Abstract:In the fall of 2018, news broke about a researcher from China who had used CRISPR gene editing to cause human babies to have a deletion in the CCR5 chemokine receptor, making them resistant to HIV infection. One of the numerous ethical concerns about this study is that the deletion may have other effects. Subsequently, Nature Medicine published a Brief Communications from Wei and Nielsen concluding that homozygotes for the CCR5-∆32 deletion have a survival probability to age 76 of 83.5% compared to 86.5% and 8… Show more
“…In summary, our analyses show no evidence that Δ32/Δ32 individuals have increased mortality rates. Similar findings have also been reported in other recent manuscripts [7][8][9] . This provides a case example of the subtle pitfalls that can produce false positive results, even in an extraordinarily high-quality and relatively uniformly generated dataset such as the UK Biobank.…”
Peer review information Kate Gao was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team.
“…In summary, our analyses show no evidence that Δ32/Δ32 individuals have increased mortality rates. Similar findings have also been reported in other recent manuscripts [7][8][9] . This provides a case example of the subtle pitfalls that can produce false positive results, even in an extraordinarily high-quality and relatively uniformly generated dataset such as the UK Biobank.…”
Peer review information Kate Gao was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team.
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