Reprint of “Biogenesis and adhesion of type 1 and P pili”

Lillington, James; Geibel, Sebastian; Waksman, Gabriel

doi:10.1016/j.bbagen.2014.07.009

Cited by 9 publications

(17 citation statements)

References 102 publications

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“…The assembly of a complete tip fibrillum requires the subsequent sequential addition of a single molecule of FimG and FimF for type 1 pili; and one molecule of PapF, 5-10 molecules of PapE and one molecule of PapK for P pili. The vast majority of the pilus length is formed by the rod, which is composed of ~1000 copies of a single subunit (FimA or PapA for type 1 or P pili, respectively) 5 (FIG. 1a).…”

Section: Cu Pilus Biogenesismentioning

confidence: 99%

“…They are organised into two subassemblies -a short, thin tip fibrillum mounted on a 1-2 µm long, helically wound rod 5 (FIG. 1a).…”

Section: Cu Pilus Biogenesismentioning

confidence: 99%

“…UPEC elaborates two types of pili, type 1 and P pili 5 , which will be used here as paradigms to highlight the structure and assembly of surface organelles assembled by the CU pathway.…”

Section: Introductionmentioning

confidence: 99%

“…They are important virulence factors that facilitate host-pathogen interactions crucial for the establishment and persistence of an infection and for other key processes such as biofilm formation 1,5 . The role of CU pili in the pathogenesis of urinary tract infections (UTIs) caused by uropathogenic…”

Section: Introductionmentioning

confidence: 99%

“…Bacterial attachment may involve contact between the bacterium and host tissues during infection, between bacteria and other surfaces or between bacteria themselves 3 . In the case of conjugative pili, bacterial contact between donor and acceptor bacteria enables the transport of DNA from one cell to another, whereas contact mediated through other types of pili may lead to infection, bacterial motility, microcolony or biofilm formation 1, [4][5][6][7] . This review will focus on the diverse structures and functions of the assembly machineries involved in the biogenesis of the five known types of pili/fimbriae in Gram-negative bacteria: the Chaperone-Usher (CU) pili, the type IV pili (T4P), the conjugative type IV secretion pili, the curli fibres, and the more recently described type V pili.…”

mentioning

confidence: 99%

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A comprehensive guide to pilus biogenesis in Gram-negative bacteria

2017

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Pili are critical virulence factors of many Gram-negative pathogens. These surface structures provide bacteria with a link to their outside environments, allowing bacteria to interact with their hosts, other surfaces or with each other. They can even provide a conduit for the exchange of information. The surface chemistries and other biophysical properties of pili are uniquely adapted to the environmental challenges faced by bacteria. The assembly of these surface structures presents a molecular engineering challenge, which bacteria have solved in a variety of unique ways. In this review, we examine recent advances in our structural understanding of various Gram-negative pilus systems and discuss their functional implications.

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Section: Cu Pilus Biogenesismentioning

confidence: 99%

“…They are organised into two subassemblies -a short, thin tip fibrillum mounted on a 1-2 µm long, helically wound rod 5 (FIG. 1a).…”

Section: Cu Pilus Biogenesismentioning

confidence: 99%

“…UPEC elaborates two types of pili, type 1 and P pili 5 , which will be used here as paradigms to highlight the structure and assembly of surface organelles assembled by the CU pathway.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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A comprehensive guide to pilus biogenesis in Gram-negative bacteria

2017

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Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

Lu,

Wang,

Wang

et al. 2023

Phytotherapy Research

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Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires global action. The occurrence of bacterial pathogens with multi‐drug resistance appeals to exploring alternative therapeutic strategies. Antivirulence treatment has been a positive substitute in seeking to circumvent AMR, which aims to target virulence factors directly to combat bacterial infections. Accumulated evidence suggests that plant‐derived natural products, which have been utilized to treat infectious diseases for centuries, can be abundant sources for screening potential virulence‐arresting drugs (VADs) to develop advanced therapeutics for infectious diseases. This review sums up some virulence factors and their actions in various species of bacteria, as well as recent advances pertaining to plant‐derived natural products as VAD candidates. Furthermore, we also discuss natural VAD‐related clinical trials and patents, the perspective of VAD‐based advanced therapeutics for infectious diseases and critical challenges hampering clinical use of VADs, and genomics‐guided identification for VAD therapeutic. These newly discovered natural VADs will be encouraging and optimistic candidates that may sustainably combat AMR.

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Adhesins During Infection

Krachler

Orth²

2018

Reference Module in Biomedical Sciences

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Reprint of “Biogenesis and adhesion of type 1 and P pili”

Cited by 9 publications

References 102 publications

A comprehensive guide to pilus biogenesis in Gram-negative bacteria

A comprehensive guide to pilus biogenesis in Gram-negative bacteria

Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

Adhesins During Infection

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