Reply to the article entitled “Impact of assay design on test performance: lessons learned from 25-hydroxyvitamin D” by Farrell et al., Clin Chem Lab Med 2014;52:1579–87
Abstract:Keywords: 25-hydroxyvitamin D; 25-OHD; automated 25-OHD assay; liquid chromatography-tandem mass spectrometry (LC-MS/MS).To the Editor, In the recent article by Farrell et al. [1], the authors explain the variability in results of various vitamin D (25-OHD) immunoassays based on specific aspects of assay design. Here, we question their interpretation of the conclusion.The authors attempt to explain the variation in results obtained with commercial 25-OHD assays. To test their hypotheses, they conducted studies… Show more
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