Repositioning pinacidil and its anticonvulsant and anxiolytic properties in murine models
Artur Teixeira Pereira,
Érica Aparecida Gelfuso,
Rene Oliveira Beleboni
Abstract:Epilepsy, frequently comorbid with anxiety, is a prevalent neurological disorder. Available drugs often have side effects that hinder adherence, creating a need for new treatments. Potassium channel activators have emerged as promising candidates for treating both epilepsy and anxiety. This study aimed to evaluate the potential anticonvulsant and anxiolytic effects of pinacidil, an ATP-sensitive potassium channel activator used as antihypertensive, in rats. Our results indicate that pinacidil at 10 mg/kg (i.p.… Show more
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