Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models
Robert E. Hynds,
Ariana Huebner,
David R. Pearce
et al.
Abstract:Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-region tumor sampling increased successful PDX engraftment and most models were histologically similar to their parent tumor. Whole-exome sequencing enabled comparison of tumors and PDX models and we provide an adapted mouse reference genome for improved removal of NOD scid gamm… Show more
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