Representation of Sounds in Auditory Cortex of Awake Rats (Dissertation)

Hromádka, Tomáš

doi:10.1038/npre.2008.2464

Cited by 1 publication

(2 citation statements)

References 105 publications

(193 reference statements)

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“…Correct licks were rewarded with water, incorrect licks were discouraged with a mild air puff and a short (1–3 second) time out (see 47 for details on training and other task details). The stimulus consisted of a train of 10 clicks (20 Hz, 5 ms duration, 58 dB SPL RMS, 73 dB SPL peak value) followed either by a non-target (pure tone, 100msec, 24000Hz) or a target (amplitude-modulated warble, 6000Hz carrier, 78 dB SPL RMS, 86 dB SPL peak) stimulus.…”

Section: Methodsmentioning

confidence: 99%

“…In the engaged-auditory condition, head-fixed subjects performed an auditory Go/No-Go task in which they were required to lick a water spout after presentation of a target sound and to refrain from licking after presentation of a distractor sound. Correct licks were rewarded with water, incorrect licks were discouraged with a mild air puff and a short (1–3 second) time out (see 47 for details on training and other task details). The stimulus consisted of a train of 10 clicks (20 Hz, 5 ms duration, 58 dB SPL RMS, 73 dB SPL peak value) followed either by a non-target (pure tone, 100msec, 24000Hz) or a target (amplitude-modulated warble, 6000Hz carrier, 78 dB SPL RMS, 86 dB SPL peak) stimulus.…”

Section: Methodsmentioning

confidence: 99%

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Engaging in an auditory task suppresses responses in auditory cortex

et al. 2009

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Although systems involved in attentional selection have been studied extensively, much less is known about non-selective systems. To study these preparatory mechanisms, we compared activity in auditory cortex elicited by sounds while rats performed an auditory task (“engaged”) with activity elicited by identical stimuli while subjects were awake but not performing a task (“passive”). Surprisingly, we found that engagement suppressed responses, an effect opposite in sign to that elicited by selective attention. In the auditory thalamus, however, engagement enhanced spontaneous firing rates but did not affect evoked responses. These results demonstrate that in auditory cortex, neural activity cannot be viewed simply as a limited resource allocated in greater measure as the state of the animal passes from somnolent to passively listening to engaged and attentive. Instead the engaged condition possesses a characteristic and distinct neural signature in which sound-evoked responses are paradoxically suppressed.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%