Report of the committee on chromosome and gene loss in human neoplasia

Clinical Implications of p57KIP2Expression in Breast Cancer

“…At the same time, P57 KIP2 has been used as a predictive factor, to differentiate periods in many kinds of tumors. There have been reports that P57 KIP2 undergoes frequent loss of heterozygosity in breast, bladder, lung, ovarian, kidney, and testicular carcinomas (Seizinger et al, 1991) . The p57 gene is paternally imprinted in humans , and loss of the maternal (expressed) allele occurs in a variety of pediatric tumors, including Wilms' tumor (Hatada et al, 1996), and in adult lung tumors (Kondo et al, 1996).…”

An Ordered NotI Fragment Map of Human Chromosome Band 11p15

“…Furthermore, uniparental disomy for I1p15.5 markers has been demonstrated in some sporadic cases ofBWS . While other explanations exist, the specific loss of maternal I1p15 alleles in pediatric turnors is also consistent with genomic imprinting (Seizinger et al} 1991). Genomic imprinting has been implicated in HLA-DR4-dependent diabetes susceptibility (Julier et al, 1991), a condition that maps at or very close to the INSIIGF2 locus.…”

“…Loss ofheterozygosity (LOH) studies of the childhood tumors associated with BWS and their sporadic counterparts demonstrate a consistent loss of alleles in 11p15, with the shortest region of overlap for rhabdomyosarcoma and Wilms tumor being Dl1S12 to pter (Scrableet al, 1987;Coppes et al, 1992). Significantly, several adult turnors, including breast cancer and bladder, testicular, and ovarian carcinoma (reviewed in Seizinger et al, 1991), also exhibit LOH in this same region, which has now been named multiple tumor associated chromosome region 1 (MTACRl). Further support for the existence of a tumor (growth) suppressor gene(s) in 11p15 comes from chromosome transfer experiments in rhabdomyosarcoma and rhabdoid tumor cell lines (Dowdy et al, 1991;Loh et al, 1992;Koi et al, 1993).…”

Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22

“…Such studies should also elucidate the relationship between RCC tumour-suppressor genes and the molecular pathology of other human cancers, such as lung, breast, ovary, uterus and testis cancer, which show frequent chromosome 3p allele loss (Seizinger et al, 1991b).…”