Report of the Fourth International Workshop on Human Chromosome 2 Mapping 1996

Spurr, Nigel K.; Naylor, Susan L.

doi:10.1159/000134352

Cited by 42 publications

(11 citation statements)

References 14 publications

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“…To cover this region [approximately 9 cM long (Spur et al, 1996)], YAC clones from the CEPH-A and -B mega-YAC libraries were selected as initial substrates for contig construction. Based on data reported by the Whitehead Institute (WI) (http://www-genome.wi.mit.…”

Section: Construction Of An Initial Yac-based Map Of 2p15-p21mentioning

confidence: 99%

Genomic Mapping of Chromosomal Region 2p15–p21 (D2S378–D2S391): Integration of Genemap'98 within a Framework of Yeast and Bacterial Artificial Chromosomes

et al. 1999

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Section: Construction Of An Initial Yac-based Map Of 2p15-p21mentioning

confidence: 99%

Genomic Mapping of Chromosomal Region 2p15–p21 (D2S378–D2S391): Integration of Genemap'98 within a Framework of Yeast and Bacterial Artificial Chromosomes

et al. 1999

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“…The 2q13 breakpoint was Localized by interphase FlSH within YACs 989f12 and 896a8 and BAC 110L24, which contained the PAX8 gene. The 2q13 map is based on data from the WhiteheadIMassachusetts Institute of Technology Center for Genome Research and chromosome 2 mapping efforts (23). (B) BAC 110L24 crosses the 2q13 breakpoint.…”

mentioning

confidence: 99%

PAX8-PPAR γ 1 Fusion in Oncogene Human Thyroid Carcinoma

Kroll

Sarraf

Pecciarini

et al. 2000

Science

768

536

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Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma1. PAX8-PPARgamma1 mRNA and protein were detected in 5 of 8 thyroid follicular carcinomas but not in 20 follicular adenomas, 10 papillary carcinomas, or 10 multinodular hyperplasias. PAX8-PPARgamma1 inhibited thiazolidinedione-induced transactivation by PPARgamma1 in a dominant negative manner. The experiments demonstrate an oncogenic role for PPARgamma and suggest that PAX8-PPARgamma1 may be useful in the diagnosis and treatment of thyroid carcinoma.

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“…The cloning of genes from 2p15-p16, which is flanked by genetic markers D2S119 (telomeric) and D2S147 (centromeric) (26), has been hindered by two gaps of unknown size in the publicly available genomic maps [GenBank and Whitehead Institute, Massachusetts Institute of Technology (WI/MIT)] (Refs. 2 and 13, respectively).…”

mentioning

confidence: 99%