Reporting of Drug Trial Funding Sources and Author Financial Conflicts of Interest in Cochrane and non-Cochrane Meta-analyses: A Cross-sectional Study

Abstract

Background: A previous study found that 2 of 29 (6.9%) meta-analyses published in high-impact journals in 2009 reported included drug trials’ funding sources, and none reported trial authors’ financial conflicts of interest (FCOIs) or industry employment. It is not known if reporting has improved since 2009. Our objectives were to (1) investigate the extent to which pharmaceutical industry funding and author-industry FCOIs and employment from included drug trials are reported in meta-analyses published in high-impact journals; and (2) compare current reporting with results from 2009.Methods: We searched PubMed (January 2017 – October 2018) for systematic reviews with meta-analyses including ≥ 2 randomized controlled trials (RCTs) of patented drugs. We included 3 meta-analyses published January 2017-October 2018 from each of 4 high-impact general medicine journals, high-impact journals from 5 specialty areas, and the Cochrane Database of Systematic Reviews, as in the previous study. Results: Among 29 meta-analyses reviewed, 13 of 29 (44.8%) reported the funding source of included trials compared to 2 of 29 (6.9%) in 2009, a difference of 37.9% (95% confidence interval, 15.7% to 56.3%); this included 7 of 11 (63.6%) from general medicine journals, 3 of 15 (20.0%) from specialty medicine journals, and 3 of 3 (100%) Cochrane reviews. Only 2 of 29 meta-analyses (6.9%) reported trial author FCOIs, and none reported trial author-industry employment.Protocol Publication: (https://osf.io/8xt5p/) Limitations: We examined only a relatively small number of meta-analyses from selected high-impact journals and compared results to a similarly small sample from an earlier time period.Conclusions: Reporting of drug trial sponsorship and author FCOIs in meta-analyses published in high-impact journals has increased since 2009 but is still suboptimal. Standards on reporting of trial funding described in the forthcoming revised PRISMA statement should be adapted and enforced by journals to improve reporting.

Reporting of financial conflicts of interest in meta-analyses of drug trials published in high-impact medical journals: comparison of results from 2017 to 2018 and 2009

“…We evaluated 3 Cochrane reviews, and all 3 reported trial funding sources, but only 1 of 3 provided information on author-industry financial ties from included trials. A recent study [52] that investigated the extent to which recently published meta-analyses reported trial funding, authorindustry financial ties, and author-industry employment from included RCTs found that reporting of trial funding in Cochrane meta-analyses increased from 30% (46 of 151 reviews) in 2010 to 84% (90 of 107) in 2016-2018. Reporting of trial author-industry financial ties increased from 7% (11 of 151) in 2010 to 44% (47 of 107) in 2016-2018, which suggests that this could still improve.…”