Réponse de F. Leung, J.-J. Terzibachian et D. Riethmuller à l’article de M. Saim et al.

Leung, F.; Terzibachian, J.-J.; Riethmuller, Didier

doi:10.1016/j.gyobfe.2008.06.010

Cited by 4 publications

(6 citation statements)

References 5 publications

(2 reference statements)

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“…The mutated receptor is associated with cataract, spina bifida and white belly spot phenotypes in mice [1232]. Gene disruption is associated with a failure of asymmetric embryonic development in zebrafish [1362].…”

Section: Commentsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2021

British J Pharmacology

376

274

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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: Commentsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2021

British J Pharmacology

376

274

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“…A summary of other important interactions is highlighted in Table 1. Extensive reviews and reports have previously been published on interactions that influence clozapine metabolism (eg, via CYP1A2, CYP2C19, CYP2D6, CYP3A4) 49,54–59 …”

Section: Clozapine and Remsmentioning

confidence: 99%

The Modernization of Clozapine

Leung

León²,

Frye

et al. 2022

J Clin Psychopharmacol

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Purpose: Although clozapine was Food and Drug Administration (FDA) approved more than 3 decades ago, major barriers and gaps in knowledge continue to prevent its effective and safe use. We review modern-day problems encountered with clozapine in the United States (US).Methods: Information surrounding current administrative, clinical, research, and technological gaps or barriers related to clozapine use in the US was reviewed. Findings:The history of how clozapine became FDA approved likely contributes to gaps in knowledge. The frequency of safety warnings added to the FDA prescribing information may add to fears about clozapine, as evidence by numerous published survey studies. The clozapine Risk Evaluation and Mitigation Strategy (REMS) program has been modified several times in the last decade, causing access and safety issues for patients, which are discussed. Evidence may suggest that the FDA REMS requirements for hematologic monitoring are too cumbersome, and there may be ability to safely loosen requirements. The COVID-19 pandemic brought forth the ability for extended interval monitoring but also greater awareness of the clozapine-inflammation interaction. Newer guidelines published describe considerations in personalizing clozapine titration based on principles of ethnopsychopharmacology. Emerging technologies to support the use of clozapine are not widely available.Implications: Clozapine is a unique life-saving drug but it is underused in the US, despite its established efficacy. The 2021 REMS changes led to significant difficulties for providers and patients. We highlight the importance of the clozapine-inflammation interaction, therapeutic drug monitoring, and the ability for individual care based on patient-specific factors. There is an urgent need for advancing technology used for clozapine monitoring, evaluating barriers created by REMS, and establishing consistent practices throughout the US.

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“…3 The evolution of magnetoelectricity has called for broadband general detection of magnetic fields and electric currents on the one hand and for narrowband precision detection on the other hand. 4 Hence, it is of great scientific and practical values if the non-resonance and resonance S I of our developed MER can be utilized to configure a broadband sensing mode for general detection and a narrowband transduction mode for precision detection, both in concurrent operation.…”

mentioning

confidence: 99%

“…Details of the fabrication of the MER and the magnetostrictive composite rings can be found elsewhere. 3,5 The PET is a Rosen-type PZT piezoelectric ceramic transformer of length (l 1 þ l 2 ) 27 mm, width (w) 8 mm, and thickness (t) 1.8 mm in order to match its fundamental longitudinal resonance frequency with the fundamental radial resonance frequency of the MER for maximizing a)…”

mentioning

confidence: 99%

“…7 Due to the nonuniform distribution of H over the volume of the MER, an average ac vortex magnetic field (H avg ) is detected by the MER which, in turn, causes the top and bottom magnetostrictive composite rings to produce radial (r) motions based on the magnetostrictive effect. 3 Because of the mechanical coupling, the induced magnetostrictive strains lead to stresses in the central piezoelectric ceramic ring, thereby producing an ac piezoelectric voltage (V CSM ) across the thickness of the piezoelectric ceramic ring based on the piezoelectric effect. This V CSM corresponds to the magnetoelectric voltage output from an individual MER (V MER ), provided that the output impedance of the MER is much smaller than the input impedance of the PET.…”

mentioning

confidence: 99%

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Concurrent operational modes and enhanced current sensitivity in heterostructure of magnetoelectric ring and piezoelectric transformer

Zhang

Leung

Kuang

et al. 2013

Journal of Applied Physics

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A heterostructure possessing two concurrent operational modes: current sensing (CS) mode and current transduction (CT) mode and an enhanced current sensitivity associated with the CT mode is proposed by combining a magnetoelectric ring (MER) with a piezoelectric transformer (PET). The MER is a ring-shaped magnetoelectric laminate having an axially polarized Pb(Zr, Ti)O3 (PZT) piezoelectric ceramic ring sandwiched between two circumferentially magnetized, inter-magnetically biased Tb0.3Dy0.7Fe1.92 (Terfenol-D) short-fiber/NdFeB magnet/epoxy three-phase magnetostrictive composite rings, while the PET is a Rosen-type PZT piezoelectric ceramic transformer. The current sensitivity (SI) and magnetoelectric voltage coefficient (αV) of the heterostructure in the two operational modes are evaluated theoretically and experimentally. The CS mode provides a large SI of ∼10 mV/A over a flat frequency range of 10 Hz−40 kHz with a high resonance SI of 157 mV/A at 62 kHz. The CT mode gives a 6.4-times enhancement in resonance SI, reaching 1000 mV/A at 62 kHz, as a result of the amplified vortex magnetoelectric effect caused by the vortex magnetoelectric effect in the MER, the matching of the resonance frequencies between the MER and the PET, and the resonance voltage step-up effect in the PET.

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Réponse de F. Leung, J.-J. Terzibachian et D. Riethmuller à l’article de M. Saim et al.

Cited by 4 publications

References 5 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

The Modernization of Clozapine

Concurrent operational modes and enhanced current sensitivity in heterostructure of magnetoelectric ring and piezoelectric transformer

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