Report of the committee on the genetic constitution of chromosome 3

Naylor, Susan L.; Bishop, D. Timothy

doi:10.1159/000132648

Cited by 21 publications

(13 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The critical region in RCC appears tobe 3pI3-p14.2, while the region of3pl4-p23 appears to be important in SCC (54,55). This region of 3p(p21-p14) has recently been reported to contain a ras-related gene, ARH12 (56).…”

Section: Methodsmentioning

confidence: 99%

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

View full text Add to dashboard Cite

show abstract

“…The most distant deleted loci, D3S22 and D3S18 are 19 cM apart, defining the minimum length of the deletion in TR. The deletion in this patient, which is circumscribed by the c-raf-1 and D3S17 loci, is less than 30 cM in length [Donis-Keller et al, 1987;Naylor and Bishop, 1989;Hosoe et al, 1990;Tory et al, 19911.…”

mentioning

confidence: 99%

Clinical and molecular analyses of deletion 3p25‐pter syndrome

et al. 1993

View full text Add to dashboard Cite

Hemizygous deletion of 3p25-pter is associated with a phenotype of profound growth failure, microcephaly, characteristic facial changes, and mental retardation. Since the severity may be quite variable, we have studied 3 cases of del 3p25-pter to define the clinical manifestations and the critical chromosome region for phenotypic expression. The patient we now report died at age 6 months and provided an opportunity for a detailed necropsy analysis for only the second time in a del(3p) patient. He had marked hypoplasia of all organs, hypomyelination of white matter, and multiple renal cortical microcysts. Ordered genomic markers from the distal regions of chromosome 3p aided in determining the parent of origin of each deletion and in defining the boundaries of the deleted chromosomal segments. The deleted markers distal to the RAF1 oncogene in 2 of the 3 patients were consistently hemizygous. One patient had an interstitial deletion based on evidence of diploid inheritance of one of the most distal loci (D3S17). Available genetic linkage maps suggest that the deletion spans at least 19 centimorgans (cM).

show abstract

“…as so few common markers have been used. When a framework col lection was described at the Eleventh International Workshop on Human Gene Mapping (Naylor and Carritt, 1991), only 21 markers met the requirement of an unambiguous order, and many of these markers had unknown or poorly defined chro mosomal locations. The work presented here demonstrates the successful application of multicolour FISH to the ordering and precise localisation of several single-copy DNA probes for small targets on metaphase chromosomes and, as such, illus trates a powerful method for increasing and improving any ref erence collection of framework markers.…”

Section: Discussionmentioning

confidence: 99%

Multicolour fluorescence in situ hybridisation to order small, single-copy probes on metaphase chromosomes

Heppell-Parton¹,

Albertson

Rabbitts³

1994

Cytogenet Genome Res

View full text Add to dashboard Cite

In constructing complete human chromosome maps, the relative order of markers and their precise chromosomal location will be combined. Multicolour in situ hybridisation, in which two probes are simultaneously hybridised to chromosomes and subsequently distinguished, potentially will provide both types of information. Using this technique, we have produced an ordered map of eight human chromosome 3 DNA markers, using small, single-copy probes that can detect target sequences ranging in size from 4 kb to as little as 500 bp.

show abstract

Report of the committee on the genetic constitution of chromosome 3

Cited by 21 publications

References 6 publications

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Clinical and molecular analyses of deletion 3p25‐pter syndrome

Multicolour fluorescence in situ hybridisation to order small, single-copy probes on metaphase chromosomes

Contact Info

Product

Resources

About