“…AgNPs have multiple effects, for example, AgNPs induce neuronal differentiation in human neuroblastoma cells [26,27] and AgNPs induce cell death through generation of reactive oxygen species, which is a major cause of nanoparticles-induced cell death in a variety of cancer cells including human breast cancer cells [28], human lung cancer cells [29] and human ovarian cancer cells [30]. Besides these, AgNPs induce cytotoxicity, alterations in signaling pathways [31,32], mitochondrial dysfunction [33], production of reactive oxygen species (ROS), depletion of various antioxidants, increased lipid peroxidation and accumulation of autophagosomes [34], inflammasome formation [35], apoptosis, and necrosis [36]. Frequent exposure to AgNPs from different products leads to an accumulation of AgNPs in the body and subsequently in the brain after crossing the blood brain barrier (BBB) [37,38].…”