Report of a rare and aggressive case of oral malignant melanoma

Ahmadi‐Motamayel, Fatemeh; Falsafi, Parisa; Baghaei, Fariba

doi:10.1007/s10006-012-0311-3

Cited by 11 publications

(16 citation statements)

References 11 publications

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“…Specific tumor markers such as S-100, Melan-A, HMB-45 and Ki-67 are used for the differential diagnosis of melanoma. However, the clinical and histopathological evidence of the present case rules out any possibility of doubtful interpretation of the diagnosis, differing clearly from the pigmented lesions found in Addison's disease, Peutz-Jeghers syndrome, Kaposi's sarcoma, amalgam tattoo, nevus, melanotic pigmentation, and melanoacanthoma 14 .…”

Section: Discussioncontrasting

confidence: 65%

Melanoma of the oral mucosa: report of an aggressive case and review of the literature

Dias¹,

Filho²,

Pereira³

et al. 2017

J Oral Diag

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Introduction: Melanoma is an aggressive malignant neoplasm of uncertain etiology. Although the third most common skin cancer, melanoma is rare in the oral cavity, accounting for less than 1% of all melanomas and for 0.5% of all malignant oral tumors. Objective:This study reports a case of melanoma diagnosed and followed up by the dentistry team of the Napoleão Laureano Hospital, João Pessoa, Paraíba, Brazil. Case report: A 69-year--old dark-skinned male patient was referred to the stomatology service of the hospital reporting pain and bleeding in the upper alveolar ridge, as well as the presence of a "lump" at the same site. Intraoral physical examination revealed a purple nodule of soft consistency in the anterior maxilla, which measured 2.0 cm in diameter and exhibited superficial ulcerations. An incisional biopsy was performed and histopathological analysis revealed intense proliferation of atypical melanocytes characterized by variable degrees of pleomorphism and nuclear hyperchromatism. The diagnosis was melanoma of the oral mucosa. The patient underwent surgical resection consisting of complete removal of the tumor with wide safety margins, chemotherapy, and adjuvant radiotherapy. The patient continues under follow-up and showed no recurrence of the lesion one year after surgery. Conclusion: Melanoma of the oral mucosa exhibits an aggressive behavior and rapid growth, as observed in the present case. Knowledge of the clinical and etiopathogenic features is important for the early diagnosis of the disease in order to improve patient survival.

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Section: Discussioncontrasting

confidence: 65%

Melanoma of the oral mucosa: report of an aggressive case and review of the literature

Dias¹,

Filho²,

Pereira³

et al. 2017

J Oral Diag

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“…Oral melanomas show slightly more male predilection (2 : 1) [ 1 , 13 , 14 , 19 ]. And incidence is more common in whites than blacks [ 6 , 10 ]. Commonly involved intraoral sites are hard palate (32%), maxillary gingiva (16%), mandibular gingiva (7%), tongue (7%), buccal mucosa (7%), and upper and lower lip (7%) [ 6 , 9 , 10 , 13 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Three criteria have been proposed by Gupta et al that can be helpful in the diagnosis of primary oral melanoma. These include presence of malignant melanoma in the oral mucosa; the exclusion of melanoma at any other primary site; and histopathologic observation of “junctional activity” which is described as melanocytes arranged along the basal layer of the surface epithelium 1 [ 4 , 7 , 8 , 10 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of Maxilla: Report of a Case with Discussion

Rani

Kumar²,

Kolasani

et al. 2014

Case Reports in Dentistry

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Primary oral malignant melanoma, very rare neoplasm of melanocytic origin, usually presents as a bluish black to tan-brown colored lesion Which is accounting for 0.2 to 8% of all melanomas, 1.6% of all head and neck malignancies, and 0.5% of all oral neoplasia. In general, the prognosis of oral melanoma is poor and worse than that of cutaneous melanoma. Here a case of oral malignant melanoma is presented, which was undetected during the first visit to a dental clinic. When a simple oral surgical treatment was carried out in that region, it resulted in the appearance of a massive pigmented lesion which was histopathologically diagnosed as malignant melanoma. This paper is presented to reemphasize the fact that any pigmented lesion in the oral cavity should be viewed with suspicion and proper investigation (biopsy) should be carried out to rule out any untoward experiences later.

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“…Often at this stage, they present as an ulcerated, painful, and bleeding swellings. [5,8,9] The reported patient in our case, presented with a tumour 5x4 cm involving submandibular lymph node. Management of aggressive tumours that are diagnosed at advanced stage present significant challenges, requiring more expertise, and resources, and the prognosis of the patient may not be favourable.…”

Section: Discussionmentioning

confidence: 83%

“…Globally, oral malignant melanomas have an incidence rate of 0.2% [5] to 8% [4] and account for 1.6% of all head and neck cancers, [5] 2% of all mucocutaneous melanomas [6] and 0.5% of all oral malignancies. [6] About 80% of all oral melanomas occur on the mucosa of the upper jaw.…”

Section: Introductionmentioning

confidence: 99%

Oral Malignant melanoma in an HIV patient

Mumena¹

2019

Rwanda Journal of Medicine and Health Sciences

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Oral malignant melanomas are aggressive tumors in head and neck region, rarely seen in HIV patients. By suppressing immunity, HIV might be increasing the severity of malignant tumors. Oral malignant melanomas are associated with poor prognosis, due to their aggressiveness. Of clinical importance, the prognosis of oral malignant melanomas in HIV patient is still not well understood. Presented is a 44-year-old female, HIV seropositive with a swelling on the lower lip for five months. Management involved antiretroviral therapy, surgical excision of the lesion and regional lymph nodes, with chemotherapy. Avoidance of preoperative insult and aggressive therapy offers a relatively better prognosis. Irrespective of lesion size, aggressive treatment is needed for oral malignant melanoma.

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Report of a rare and aggressive case of oral malignant melanoma

Cited by 11 publications

References 11 publications

Melanoma of the oral mucosa: report of an aggressive case and review of the literature

Melanoma of the oral mucosa: report of an aggressive case and review of the literature

Primary Malignant Melanoma of Maxilla: Report of a Case with Discussion

Oral Malignant melanoma in an HIV patient

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