“…There are case reports of an affected mother and children (Hendricks & Sybert, 1991;Jackson & Apostolides, 1978;MacFadyen & Young, 1987;Rogers et al, 1993). Affected siblings have been reported as well (Claviez et al, 1995;Lainakis et al, 2005;Montgomery et al, 1971). In addition, AP has also been associated with syndromes such as Down syndrome (Stoll et al, 2015;Torfs & Christianson, 1998), Jacobsen syndrome (Fernandez Gonzalez et al, 2002), VACTERL (Reutter et al, 2014), 1p36 deletion syndrome (Minami et al, 2005), Mitchell-Riley syndrome (Zegre Amorim et al, 2015), and 22q11.2 deletion (Spineli-Silva et al, 2018).…”