Reporting Psychiatric Disease Characteristics in Post-Mortem- and Biological Research
Karel Scheepstra,
Mark Mizee,
Dennis Wever
et al.
Abstract:Inflammation is a prominent hypothesis in the neurobiology of depression. In our transcriptomic profiling study of microglia in chronic major depressive disorder (MDD), we revealed a distinct disease-associated microglia (DAM) transcriptomic profile exclusively found in cortical gray matter, that we have designated DepDAM. These DepDAM revealed an immune-suppressed state, with a possible upstream mechanism for microglial suppression, by upregulation of CD200 and CD47 (“don’t eat me signals”) located on synapse… Show more
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