Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer

Shozu, Kanto; Kaneko, Syuzo; Shinkai, Norio; Dozen, Ai; Kosuge, Hirofumi; Nakakido, Makoto; Machino, Hidenori; Takasawa, Ken; Asada, Ken; Komatsu, Masaaki; Tsumoto, Kouhei; Ohnuma, Shin-ichi; Hamamoto, Ryuji

doi:10.1186/s13148-022-01370-z

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…The protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been investigated in the pathogenesis of Hutchinson-Gilford progeria, psoriatic and rheumatoid arthritis, bladder cancer and respiratory tract infections [50]. ADORA2B gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily.…”

Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

Preprint

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Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell disease (SCD) affecting 6-10% of adult SCD patients. Various mechanisms and theories have been evaluated to explain the pathophysiology of the disease. However, questions remain, particularly regarding the clinical heterogeneity of the disease in terms of symptoms, complications, and survival. Beyond the classical mechanisms that have been thoroughly investigated and include hemolysis, nitric oxide availability, endothelial disorders, thrombosis, and left heart failure, attention is focused nowadays on the potential role of the genes involved in such processes. Potential candidate genes are investigated through next-generation sequencing, with the TGF-β pathway being the initial target. This field of research may also provide novel targets for pharmacologic agents in the future as is already the case with idiopathic PH. The collection and processing of data and samples from multiple centers can yield safe results that will allow a better understanding of SCD-related PH as a part of the disease’s clinical spectrum. The following review attempts to capture the most recent findings of studies on gene polymorphisms that have been associated with PH in SCD patients.

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Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been investigated in the pathogenesis of Hutchinson-Gilford progeria, psoriatic and rheumatoid arthritis, bladder cancer, and respiratory tract infections [61]. The ADORA2B gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily.…”

Section: Role Of Gene Polymorphisms In Pathogenesis and Prognosis Of ...mentioning

confidence: 99%

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Chatzidavid,

Flevari,

Tombrou

et al. 2024

IJMS

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is a progressive and potentially fatal complication of sickle cell disease (SCD), affecting 6–10% of adult SCD patients. Various mechanisms and theories have been evaluated to explain the pathophysiology of this disease. However, questions remain, particularly regarding the clinical heterogeneity of the disease in terms of symptoms, complications, and survival. Beyond the classical mechanisms that have been thoroughly investigated and include hemolysis, nitric oxide availability, endothelial disorders, thrombosis, and left heart failure, attention is currently focused on the potential role of genes involved in such processes. Potential candidate genes are investigated through next-generation sequencing, with the transforming growth factor-beta (TGF-β) pathway being the initial target. This field of research may also provide novel targets for pharmacologic agents in the future, as is already the case with idiopathic PH. The collection and processing of data and samples from multiple centers can yield reliable results that will allow a better understanding of SCD-related PH as a part of the disease’s clinical spectrum. This review attempts to capture the most recent findings of studies on gene polymorphisms that have been associated with PH in SCD patients.

show abstract

“…Among chromatin remodelers, histone deacetylases (HDACs) can create a condensed chromatin structure that significantly mediates transcriptional repression by removing acetyl groups from histones, which reduces their electrostatic charges, thus enhancing DNA binding . Extensive research studies have indicated a close association between aberrant levels of HDACs and the development and progression of various diseases, including cancer. − Therefore, accurate monitoring and measurement of HDACs are crucial for the diagnosis, treatment, and screening of HDAC-related cancer …”

Section: Introductionmentioning

confidence: 99%

DNA–Peptide Interaction-Modulated Charge Reversal in Biomimetic Nanochannels for Simple and Efficient Detection of Histone Deacetylases

Shi,

Ying,

Sha

et al. 2024

Anal. Chem.

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Protein acetylation, a fundamental post-translational modification, plays a critical role in the regulation of gene expression and cellular processes. Monitoring histone deacetylases (HDACs) is important for understanding epigenetic dynamics and advancing the early diagnosis of malignancies. Here, we leverage the dynamic characteristics of DNA−peptide interactions in biomimetic nanochannels to develop a HDAC detection method. In specific, the catalysis of peptide deacetylation by HDACs triggers alterations in the charge states of the nanochannel surface to accommodate DNA molecules. Then, the interaction between DNA and peptides shifts the nanochannel surface charge from positive to negative, leading to a reversal of the ion current rectification (ICR). By calculation of the ICR ratio, quantitative detection of HDACs can be efficiently achieved using the nanochannel-based method in an enzyme-free and label-free manner. Our experimental results demonstrate that HDACs can be detected by using this method within a concentration range of 0.5−500 nM. The innate simplicity and efficiency of this strategy may render it a valuable tool for advancing both fundamental research and clinical applications in the realm of epigenetics and personalized medicine.

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Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer

Cited by 6 publications

References 67 publications

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology

DNA–Peptide Interaction-Modulated Charge Reversal in Biomimetic Nanochannels for Simple and Efficient Detection of Histone Deacetylases

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