Report on optimal evaluation of the infertile male

Birmingham, Alabama

doi:10.1016/j.fertnstert.2006.08.029

Cited by 84 publications

(25 citation statements)

References 27 publications

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“…Semen analysis remains the clinical standard for assessing male fecundity and related impairments including hormone production (2), and key components such as sperm concentration, motility and morphology are reported to be capable of classifying men by fertility potential (3). The World Health Organization publishes reference values for semen parameters as derived from a compilation of largely retrospective research that represents men from various countries (4, 5).…”

Section: Introductionmentioning

confidence: 99%

Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study

Louis

Sundaram

Schisterman

et al. 2014

Fertility and Sterility

160

101

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Objective To assess semen parameters and couple fecundity as measured by time-to-pregnancy (TTP). Design Observational prospective cohort with longitudinal measurement of TTP. Setting 16 Michigan/Texas counties Participants 501 couples discontinuing contraception were followed for one year while trying to conceive; 473 (94%) men provided one semen sample and 80% provided two samples. Interventions None Main Outcome Measures Using prospectively measured TTP, fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for 36 individual semen quality parameters accounting for repeated semen samples, time off contraception, abstinence, enrollment site, and couples’ ages, body mass indices (BMI), and serum cotinine concentrations. Results In adjusted models, semen quality parameters were associated with significantly shorter TTP as measured by FORs >1: percent motility, strict and traditional morphology, sperm head width, elongation factor, and acrosome area. Significantly longer TTPs or FORs <1 were observed for morphologic categories amorphous and round sperm heads neck/midpiece abnormalities. No semen quality parameters achieved significance when simultaneously modeling all other significant semen parameters and covariates, except for percent coiled tail when adjusting for sperm concentration (FOR=0.99; 95% CI 0.99, 1.00). Male age was consistently associated with reduced couple fecundity (FOR=0.96; 95% CI 0.93–0.99) reflecting a longer TTP across all combined models. Female but not male BMI also conferred a longer TTP (FOR=0.98; 95% CI 0.96–0.99). Conclusions Several semen measures were significantly associated with TTP when modeled individually, but not jointly and in the context of relevant couple based covariates.

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Section: Introductionmentioning

confidence: 99%

Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study

Louis

Sundaram

Schisterman

et al. 2014

Fertility and Sterility

160

101

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“…A total of 200 sperm samples were analyzed. Assessment of the sperm chromatin structure assay (SCSA) was performed using flow cytometry [32]. After partial denaturation of the DNA (pH = 1.5), the samples were stained with metachromatic fluorochrome: acridine orange (Ex/Em = 488/525 and 615 nm).…”

Section: Introductionmentioning

confidence: 99%

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Growing evidence supports the reproductive and developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) from prenatal and postnatal exposure, but the results of epidemiological studies regarding harmful effects of PAHs exposure on male reproductive system still remain limited and inconclusive. The aim of the present study was to investigate the relationship between 1-hydroxypyrene, a biomarker of polycyclic aromatic hydrocarbons exposure and semen quality. Materials and Methods:The study population consisted of 277 men attending an infertility clinic for diagnostic purposes and having normal semen concentration of 20-300 mln/ml or slight oligozoospermia (semen concentration: 15-20 mln/ml) (WHO 1999). All the men were healthy and under 45 years of age. All participants were interviewed and provided a semen sample. The interview included questions concerning demographics, socio-economic status, medical history related to past diseases which may have an impact on semen quality, lifestyle factors and occupational information. Concentrations of 1-hydroxypyrene (1-OHP) in the urine samples were analyzed using high performance liquid chromatography (HPLC). Results: A positive association was found between the level of 1-OHP in urine and sperm neck abnormalities as well as the percentage of static sperm cells (p = 0.001, p = 0.018, respectively). Additionally, exposure to PAHs measured by 1-OHP in urine decreased semen volume and the percentage of motile sperm cells (p = 0.014, p = 0.0001, respectively). Conclusions: Presented findings indicate that the environmental level of PAHs exposure adversely affects male semen quality. The future large-scale studies should incorporate different biomarkers to generate a more accurate and full assessment of the effects of PAHs exposure on male fertility.

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“…An abnormal semen analysis is suggestive of testicular germ cell damage, but azoospermia may also be secondary to ejaculatory dysfunction or hormone deficiencies in survivors at risk for those complications17). When the ejaculate volume is less than 1.0 mL, the physician should perform a postejaculatory urinalysis to rule out retrograde ejaculation27).…”

Section: Assessmentmentioning

confidence: 99%

Reduced male fertility in childhood cancer survivors

Lee

Shin

2013

Ann Pediatr Endocrinol Metab

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With advances in cancer treatment, more pediatric cancer patients have increased their life expectancy. Because cancer-related therapy causes various physical and psychological problems, many male survivors experience later problems with thyroid and sexual functions, and with growth. As outcomes have improved, more survivors need to maintain their reproductive function to maximize their long-term quality of life. Cancer and cancer-related treatment can impair fertility by damage to the testes, to the hypothalamic-pituitary-gonadal axis, or to the genitourinary organs. Prior radiation therapy to the testes, the use of alkylating agents, and central hypogonadism further impair fertility in male survivors of childhood cancer. Following any course of chemotherapy, peripubertal maturation, any testicular volume changes, and symptoms of androgen deficiency should be monitored systematically. If patients request fertility testing, spermatogenesis status can be evaluated either directly by semen analysis or indirectly by determination of the levels of testosterone/gonadotropins and by monitoring any changes in testicular volume. According to the patient's condition, semen cryopreservation, hormonal therapy, or assisted reproduction technologies should be provided.

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Report on optimal evaluation of the infertile male

Cited by 84 publications

References 27 publications

Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study

Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Reduced male fertility in childhood cancer survivors

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