Reprint of: Transcranial direct current stimulation (tDCS) – Application in neuropsychology

Shin, Yong‐Il; Foerster, Águida; Nitsche, Michael A.

doi:10.1016/j.neuropsychologia.2015.06.021

Cited by 53 publications

(34 citation statements)

References 172 publications

(136 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[16,17]). Importantly, it has also been used in numerous studies for exploring the physiological foundations of cognitive functions [18,19], including EFs in both healthy individuals [20e22] and patients with executive dysfunctions related to frontal abnormalities [23e26]. With respect to overall efficacy and directionality of effects, these tDCS studies have resulted in heterogeneous outcomes, with reasons that are not yet completely understood [27e29].…”

Section: Introductionmentioning

confidence: 99%

Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: According to the neurocognitive model of addiction, the development and maintenance of drug addiction is associated with cognitive control deficits, as well as decreased activity of prefrontal regions, especially the dorsolateral prefrontal cortex (DLPFC). This study investigated how improving executive functions (EFs) impacts methamphetamine-use disorder, which has been less explored compared to craving, but might be a central aspect for the therapeutic efficacy of DLPFC stimulation in drug addiction. Methods: We assessed the efficacy of 10 repeated sessions of transcranial direct current stimulation (tDCS) over the DLPFC on executive dysfunctions in methamphetamine-use disorder, and its association with craving alterations. 39 of 50 initially recruited individuals with methamphetamine-use disorder who were in the abstinent-course treatment were randomly assigned to "active" and "sham" stimulation groups in a randomized, double-blind parallel-group study. They received active (2 mA, 20 min) or sham tDCS for 10 sessions over 5 weeks. Performance on major EF tasks (e.g., working memory, inhibitory control, cognitive flexibility, and risk-taking behaviour) and craving were measured before, immediately after, and 1 month following the intervention. Participants reported abstinence from drug consumption throughout the experiment, verified by regular urine tests during the course of the study up to the follow-up measurement. Results: The group which received active DLPFC tDCS showed significantly improved task performance across all EFs immediately after and 1 month following the intervention, when compared to both prestimulation baseline and individuals who received sham tDCS. Similarly, a significant reduction in craving was observed immediately after and 1 month following the intervention in the active, but not sham stimulation group. A significant correlation between cognitive control improvement and craving reduction was found as well.

show abstract

Section: Introductionmentioning

confidence: 99%

Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…While prior research has found that different tDCS dosing paradigms can produce differential neuromodulatory and behavior effects (Alonzo, Brassil, Taylor, Martin, & Loo, 2012; Chew, Ho, & Loo, 2015; Coffman, Trumbo, & Clark, 2012; Hoy, Arnold, Emonson, Daskalakis, & Fitzgerald, 2014; Teo, Hoy, Daskalakis, & Fitzgerald, 2011), it remains to be determined the exact mechanisms that could lead to differential or similar cognitive outcomes. Indeed, the neurocognitive effects of tDCS are moderated by a combination of tDCS parameters (e.g., anode and cathode electrode placement, current intensity, duration), patient demographic factors, and the neurocognitive task (Brunoni et al, 2016b; Shen, Foerster, & Nitsche, 2015). Further, different tDCS parameter configurations could produce unique underlying brain changes that could mediate clinical and cognitive outcomes (Lisanby, 2017; Sellers et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial

