Reproducibility and variability of digital thermal monitoring of vascular reactivity

Ahmadi, Naser; McQuilkin, Gary L.; Akhtar, M. Wasy; Hajsadeghi, Fereshteh; Kleis, Stanley J.; Hecht, Harvey S.; Naghavi, Morteza; Budoff, Matthew J.

doi:10.1111/j.1475-097x.2011.01037.x

Cited by 28 publications

(30 citation statements)

References 28 publications

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“…The methodology for measuring endothelial function and vascular reactivity using DTM has been previously described [21–25]. All DTM tests were performed using a VENDYS® 6000 Portable System (Endothelix, Houston, TX), a PC-based system that fully automates the cuff reactive hyperemia protocol.…”

Section: Methodsmentioning

confidence: 99%

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry

Naghavi

Yen

Lin

et al. 2016

International Journal of Vascular Medicine

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Background. Endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity. Several studies showed digital thermal monitoring (DTM) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease. Objectives. To further evaluate the relations between patient characteristics and DTM indices in a large patient registry. Methods. DTM measures were correlated with age, sex, heart rate, and systolic and diastolic blood pressure in 6084 patients from 18 clinics. Results. DTM vascular reactivity index (VRI) was normally distributed and inversely correlated with age (r = −0.21, p < 0.0001). Thirteen percent of VRI tests were categorized as poor vascular reactivity (VRI < 1.0), 70 percent as intermediate (1.0 ≤ VRI < 2.0), and 17 percent as good (VRI ≥ 2.0). Poor VRI (<1.0) was noted in 6% of <50 y, 10% of 50–70 y, and 18% of ≥70 y. In multiple linear regression analyses, age, sex, and diastolic blood pressure were significant but weak predictors of VRI. Conclusions. As the largest database of finger-based vascular reactivity measurement, this report adds to prior findings that VRI is a meaningful physiological marker and reflects a high level of residual risk found in patients currently under care.

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Section: Methodsmentioning

confidence: 99%

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry

Naghavi

Yen

Lin

et al. 2016

International Journal of Vascular Medicine

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“…The device provides automated output, but reproducibility has not been evaluated in detail. 74 The Vendys system calculates the aTR based on the following equation: Temperature rebound = (Temp max − Temp pre occlusion)/Temp pre occlusion × 100%. This is done in an automated fashion.…”

Section: Novel Conceptsmentioning

confidence: 99%

Assessment and Prognosis of Peripheral Artery Measures of Vascular Function

Anderson¹,

Phillips²

2015

Progress in Cardiovascular Diseases

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“…66 Conversely, they were correlated in studies of cutaneous microvascular flow 67,68 and at the distal artery after occlusive hyperemia. 69 IR thermography had been used extensively when sources of thermal activity other than perfusion are involved, e.g., tumor metabolism, 15,[21][22][23]26 and thereby suited for IHs.…”

Section: Discussionmentioning

confidence: 99%

Infantile hemangioma status by dynamic infrared thermography: A preliminary study

et al. 2016

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Background Infantile hemangiomas (IH) are initially warm due to increased proliferation perfusion then involute with apoptosis and reduced perfusion. Objective quantitative evaluation of IH treatment response is essential for improving outcomes. We applied a functional imaging method, dynamic infrared (IR) thermography, to investigate IH status versus control skin and over time. Materials and Methods A preliminary prospective observational study was conducted among twenty-five subjects with superficial or mixed IHs (< 19 months) over 59 clinic visits. Infrared images of IHs and control sites, standardized color images and three-dimensional images were obtained. Tissue responses following application and removal of a cold stress were recorded with video IR thermography. Outcomes included areas under the curve during cooling (AUCcool) and rewarming (AUCrw) and thermal intensity distribution maps. Results AUCcool and AUCrw were significantly higher and cooling rate slower for IHs versus uninvolved tissue indicating greater heat, presumably due to greater perfusion and metabolism for the IH. IR distribution maps showed specific areas of high and low temperature. Significant changes in IH thermal activity were reflected in the difference (AUCcool – AUCrw), with 6.2 at 2.2 months increasing to 37.6 at 12.8 months. IH cooling rate increased with age, indicating slower recovery, and interpreted as reduced proliferation and/or involution. Conclusions Dynamic IR thermography was a well-tolerated, quantitative functional imaging modality appropriate for the clinic, particularly when structural changes, i.e., height, volume, color, were not readily observed. It may assist in monitoring progress, individualizing treatment and evaluating therapies.

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Reproducibility and variability of digital thermal monitoring of vascular reactivity

Abstract: In a controlled environment, the repeatability of DTM is excellent. DTM can be used as a reproducible and operator-independent test for non-invasive measurement of vascular function.

Cited by 28 publications

References 28 publications

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry

Assessment and Prognosis of Peripheral Artery Measures of Vascular Function

Infantile hemangioma status by dynamic infrared thermography: A preliminary study

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