Repressions of MMP-9 expression and NF-κB localization are involved in inhibition of lung carcinoma 95-D cell invasion by (–)-epigallocatechin-3-gallate

Yang, Jingya; Wei, Dongzhi; Liu, Jianwen

doi:10.1016/j.biopha.2005.01.004

Cited by 42 publications

(32 citation statements)

References 18 publications

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“…It has also been reported that the oxidative stress in a human epithelial lens cell line (Yao et al, 2009) and in lung carcinoma 95-D cells (Yang et al, 2005) affected the MMP-9 transcription by inhibiting the activation and translocation of NF-kB. Accordingly, it is reasonable to state that EGCG reduced MMP-9 transcription in HTLV-1-positive cell lines by inhibiting the NF-kB nuclear translocation.…”

Section: Discussionmentioning

confidence: 86%

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Harakeh¹,

Diab‐Assaf²,

Azar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 86%

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Harakeh¹,

Diab‐Assaf²,

Azar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…These data suggest that the preparation might signifi cantly attenuate tumor progression by blocking MMP-9 synthesis. The main polyphenol from green tea, EGCG, likewise the polyphenols tested, was able to decrease MMP-9 expression in 95-D lung carcinoma cells at the concentration of 40 μmol/L [Yang et al, 2005], whereas in periodontal diseases it was effective even at the concentration of only 20 μmol/L [Yun et al, 2004].…”

Section: Discussionmentioning

confidence: 93%

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors

Szewczyk¹,

Lewandowska²,

Owczarek³

et al. 2014

Pol. J. Food Nutr. Sci.

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Key words: evening primrose, matrix metalloproteinases, cancer Evening primrose (Oenothera paradoxa Hudziok) seeds are a rich source of not only a valuable oil containing an essential fatty acid --linolenic acid (GLA) -but also polyphenols which can be obtained from the biomass remaining after oil pressing. The aim of our studies was to evaluate the infl uence of a polyphenol extract from defatted seeds of evening primrose on human colorectal adenocarcinoma Caco-2 cell proliferation and matrix metalloproteinases (MMPs) synthesis and activity. To assess the effect of evening primrose extract on Caco-2 cell proliferation, crystal violet staining and sulforhodamine B (SRB) assays were used whereas mRNA expression and activity of MMPs were evaluated by RT-PCR and gelatin zymography.The results revealed that the examined polyphenol extract had little infl uence on Caco-2 proliferation, but effectively in a time-and dose-dependent manner inhibited MMP-1, MMP-7, MMP-9 and MMP-14 mRNA synthesis induced by TNF- and TPA. Additionally, zymographic analysis revealed that after 24 h, the polyphenol extract at a concentration of 50 mol/L GAE caused a 10-fold reduction in MMP-9 synthesis. Moreover, this extract might be a potent inhibitor of MMP activity. The results showed that polyphenol extract from evening primrose inhibited PBMC-derived MMP-2 and MMP-9 enzymatic activity in dose-dependent manner. The obtained results indicate that the polyphenol extract from evening primrose seeds could be an inhibitor of proteases involved in tumor progression and metastasis.

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“…When AH109A cells were co-cultured with a rat mesentery-derived mesothelial cell (M-cell) monolayer in the presence of sera from rats orally administrated with EGCG, the ROS-potentiated invasion of AH109A across the M-cell monolayer was significantly inhibited [84]. In lung cancer, EGCG repressed the expression of MMP-9 and diminished the localization of nuclear NF-kB, which attenuated the invasion of lung carcinoma 95-D cells [85]. In BZR bronchial tumor cells, EGCG inhibited migration and the expression of MMP-2 and vimentin, suggesting that EGCG could be an attractive candidate to treat lung cancer invasion [86].…”

Section: Egcg Egc Ecg and Ecmentioning

confidence: 99%

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities

Weng

Yen

2012

Cancer Metastasis Rev

190

128

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Cancer metastasis refers to the spread of cancer cells from the primary neoplasm to distant sites, where secondary tumors are formed, and is the major cause of death from cancer. Natural phytochemicals containing phenolic compounds have been widely demonstrated to have the capability to prevent cancer metastasis. Among phenolic compounds, flavonoids are a very large subclass, and they are abundant in food and nutraceuticals. The number of reports demonstrating that flavonoids are an effective natural inhibitor of cancer invasion and metastasis is increasing in the scientific literature. Catechin derivatives, (−)-epigallocatechin-3-gallate, (−)-epigallocatechin, (−)-epicatechin-3-gallate,and (−)-epicatechin, are the most studied compounds in this topic so far; genistein/genistin, silibinin, quercetin, and anthocyanin have also been widely investigated for their inhibitory activities on invasion/metastasis. Other flavonoids in dietary vegetable foods that are responsible for anti-invasive and anti-metastatic activities of tumors include luteolin,apigenin, myricetin, tangeretin, kaempferol, glycitein, licoricidin,daidzein, and naringenin. To effectively overcome the metastatic cascade, including cell-cell attachment, tissue barrier degradation, migration, invasion, cell-matrix adhesion,and angiogenesis, it is essential that a bioactive compound prevent tumor cells from metastasizing. This review summarizes the effects of flavonoids on the metastatic cascade and the related proteins, the in vitro anti-invasive activity of flavonoids against cancer cells, and the effects of flavonoids on antiangiogenic and in vivo anti-metastatic models. The available scientific evidence indicates that flavonoids are a ubiquitous dietary phenolics subclass and exert extensive in vitro anti-invasive and in vivo anti-metastatic activities.

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Repressions of MMP-9 expression and NF-κB localization are involved in inhibition of lung carcinoma 95-D cell invasion by (–)-epigallocatechin-3-gallate

Cited by 42 publications

References 18 publications

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities

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