Reported Alcohol Consumption and Cognitive Decline: The Northern Manhattan Study

Wright, Clinton B.; Elkind, Mitchell S.V.; Luo, Xiaodong; Paik, Myunghee Cho; Sacco, Ralph L.

doi:10.1159/000096300

Cited by 30 publications

(26 citation statements)

References 66 publications

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“…Data were collected through interviews by trained bilingual research assistants using standardized data collection instruments [17,24,25] . Educational level was used as an indicator of socioeconomic status (SES) and classified into 2 categories: 'Less than eighth-grade education' included those who never went to high school and 'more than eighth-grade education' was used as the reference.…”

Section: Risk Factors and Covariatesmentioning

confidence: 99%

Race-Ethnic Differences of Sleep Symptoms in an Elderly Multi-Ethnic Cohort: The Northern Manhattan Study

Ramos¹,

Wohlgemuth²,

Dong³

et al. 2011

Neuroepidemiology

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Background: Sleep disorders are associated with stroke and may vary among elderly Hispanics, Blacks and Whites. We evaluated differences in sleep symptoms by race-ethnicity in an elderly population-based urban community sample. Methods: Snoring, daytime sleepiness and reported sleep duration were ascertained by standardized interviews as a part of the Northern Manhattan Study, a prospective cohort study of vascular risk factors and stroke risk in a multi-ethnic urban population. Sleep symptoms were compared amongst race-ethnic groups using logistic regression models. Results: A total of 1,964 stroke-free participants completed sleep questionnaires. The mean age was 75 ± 9 years, with 37% men, with 60% Hispanics, 21% Blacks and 19% Whites. In models adjusted for demographic and vascular risk factors, Hispanics had increased odds of frequent snoring (odds ratio, OR: 3.6, 95% confidence interval, CI: 2.3–5.8) and daytime sleepiness (OR: 2.8, 95% CI: 1.7–4.5) compared to White participants. Hispanics were more likely to report long sleep (≧9 h of sleep, OR: 1.8, 95% CI: 1.1–3.1). There was no difference in sleep symptoms between Black and White participants. Conclusion: In this cross-sectional analysis among an elderly community cohort, snoring, sleepiness and long sleep duration were more common in Hispanics. Sleep symptoms may be surrogate markers for an underlying sleep disorder which may be associated with an elevated risk of stroke and may be modified by clinical intervention.

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Section: Risk Factors and Covariatesmentioning

confidence: 99%

Race-Ethnic Differences of Sleep Symptoms in an Elderly Multi-Ethnic Cohort: The Northern Manhattan Study

Ramos¹,

Wohlgemuth²,

Dong³

et al. 2011

Neuroepidemiology

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“…A number of recent articles have shown that older adults who drink alcohol at light to moderate levels have better cognitive performance [31] , reduced rates of cognitive decline in late adulthood and a reduced risk of dementia [32] . Drawing from research on alcohol and cardiovascular disease [33] , several authors have concluded that for older adults, alcohol consumption in low to moderate doses may in fact be beneficial for the brain and cognition.…”

Section: Level Of Ability Versus Rate Of Change In Ability Over Timementioning

confidence: 99%

Alcohol Exposure and Cognitive Development: An Example of Why We Need a Contextualized, Dynamic Life Course Approach to Cognitive Ageing – A Mini-Review

Anstey

2008

Gerontology

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Background: A substantial literature exists that demonstrates associations between putative risk factors and cognitive decline in late life. However, there is a need to integrate this broad literature within a framework that incorporates the interaction of behavioral and ecological influences with cognitive development. Such a framework is required for developing a range of personal and environmental interventions to optimize cognitive development in the population, and to reduce the risk of cognitive impairment in late life. Objective: This review aims to identify the key considerations for developing a life course model of the various factors that influence cognitive development and cognitive decline. A contextualized, dynamic approach to life course epidemiology is proposed. Methods: A theoretical evaluation of key methodological and interpretational issues relating to how risk factors influence cognitive development and cognitive impairment was conducted. This focused on the example of alcohol consumption as a risk factor for cognitive decline and dementia. Results: This review identified dimensions that need to be accounted for in life course theories of cognitive development and cognitive impairment. These include: (a) intergenerational influences; (b) methodological and interpretational issues; (c) individual differences (personal factors); (d) contextual factors (environmental or ecological factors), and (e) cognitive ability as determinant. The methodological and interpretational factors included measurement of exposure and outcome variables; the important distinction between level of ability versus change over time; nonlinear relationships among exposures and outcomes, and outcomes and age; the distinction between association and cause, and between short-term effects and long-term change. Conclusion: A contextualized, dynamic approach to life course epidemiology accounts for the complex range of influences over the life course that interact to determine normal and pathological cognitive ageing. This approach provides a framework for the development of interventions to maximize cognitive gains in early life, and minimize cognitive loss in late life.

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“…The number of APOE e4 alleles carried by each subject was determined by HhaI digestion of PCR products amplified from genomic DNA. 22 …”

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confidence: 99%

Sleep disturbances and cognitive decline in the Northern Manhattan Study

et al. 2016

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Objective: To examine frequent snoring, sleepiness, and sleep duration with baseline and longitudinal performance on neuropsychological (NP) battery. Methods:The analysis consists of 711 participants of the Northern Manhattan Study (NOMAS) with sleep data and NP assessment (age 63 6 8 years, 62% women, 18% white, 17% black, 67% Hispanic) and 687 with repeat NP testing (at a mean of 6 6 2 years). The main exposures were snoring, sleepiness, and sleep duration obtained during annual follow-up. Using factor analysis-derived domain-specific Z scores for episodic memory, language, executive function, and processing speed, we constructed multivariable regression models to evaluate sleep symptoms with baseline NP performance and change in performance in each NP domain.

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Reported Alcohol Consumption and Cognitive Decline: The Northern Manhattan Study

Cited by 30 publications

References 66 publications

Race-Ethnic Differences of Sleep Symptoms in an Elderly Multi-Ethnic Cohort: The Northern Manhattan Study

Race-Ethnic Differences of Sleep Symptoms in an Elderly Multi-Ethnic Cohort: The Northern Manhattan Study

Alcohol Exposure and Cognitive Development: An Example of Why We Need a Contextualized, Dynamic Life Course Approach to Cognitive Ageing – A Mini-Review

Sleep disturbances and cognitive decline in the Northern Manhattan Study

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