Repopulation of the Retinal Pigment Epithelium After Pigment Epithelial Rip

Peiretti, Enrico; Iranmanesh, Reza; Lee, Jong Jian; Klancnik, James M.; Sorenson, John A.; Yannuzzi, Lawrence A.

doi:10.1097/01.iae.0000233328.68999.5f

Cited by 22 publications

(18 citation statements)

References 4 publications

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“…Repopulation of the RPE after retinal pigment tear documented with OCT has recently been described [12]. Similarly, in our case OCT clearly documented RPE margin reattachment, corresponding to a hyperreflective RPE band (fig.…”

Section: Discussionsupporting

confidence: 53%

“…Peiretti et al [12 ]described some peculiar AF findings at the site of the tear and assumed that hyper-AF may indicate a curled or redundant RPE layer. In our case there was a band of hyper-AF along the upper edge of the lesion (fig.…”

Section: Discussionmentioning

confidence: 99%

“…The pattern and course of RPE tears have been studied in the past by fluorescein fundus angiography, autofluorescence (AF), fundus ophthalmoscopy, stereo colour photography and more recently by optical coherence tomography (OCT) [8,9,10,11,12,13]. Hoskin et al [1 ]described the fluorescein findings of reattachment of the free margin to Bruch’s membrane, a few days or weeks after the tear.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Reattachment of the Margins of a Macular Retinal Pigment Epithelium Tear: Optical Coherence Tomography Documentation of a Case

et al. 2009

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Purpose: To document by optical coherence tomography (OCT) the reattachment of the margins of a retinal pigment epithelium (RPE) tear. Methods: Single case report, documented by OCT scans, autofluorescence and fluorescein angiography. Results: A 67-year-old male presented with a spontaneous RPE tear due to age-related macular degeneration in his right eye. Three months later we observed that the focal RPE tear had healed and there was a new intraretinal fluid, well documented by OCT imaging. Conclusions: OCT scans show the reattachment of the margins of an RPE tear healed by tissue remodelling, and illustrate how the disease can recur.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spontaneous Reattachment of the Margins of a Macular Retinal Pigment Epithelium Tear: Optical Coherence Tomography Documentation of a Case

et al. 2009

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“…After a RPE rip occurs, RPE proliferation is activated that can repair the initial RPE layer defect. 58 In contrast to atrophic retinal diseases such as dry AMD which have limited RPE proliferation, more robust RPE proliferation occurs in proliferative retinal disease. For example, after retinal detachment, massive proliferation of the RPE can occur with associated EMT and growth of epiretinal membranes.…”

Section: Rpe Cell Proliferation In Vivomentioning

confidence: 99%

Retinal pigment epithelial cell proliferation

Stern

Temple

2015

Exp Biol Med (Maywood)

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The human retinal pigment epithelium forms early in development and subsequently remains dormant, undergoing minimal proliferation throughout normal life. Retinal pigment epithelium proliferation, however, can be activated in disease states or by removing retinal pigment epithelial cells into culture. We review the conditions that control retinal pigment epithelial proliferation in culture, in animal models and in human disease and interpret retinal pigment epithelium proliferation in context of the recently discovered retinal pigment epithelium stem cell that is responsible for most in vitro retinal pigment epithelial proliferation. Retinal pigment epithelial proliferation-mediated wound repair that occurs in selected macular diseases is contrasted with retinal pigment epithelial proliferation-mediated fibroblastic scar formation that underlies proliferative vitreoretinopathy. We discuss the role of retinal pigment epithelial proliferation in age-related macular degeneration which is reparative in some cases and destructive in others. Macular retinal pigment epithelium wound repair and regression of choroidal neovascularization are more pronounced in younger than older patients. We discuss the possibility that the limited retinal pigment epithelial proliferation and latent wound repair in older age-related macular degeneration patients can be stimulated to promote disease regression in age-related macular degeneration.

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“…Different treatment protocols and follow-up periods may explain the wide incidence range and difficulties in diagnosing RPE tears. In previous case studies, the spontaneous healing of RPE tears has been demonstrated by using time-domain OCT (10,11) . In a study conducted by Caramoy et al, the use of anti-VEGFs was proposed to slow down the scarring process, prevent photoreceptor damage, and give RPE a chance to heal (12) .…”

Section: Introductionmentioning

confidence: 99%

Anatomical and visual outcomes of ranibizumab injections in retinal pigment epithelium tears

Erol¹,

Özdemir²,

Çoban³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: To report the anatomical and visual results in patients diagnosed as having retinal pigment epithelium (RPE) tears after receiving ranibizumab injections. Methods: Eyes diagnosed as having RPE tears with a minimum 6-month follow-up were retrospectively evaluated. Each eye was treated with at least three doses of ranibizumab at monthly intervals. Best-corrected visual acuity (BCVA), anterior segment findings, intraocular pressure, and fundus examination results were evaluated during control visits. Color fundus photography, fundus fluorescein angiographies, fundus autofluorescence, and spectral domain optical coherence tomography (SD-OCT) images were obtained. The height of pigment epithelial detachment (PED) was measured by SD-OCT. Results: Twelve eyes with RPE tears were studied. Nine eyes (75%) developed RPE tears during ranibizumab injections for choroidal neovascularization (eight eyes with vascularized PED and one eye with choroidal osteoma), and tears occurred in three eyes before any injections. The median number of ranibizumab injections after diagnosis of RPE tears was 3 (min 2, max 5). In the most recent follow-up visit, there was no statistically significant correlation between the grade of RPE and logMAR of BCVA (p>0.05, r=0.112). Eight of twelve eyes had PED, and seven of these had irregular PED contours before injection therapy. The mean PED height was 447 ± 122 µm. Conclusions: In this series, RPE tears developed mostly after intravitreal anti-VEGF injections for vascularized PED. Increased vertical height and irregular contours of the PEDs can be risk factors for the formation of RPE tears. The continuation of anti-VEGF therapy after tear formation is beneficial for vision improvement in eyes with RPE tears. Keywords

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Repopulation of the Retinal Pigment Epithelium After Pigment Epithelial Rip

Abstract: Edited by Lee M. Jampol Repopulation of the Retinal Pigment EpitheliumAfter Pigment Epithelial Rip center of the fovea. In short, the OCT image supports the concept of repopulation of hypopigmented RPE and reconstitution of the posterior blood-retinal barrier after an RPE rip.

Cited by 22 publications

References 4 publications

Spontaneous Reattachment of the Margins of a Macular Retinal Pigment Epithelium Tear: Optical Coherence Tomography Documentation of a Case

Spontaneous Reattachment of the Margins of a Macular Retinal Pigment Epithelium Tear: Optical Coherence Tomography Documentation of a Case

Retinal pigment epithelial cell proliferation

Anatomical and visual outcomes of ranibizumab injections in retinal pigment epithelium tears

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