cohort of Italian women aged 60 years or older with reduced values of quantitative ultrasound parameters; and (2) to assess whether vertebral fractures and other variables may be associated with health-related quality of life. Methods A total of 2450 women without back pain aged 60 years or older, after the completion of the Quality of Life Questionnaire of the European Foundation for Osteoporosis QUALEFFO, underwent quantitative ultrasound evaluation of the calcaneus; in those with a stiffness t-score of B À2 (n = 1194), radiographic evaluation of the thoracic and lumbar spine was carried out and then quantitative morphometry was performed by dedicated software (MorphoXpress). The radiographic analysis was carried out on 885 women who presented films of adequate quality. Multivariate regression was used to adjust for confounding variables. Results Of those who underwent radiographic analysis, 681 had no vertebral fractures, and 204 women (23.1%) had one or more previously undiagnosed vertebral fractures. The prevalence of previously undiagnosed vertebral fractures increased with advancing age with more than 30% of women older than 75 years having at least one fracture. Older age, body mass index, and severe vertebral fractures were independently associated with a worse total QUALEFFO score. Conclusions We found that approximately one in four women showed evidence of undiagnosed vertebral fractures, and there was a strong age effect trend. Moreover, the severity grade of vertebral fractures, more than the number of fractures, was associated with a worsening of healthrelated quality of life as assessed by QUALEFFO. These findings confirm the clinical relevance of an early diagnosis of vertebral fractures and seem to support the usefulness of quantitative ultrasound measurements in the stratification of postmenopausal women at increased fracture risk.

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Section: Discussionmentioning

confidence: 56%

Section: Assessment Of Vertebral Fracturesmentioning

confidence: 99%

Section: Assessment Of Vertebral Fracturesmentioning

confidence: 99%

See 1 more Smart Citation

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Nuti

Caffarelli

Guglielmi

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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“…Statistical correlation analysis showed that the resulting height of the 3D model for the observed vertebral body adequately represents the anterior, central, and posterior heights that were manually measured in 2D from the corresponding mid-sagittal CT cross section of the same vertebral body. The relatively small differences can be attributed to the accuracy in aligning the 3D model to vertebral bodies in 3D images and to the accuracy in manually identifying the anatomical points that define the three vertebral body heights in 2D images [35]. Moreover, it can be observed that the height, width, and length of the resulting 3D model for different segments of normal vertebral bodies correspond to the values reported in statistical studies of quantitative 3D vertebral anatomy [31][32][33].…”

Section: Discussionmentioning

confidence: 59%

Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D

et al. 2012

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“…• Anteroposterior and lateral radiography of the thoracic and lumbar spine was used to identify morphometrically detectable vertebral fractures. Six points defining the anterior, middle, and posterior heights were marked on each vertebra using a computed quantitative morphometer (MorphoXpress) [15]. The greatest percent reduction in height (Hpr) of the vertebral bodies was recorded, and the mean Hpr of the thoracic (T5-T12) and lumbar (L1-L4) spine were calculated.…”

Section: Methodsmentioning

confidence: 99%

Preventive effect of risedronate on bone loss and frailty fractures in elderly women treated with anastrozole for early breast cancer

et al. 2011

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The aim of this study was to assess the effect of adjuvant anastrozole, alone or associated with risedronate, on BMD and bone fracture risk in women more than 70 years old with hormone receptor-positive early breast cancer (EBC). In a group of 51 elderly women (aged 76.4 ± 5.0 years) considered for adjuvant aromatase inhibitors for EBC, 24 patients with T-scores ≥ -2 and no prevalent fractures received anastrozole 1 mg/day (group A), and 27 patients with T-scores < -2, or with T-scores ≥ -2 and prevalent fractures (group B), received anastrozole (1 mg/day) plus risedronate (35 mg/week). Both groups received supplementation with 1 g calcium carbonate and 800 IU vitamin D per day. Differences in BMD and frailty fractures were evaluated after 1 and 2 years. In group A, significant decreases in BMD were observed in the lumbar spine (Δ BMD, -0.030 ± 0.04 g/cm², P < 0.05), femoral neck (Δ BMD, -0.029 ± 0.05 g/cm², P < 0.05), and trochanter (Δ BMD, -0.026 ± 0.03 g/cm², P < 0.01) after 2 years. The greatest percent reduction in height (Hpr) emerged in the thoracic spine (3.6 ± 2.4%, P < 0.01), although only one incident vertebral fracture was observed. In group B, BMD increased in the lumbar spine (Δ BMD, 0.038 ± 0.04, P < 0.001), although no significant changes were seen in the hip regions. The decline in Hpr was negligible (about 1%). No incident fractures were observed at follow-up. In conclusion, anastrozole treatment for EBC in elderly women seems to have only mild negative effects on the femoral bone. Risedronate makes the use of anastrozole safer, even for osteopenic or osteoporotic elderly patients.

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Reproducibility of a semi-automatic method for 6-point vertebral morphometry in a multi-centre trial

Cited by 30 publications

References 17 publications

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Undiagnosed Vertebral Fractures Influence Quality of Life in Postmenopausal Women With Reduced Ultrasound Parameters

Quantitative vertebral morphometry based on parametric modeling of vertebral bodies in 3D

Preventive effect of risedronate on bone loss and frailty fractures in elderly women treated with anastrozole for early breast cancer

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