Reporting Terminology for Brain Arteriovenous Malformation Clinical and Radiographic Features for Use in Clinical Trials

Neuroradiology, Therapeutic; Atkinson, Richard; Awad, Issam A.; Batjer, H. Hunt; Dowd, Christopher F.; Furlan, Andrea D.; Giannotta, Steven L.; Gomez, Camilo R.; Gress, Dustin A.; Hádemenos, George J.; Halbach, Van V.; Hemphill, J. Claude; Higashida, R T; Hopkins, L. Nelson; Horowitz, Mary; Johnston, Steven; Lawton, Michael; McDermott, Michael W.; Malek, Adel M.; Mohr, J. P.; Qureshi, Adrian I.; Riina, Howard A.; Smith, Warren S.; Pile‐Spellman, John; Spetzler, Robert F.; Tomsick, Thomas A.; Young, William L.

doi:10.1161/01.str.32.6.1430

Cited by 166 publications

(46 citation statements)

References 33 publications

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“…Aneurysms are defined as saccular or fusiform luminal dilatations of the parent feeding vessel, without regard to size [31]. Various classifications have been proposed for AVM-related aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study

Shotar

Pistocchi²,

Haffaf³

et al. 2017

Cerebrovasc Dis

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Background: Brain arteriovenous malformations (BAVMs) are a leading cause of intracranial hemorrhage in young adults. This study aimed to identify individual predictive factors of early rebleeding after BAVM rupture and determine its impact on prognosis. Methods: Early rebleeding was defined as a spontaneous intracranial hemorrhage within 30 days of BAVM rupture in patients with nonobliterated BAVMs. One hundred fifty one patients with 158 BAVM hemorrhagic events admitted to a tertiary care center during 14 years were included. Univariate followed by multivariate logistic regression was performed to assess the impact of early rebleeding on in-hospital mortality and modified Rankin Scale (mRS) score beyond 3 months and to identify independent predictors of early rebleeding. Results: Eight early rebleeding events were observed, 6 of which occurred during the first 7 days. Early rebleeding was independently and significantly associated with poor outcome (mRS ≥3 beyond 3 months, p = 0.004) but not with in-hospital mortality (p = 0.9). Distal flow-related aneurysms (p = 0.009) and altered consciousness with a Glasgow coma scale score of 3 (p = 0.01) were independently associated with early rebleeding. Conclusions: Early rebleeding is a severe complication that can occur after BAVM-related hemorrhage. Distal flow-related aneurysms and initial altered consciousness are associated with early rebleeding.

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Section: Discussionmentioning

confidence: 99%

Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study

Shotar

Pistocchi²,

Haffaf³

et al. 2017

Cerebrovasc Dis

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show abstract

“…BAVM diagnosis, morphological and clinical characteristics were recorded using standardised definitions. 16 The diagnosis of AVM was confirmed locally at each site by digital subtraction angiography, pathology, and/ or MR or CT angiography. Patients with known diagnoses of HHT or other Mendelian vascular disorders were excluded.…”

Section: Methods Study Population and Designmentioning

confidence: 99%

Genome-wide association study of sporadic brain arteriovenous malformations

Weinsheimer

Bendjilali

Nelson

et al. 2016

J Neurol Neurosurg Psychiatry

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Background-The pathogenesis of sporadic brain arteriovenous malformations (BAVM) remains unknown, but studies suggest a genetic component. We estimated the heritability of sporadic BAVM and performed a genome-wide association study (GWAS) to investigate association of common single-nucleotide polymorphisms (SNPs) with risk of sporadic BAVM in the international, multicenter Genetics of Arteriovenous Malformation (GEN-AVM) consortium.

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“…), and angioarchitectural features were scored according to a structured format based on recommendations from the Joint Writing Group. 1 All patients with an AVM receive two-dimensional digital subtraction angiography performed at fast film rates. Initial CT and MR imaging were also examined by a neurointerventional radiologist to identify any current or prior intracranial hemorrhage.…”

Section: Methodsmentioning

confidence: 99%

Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage

Alexander

Cooke

Nelson³

et al. 2015

AJNR Am J Neuroradiol

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Background and Purpose Intracranial hemorrhage is the most serious outcome for brain arteriovenous malformations (AVM). This study examines associations between venous characteristics of these lesions and intracranial hemorrhage. Materials and Methods Statistical analysis was performed on a prospectively maintained database of brain AVMs evaluated at an academic medical center. DSA, CT, and MRI studies were evaluated to classify lesion side, drainage pattern, venous stenosis, number of draining veins, venous ectasia, and venous reflux. Logistic regression analyses were performed to identify association of these angiographic features with intracranial hemorrhage of any age at initial presentation. Results Exclusively deep drainage (OR 3.42, 95% CI 1.87–6.26, p<0.001) and a single draining vein (OR 1.98, 95% CI 1.26–3.08, p=0.002) were associated with hemorrhage, whereas venous ectasia (OR 0.52, 95% CI 0.34–0.78, p=0.002) was inversely associated with hemorrhage. Conclusion Analysis of venous characteristics of brain AVMs may help determine their prognosis and thereby identify lesions most appropriate for treatment.

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Reporting Terminology for Brain Arteriovenous Malformation Clinical and Radiographic Features for Use in Clinical Trials

Abstract: “If you wish to converse with me,” said Voltaire, “define your terms.” How many a debate would have been deflated into a paragraph if the disputants had dared to define their terms! Will Durant: The Story of Philosophy

Cited by 166 publications

References 33 publications

Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study

Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study

Genome-wide association study of sporadic brain arteriovenous malformations

Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage

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