et al. 2020

View full text Add to dashboard Cite

Objective Transcranial direct current stimulation (tDCS) has been found to have antidepressant effects and may have beneficial neurocognitive effects. However, prior research has produced an unclear understanding of the neurocognitive effects of repeated exposure to tDCS. The study's aim was to determine the neurocognitive effects following tDCS treatment in participants with unipolar or bipolar depression. Method The study was a triple‐masked, randomized, controlled clinical trial across six international academic medical centers. Participants were randomized to high dose (2.5 mA for 30 min) or low dose (0.034 mA, for 30 min) tDCS for 20 sessions over 4 weeks, followed by an optional 4 weeks of open‐label high dose treatment. The tDCS anode was centered over the left dorsolateral prefrontal cortex at F3 (10/20 EEG system) and the cathode over F8. Participants completed clinical and neurocognitive assessments before and after tDCS. Genotype (BDNF Val66Met and catechol‐o‐methyltransferase [COMT] Val158Met polymorphisms) were explored as potential moderators of neurocognitive effects. Results The study randomized 130 participants. Across the participants, tDCS treatment (high and low dose) resulted in improvements in verbal learning and recall, selective attention, information processing speed, and working memory, which were independent of mood effects. Similar improvements were observed in the subsample of participants with bipolar disorder. There was no observed significant effect of tDCS dose. However, BDNF Val66Met and COMT Val158Met polymorphisms interacted with tDCS dose and affected verbal memory and verbal fluency outcomes, respectively. Conclusions These findings suggest that tDCS could have positive neurocognitive effects in unipolar and bipolar depression. Thus, tDCS stimulation parameters may interact with interindividual differences in BDNF and COMT polymorphisms to affect neurocognitive outcomes, which warrants further investigation.

show abstract

“…For instance, in Horvath and colleagues' systematic reviews (2015a, 2015b; see also Dedoncker et al, 2016) reliable effects of tDCS were obtained only over a peripheral neurophysiological measure -motor evoked potentials -but not on more central measures such as in fMRI or EEG data. However, other systematic reviews highlight the potential efficacy of tDCS in a variety of measures and conditions (e.g., Joyal & Fecteau, 2016;Kekic et al, 2016;Shin et al, 2015). In fact, there have been some indications that tDCS may modulate neural activity.…”

Section: Discussionmentioning

confidence: 99%

“…But their neural and behavioral efficacy has recently been challenged (e.g., Buzsáki, 2016;Dedoncker, Brunoni, Baeken, & Vanderhasselt, 2016;Horvath, Forte & Carter, 2015a, 2015b; but see Antal, Keeser, Priori, Padberg, & Nitsche, 2015;Joyal & Fecteau, 2016;Kekic, Boysen, Campbell, & Schmidt, 2016;Shin, Foerster, & Nitsche, 2015). Specifically, Buzsáki has suggested that the typical tDCS stimulation parameters used in neuroscientific research are underpowered, as the application of an electric current to the skull of a cadaver, following such parameters, fails to elicit any neural firing in adjacent brain cells (Buzsáki, 2016).…”

Section: Introductionmentioning

confidence: 99%

Polarity-specific transcranial direct current stimulation effects on object-selective neural responses in the inferior parietal lobe

Almeida

Martins

Bergström

et al. 2017

Cortex

View full text Add to dashboard Cite

Neuromodulation techniques such as transcranial direct current stimulation (tDCS) are routinely used for treating neurological and neuropsychiatric disorders, and for enhancement of cognitive abilities. Recently, their effectiveness in modulating behavioral and neural responses has been questioned. Here we use excitatory and inhibitory tDCS prior to a functional magnetic resonance imaging (fMRI) experiment to show that neural responses for an area's preferred stimuli depend on the polarity of stimulation. This is an important, yet overlooked, data point in demonstrating the effectiveness of these stimulation techniques. Our results show that response preferences in the target area are dependent on the polarity of the tDCS session preceding the fMRI experiment - these preferences are less distinct in the cathodal than in the anodal session. As such, we show unequivocally that tDCS modulates neural responses. This result is of the utmost importance in demonstrating the effectiveness of tDCS for clinical and experimental purposes.

show abstract

Reprint of: Transcranial direct current stimulation (tDCS) – Application in neuropsychology

Cited by 53 publications

References 172 publications

Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study

Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study

Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial

Polarity-specific transcranial direct current stimulation effects on object-selective neural responses in the inferior parietal lobe

Contact Info

Product

Resources

About