Reporte de caso de transmisión vertical de la infección por virus chikungunya

Cardona-Correa, Sara E.; Castaño-Jaramillo, Lina María; Quevedo-Vélez, A.

doi:10.4067/s0370-41062017000200015

Cited by 13 publications

(13 citation statements)

References 10 publications

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“…Most patients recover within 2 weeks, but complications can result in debilitating sequelae persisting for years after viral clearance. Recent reports have implicated CHIKV in cases of acute encephalomyelitis (6, 7) similar to that of "New World" equine encephalitis alphaviruses, and the capability for vertical transmission during pregnancy or birth (8,9) has been demonstrated. Currently, no United States Food and Drug Administration-approved treatments for CHIKV have been approved for civilian use.…”

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confidence: 99%

Functional and structural characterization of the chikungunya virus translational recoding signals

Kendra¹,

Advani

Chen³

et al. 2018

Journal of Biological Chemistry

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Climate change and human globalization have spurred the rapid spread of mosquito-borne diseases to naïve populations. One such emerging virus of public health concern is chikungunya virus (CHIKV), a member of the Togaviridae family, genus Alphavirus. CHIKV pathogenesis is predominately characterized by acute febrile symptoms and severe arthralgia, which can persist in the host long after viral clearance. CHIKV has also been implicated in cases of acute encephalomyelitis, and its vertical transmission has been reported. Currently, no FDA-approved treatments exist for this virus. Recoding elements help expand the coding capacity in many viruses and therefore represent potential therapeutic targets in antiviral treatments. Here, we report the molecular and structural characterization of two CHIKV translational recoding signals: a termination codon read-through (TCR) element located between the nonstructural protein 3 and 4 genes and a programmed ؊1 ribosomal frameshift (؊1 PRF) signal located toward the 3 end of the CHIKV 6K gene. Using Dual-Luciferase and immunoblot assays in HEK293T and U87MG mammalian cell lines, we validated and genetically characterized efficient TCR and ؊1 PRF. Analyses of RNA chemical modification data with selective 2-hydroxyl acylation and primer extension (SHAPE) assays revealed that CHIKV ؊1 PRF is stimulated by a tightly structured, triple-stem hairpin element, consistent with previous observations in alphaviruses, and that the TCR signal is composed of a single large multibulged hairpin element. These findings illuminate the roles of RNA structure in translational recoding and provide critical information relevant for design of live-attenuated vaccines against CHIKV and related viruses.

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mentioning

confidence: 99%

Functional and structural characterization of the chikungunya virus translational recoding signals

Kendra¹,

Advani

Chen³

et al. 2018

Journal of Biological Chemistry

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“…Three of the eight infants died including two infants with necrotizing enterocolitis [62]. In Segovia, Colombia, a vertically infected infant developed fever, rash and respiratory distress requiring ventilator support [136]. The patient fully recovered with no long-term sequelae reported at the six-month follow-up [136].…”

Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Barr

Vaidhyanathan

2019

Viruses

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Chikungunya virus (CHIKV) was first extensively described in children during outbreaks in India and South Asia during the mid-1960s. Prior to the 2005 emergence of CHIKV on Reunion Island, CHIKV infection was usually described as a dengue-like illness with arthralgia in Africa and febrile hemorrhagic disease in Asia. Soon after the 2005 emergence, severe CNS consequences from vertical and perinatal transmission were described and as CHIKV continued to emerge in new areas over the next 10 years, severe manifestation of infection and sequelae were increasingly reported in infants and neonates. The following review describes the global reemergence and the syndromes of Chikungunya fever (CHIKF) in infants and children. The various manifestations of CHIKF are described and connected to the viral lineage that was documented in the area at the time the disease was described. The data show that certain manifestations of CHIKF occur with specific viral lineages and genetic motifs, which suggests that severe manifestations of CHIKF in the very young may be associated with the emergence of new viral lineages.

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“…CHIKV congenital infections were first reported during the 2005 outbreak on Reunion Island [5][6][7]. After the emergence of CHIKV in the Western Hemisphere, multiple reports of congenital infections were published that documented neurological complications, cardiac defects, respiratory distress, and miscarriage [5,8,9]. Although reports of congenital infection were published in many CHIKV-endemic locations, the vast majority originated from South and Central America [4].…”

Section: Introductionmentioning

confidence: 99%

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Schultz

Jones

Barr

2020

Viruses

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Chikungunya virus (CHIKV) is an alphavirus that causes febrile illness punctuated by severe polyarthralgia. After the emergence of CHIKV in the Western Hemisphere, multiple reports of congenital infections were published that documented neurological complications, cardiac defects, respiratory distress, and miscarriage. The Western Hemisphere is endemic to several alphaviruses, and whether antigenic cross-reactivity can impact the course of infection has not been explored. Recent advances in biomedical engineering have produced cell co-culture models that replicate the cellular interface at the maternal fetal axis. We employed a trans-well assay to determine if cross-reactive antibodies affected the movement and replication of CHIKV across placental cells and into an embryoid body. The data showed that antibodies to Venezuelan equine encephalitis virus significantly reduced CHIKV viral load in embryoid bodies. The data highlighted the fact that viral pathogenesis can be cell-specific and that exploiting antigenic cross-reactivity could be an avenue for reducing the impact of congenital CHIKV infections.

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Reporte de caso de transmisión vertical de la infección por virus chikungunya

Cited by 13 publications

References 10 publications

Functional and structural characterization of the chikungunya virus translational recoding signals

Functional and structural characterization of the chikungunya virus translational recoding signals

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

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