Report Summary - Congenital Anomalies in Canada 2013: A Perinatal Health Surveillance Report by the Public Health Agency of Canada’s Canadian Perinatal Surveillance System

Irvine, Brittany; Luo, W.; Ja, León Leal

doi:10.24095/hpcdp.35.1.04

Cited by 56 publications

(54 citation statements)

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“…3,4 The Canadian Congenital Anomalies Surveillance System reported a prevalence for OFC of 1.46 cases per 1000 total live births and stillbirths for Ontario from 1998 to 2007, with a slight decline of CL and CLP rates. 29 Our reported incidence of OFC and its subgroups was lower than previously reported across Canada, and to our knowledge, this is the first study to report that the incidences of OFC and CP are declining. A 2014 study by Lowry et al 30 reported a slightly increased rate of CL and CLP but a significant decrease of CP.…”

Section: Incidence Of Ofc and Its Variationcontrasting

confidence: 48%

Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada

Malic

Lam²,

Donelle

et al. 2020

JAMA Netw Open

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IMPORTANCE Orofacial cleft (OFC) is one of the most common congenital malformations, with a wide variation in incidence worldwide. However, population-based studies on the incidence of OFC in North America are lacking. OBJECTIVES To examine the incidence of OFC in Ontario, Canada, and to compare risk factors and mortality associated with children with OFC vs children without OFC. DESIGN, SETTING, AND PARTICIPANTS This population-based retrospective cohort study used health administrative data from the province of Ontario, Canada. Children with OFC who were born from April 1, 1994, to March 31, 2017, in Ontario were each matched to 5 children without OFC based on sex, date of birth (±30 days), and mother's age (±5 years). Analyses were conducted from September 2018 to January 2019. EXPOSURES Children born with OFC. MAIN OUTCOMES AND MEASURES Incidence of OFC over time and regional variation. Risk factors for OFC were assessed using 1-way analysis of variance for means, Kruskal-Wallis for medians, and χ 2 tests for categorical variables. Adjusted Cox regression models were used to assess mortality.

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Section: Incidence Of Ofc and Its Variationcontrasting

confidence: 48%

Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada

Malic

Lam²,

Donelle

et al. 2020

JAMA Netw Open

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“…33 Declining incidence trends for malignant gonadal germ cell tumors accords with the reduction in prevalence of congenital anomalies. 20,58…”

Section: Discussionmentioning

confidence: 99%

Childhood cancer incidence in Canada: demographic and geographic variation of temporal trends (1992–2010)

Xie

Onysko

Morrison

2018

Health Promot Chronic Dis Prev Can

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“…It borders seven countries and its capital is Khartoum. Sudan is a miniature representation of the diversity found in most African countries [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Congenital malformations (CM) are structural or functional anomalies that occur during intrauterine life and can be diagnosed in the prenatal period, at birth or later in life [1]. It is an important cause of perinatal morbidity and mortality, with an estimated 303,000 neonatal deaths occurring within four weeks of birth every year, worldwide [1][2][3]. CM are commonly diagnosed in late pregnancy, during the neonatal period, or during infancy [2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Profile of Prenatally Diagnosed Major Congenital Malformations in a Teaching Hospital in Nigeria

2020

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Background: Prenatal diagnosis of major congenital abnormality is one of the main goals of antenatal care, because of its contribution to perinatal morbidity and mortality. Awareness of the profile in terms of rates and spectrum could aid management and prevention strategies. This study aims to determine the profile of congenital malformations, and the relationship between the rates and some maternal socio-demographic and obstetric variables. Methods: A retrospective cross-sectional study of prenatally diagnosed congenital malformations in singleton pregnancies over a four-year period. The ultrasound scan findings and the findings of fetal ultrasonography, together with maternal socio-demographic and obstetric variables, were collected from the ultrasound scan reports or medical records of each pregnancy. Data were analyzed using Microsoft Excel 2010. Results: Among the 968 singleton pregnancies, 78 had major congenital malformation, giving an antenatal rate of 8.04/1000 (0.8%). The first trimester prevalence was comparable with other trimesters. Malformation mostly involved single systems (93.6%), which are mainly central nervous (48.7%) and gastrointestinal/abdominal systems (21.8%). The rate was statistically significant (< 0.0018) in women aged > 35 years. The mean maternal age and parity were 31.4 + 4.7 and 2.8 + 0.4, respectively. The rates of congenital malformation in spontaneously or assisted conceptions were not statistically significant (p = 0.073 and p = 0.085). Conclusion: Maternal age > 35 years and multiparity are important risk factors for congenital malformation. The commonly involved systems are the central nervous and gastrointestinal systems. Keywords: congenital malformations, prevalence, spectrum, antenatal ultrasound scan, Nigeria

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Report Summary - Congenital Anomalies in Canada 2013: A Perinatal Health Surveillance Report by the Public Health Agency of Canada’s Canadian Perinatal Surveillance System

Cited by 56 publications

References 0 publications

Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada

Incidence, Risk Factors, and Mortality Associated With Orofacial Cleft Among Children in Ontario, Canada

Childhood cancer incidence in Canada: demographic and geographic variation of temporal trends (1992–2010)

Profile of Prenatally Diagnosed Major Congenital Malformations in a Teaching Hospital in Nigeria

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