Reporte de cuatro casos clínicos de bacteriemia por Hafnia alvei en una unidad cardio-quirúrgica pediátrica

Abstract

Introduction:The gram negative bacillus Hafnia alvei, is the only species of the genus Hafnia, family Enterobacteriaceae. It occasionally behaves as an opportunistic pathogen in humans, causing intestinal and respiratory infection and sepsis. It rarely causes bacteremia, usually of unknown focus. Objective: To describe a nosocomial outbreak of four pediatric patients with bacteremia by Hafnia alvei. Methods: Descriptive study using clinical records of pediatric patients diagnosed with Hafnia alvei bacteremia in a pediatric cardiosurgical unit, in October 2008. Results: The attack rate was 4/8 (50%), lethality rate 2/4 (50%) and mortality 2/8 (25%). The microbiological study and pulsed-field gel electrophoresis confirmed the same clonal bacterial strain. Discussion: The source of bacteremia was identified only in two patients and was associated with central venous catheters. The other two cases had no known infectious source. Epidemiological surveillance of emerging agents must be maintained.

"Hafnia alvei Urinary Tract Infection in A Patient with Multimorbidity After Covid19 - A Case Report"

“…In earlier studies, its connection to the clinical infection is debated [5] but after 2000, there is an increasing number of case reports in which Hafnia alvei is involved in human infections. For example, Hafnia alvei is reported to cause complicated [6][7][8][9] and uncomplicated UTIs [11], bacteremia and sepsis [12][13][14][15][16][17][18][19][20][21][22][23], hemolytic uremic syndrome [24], peritonitis [25,26], chorioamnionitis and preterm birth [27], deep infection in open fractures [28],…”

First report of a carbapenemase OXA-48-producing Hafnia alvei clinical isolate

“…In humans, H. alvei is a normal inhabitant of the intestinal tract, although some researchers also consider it a commensal of the respiratory tract [5]. It has been shown to be predominantly associated with several intestinal disorders, including gastroenteritis and also extraintestinal disorders (bacteraemia, pneumonia) [6][7][8][9]. Its role in infectious pathology is becoming more frequent due to better identification in microbiology laboratories [10][11][12][13].…”