Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
Jian-wen Di,
Yi-xin Wang,
Rui-xue Ma
et al.
Abstract:V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VISTA agonistic antibody could significantly improve asthma symptoms. Thus, for allergic asthma treatment, VISTA targeting may be a compelling approach. In this study, we examined the functional mechanism of VISTA in allergic pulmonary inflammation and screened the FDA-approved drugs for VISTA agonists. By us… Show more
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