Report of the Scenario Planning Group for Medium Climate Change “Apple Fritters”

Tusa, Wayne; Chin, Philip A.; Tanikawa‐Oglesby, Shino

doi:10.1111/j.1749-6632.1996.tb32480.x

Cited by 1 publication

(1 citation statement)

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“…Many other matrix-free methods have been developed for laser desorption/ionization of small molecules, with potential applications in metabolomics. A variety of surface properties have been studied for matrix-free ionization of small molecules, for example: diamond nanowires [17] sol-gel derived silver-nanoparticles-impregnated thin biofilm [18], nanoporous gallium nitride-silver nanoparticles [19], metal oxide surfaces [20], nanofilament silicon [21], etc. Comprehensive reviews of innovative technologies using energy-absorbing materials for matrix-free LDI-MS have been recently published [22][23][24].…”

Section: Matrix-assisted and Matrix-free Laser Desorption/ionization Msmentioning

confidence: 99%

Direct Mass Spectrometry-Based Approaches in Metabolomics

Ibáñez

García‐Cañas

Valdés

et al. 2014

Fundamentals of Advanced Omics Technologies: From Genes to Metabolites

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Metabolomics is one of the newest omics technologies concerned with the identification and quantification of small molecules in a high-throughput manner. Considering the number of different types of metabolites present in a wide dynamic range of concentrations in any single living system, still actual analytical technologies can only capture a part of the metabolome.Currently MS-based approaches yield a higher sensitivity than NMR when analyzing minimal amounts of complex mixtures. Most MS-based approaches in metabolomics involve a physical/chemical purification/fractionation prior to MS analysis, to avoid sample matrix effects, at the expenses of low high-throughput performance. In the quest to achieve the maximum highthroughput production of metabolite information in the largest possible number of samples an extensive array of direct ionization or desorption/ionization techniques have been developed and combined. In the present Chapter an overview of the main desorption/ionization techniques coupled to MS applied to direct metabolite profiling or fingerprinting is presented.

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