Report Of A False Positive Rapid HIV Test Due To Hepatitis A In A U.S. Army Soldier

Abstract

A 25 year old, single, active duty soldier presented to a clinic in Afghanistan complaining of malaise, fatigue, acholic stools, and mild jaundice over a 5-to 7-day period. He had significantly elevated liver transaminase levels approaching 5000 U/L and a positive rapid human immunodeficiency (HIV) 1 antibody test. Ultimately, the patient was found to have a false positive rapid HIV-1 antibody test due to acute hepatitis A virus infection. This case report describes his evaluation and outcome, in addition to exploring possible causes of false positive HIV screening.

False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies

“…These include high concentrations of biotin often used as a dietary supplement, which interfere with streptavidin–biotin interactions in detection systems [ 2 ], as well as pregnancy [ 3 ], autoimmune disease [ 4 ], cancer [ 5 ], vaccination against influenza [ 6 ] or rubella virus [ 7 ], and receipt of blood donations [ 8 ]. Furthermore, infections with different protozoa, bacteria, and viruses, including Epstein–Barr virus (EBV) [ 9 ], hepatitis A [ 10 ] and B [ 11 ], measles [ 12 ], and dengue virus [ 13 ] have been linked to HIV diagnostic malperformance.…”