Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners

Chang, Chir-Weei; Chen, Chao-Yen; Yen, Chih‐Feng; Wu, Yu Tse; Hsu, Mei‐Chich

doi:10.3390/nu10091318

Cited by 10 publications

(10 citation statements)

References 63 publications

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“…On the other hand, the impact of acute exercise on the hemoglobin and hematocrit values remains unclear [61]. Most of the available studies, both clinical [61][62][63] and preclinical [64], reported transient decreases in these values due to plasma volume expansion, whereas others found no changes in them after exercise [65,66]. Here, probably due to the timing of sampling (16 h after the exercise bout), the protocol applied did not modify the blood erythrocyte counts, the hemoglobin concentration, or the hematocrit.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

et al. 2022

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Intensive acute exercise can induce oxidative stress, leading to muscle damage and immune function impairment. Cocoa diet could prevent this oxidative stress and its consequences on immunity. Our aim was to assess the effect of a cocoa-enriched diet on the reactive oxygen species (ROS) production by peritoneal macrophages, blood immunoglobulin (Ig) levels, leukocyte counts, and the physical performance of rats submitted to an intensive acute exercise, as well as to elucidate the involvement of cocoa fiber in such effects. For this purpose, Wistar rats were fed either a standard diet, i.e., a diet containing 10% cocoa (C10), or a diet containing 5% cocoa fiber (CF) for 25 days. Then, half of the rats of each diet ran on a treadmill until exhaustion, and 16 h later, the samples were obtained. Both C10 and CF diets significantly prevented the increase in ROS production. However, neither the cocoa diet or the cocoa fiber-enriched diet prevented the decrease in serum IgG induced by acute exercise. Therefore, although the cocoa-enriched diet was able to prevent the excessive oxidative stress induced by intensive exercise, this was not enough to avoid the immune function impairment due to exercise.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

et al. 2022

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“…After 6 weeks of intensive exercise, trained rats had a higher number of blood leukocytes and, after exhaustion, there was a decrease in the erythrocyte counts and hemoglobin concentration, which could be due to the hemodilution induced by plasma volume expansion in the recovery period [ 57 ]. None of the experimental diets prevented the changes in red and white blood cells.…”

Section: Discussionmentioning

confidence: 99%

Influence of Diets Enriched with Flavonoids (Cocoa and Hesperidin) on the Systemic Immunity of Intensively Trained and Exhausted Rats

et al. 2022

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The aim of this study was to establish the influence of flavonoid-enriched diets on the immune alterations induced by an intensive training and a final exhaustion test in rats. A flavanol-enriched diet (with 10% cocoa, C10 diet) and a flavanol and flavanone-enriched diet (C10 plus 0.5% hesperidin, CH diet) were used. Lewis rats were fed either a standard diet, C10 diet or CH diet while they were submitted to an intensive running training on a treadmill. After 6 weeks, samples were obtained 24 h after performing a regular training (T groups) and after carrying out a final exhaustion test (TE groups). The C10 diet attenuated the increase in plasma cortisol induced by exhaustion, while both the C10 and the CH diets prevented the alterations in the spleen Th cell proportion. The experimental diets also induced an increase in serum immunoglobulin concentration and an enhancement of spleen natural killer cytotoxicity, which may be beneficial in situations with a weakened immunity. Most of the effects observed in the CH groups seem to be due to the cocoa content. Overall, a dietary intervention with flavonoids enhances immune function, partially attenuating the alterations in systemic immunity induced by intensive training or exhausting exercise.

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“…The main active ingredient is also identified as the water-soluble polysaccharide, and it has been prepared as an injectable dosage form (commercially available) [ 26 ] or coupled with iron complexes [ 27 ] for facilitating HGB recovery and better treatment. However, ASR and AR are more often prescribed in combination since according to the theory of traditional Chinese medicine, the recipe is able to deliver synergic efficacies by raising the “q” (vital energy) as well as nourishing the “blood” (body circulation) of a person [ 28 ]. Studies have shown that combined ASR and AR could stimulate the growth and inhibit the apoptosis of bone marrow stromal cells [ 15 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport

Chang

Wang

Liu

et al. 2021

IJERPH

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In the fight against sports doping, the Athlete Biological Passport (ABP) system aims to indirectly unveil the doping incidents by monitoring selected biomarkers; however, several unexplored extrinsic factors may dampen a fair interpretation of ABP profiles. Chinese herbal medicine (CHM) plays a pivotal role in the health care system, and some remedies have a long history of being used to treat anaemia. In this study, we addressed the concerns of whether the CHM administration could yield a measurable effect on altering the ABP haematological variables. Forty-eight healthy volunteers were randomly assigned to receive two-week oral administration of one of the six selected CHM products that are commonly prescribed in Taiwan (eight subjects per group). Their blood variables were determined longitudinally in the phases of baseline, intervention, and recovery over 5 weeks. Blood collection and analyses were carried out in strict compliance with relevant operating guidelines. In the groups receiving Angelicae Sinensis Radix, Astragali Radix, and Salviae Miltiorrhizae Radix et Rhizoma, a significant increased reticulocyte percentage and decreased OFF-hr Score were manifested during the intervention, and such effects even sustained for a period of time after withdrawal. All other variables, including haemoglobin and Abnormal Blood Profile Score, did not generate statistical significance. Our results show that the use of CHM may impact the ABP haematological variables. As a consequence, we recommend athletes, particularly those who have been registered in the testing pool, should be aware of taking specific Chinese herbal-based treatment or supplementation, and document any of its usage on the anti-doping forms.

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Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners

Cited by 10 publications

References 63 publications

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

Influence of Diets Enriched with Flavonoids (Cocoa and Hesperidin) on the Systemic Immunity of Intensively Trained and Exhausted Rats

Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport

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