Reply to Tall et al.:
            <i>Dictyostelium</i>
            Ric8 does not have a chaperoning function during development and chemotaxis

Kataria, Rama; Haastert, Peter J.M. van; Kortholt, Arjan

doi:10.1073/pnas.1309837110

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2016

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“…It thereby amplifies and extends the G protein signal. In contrast to mammalian Ric8, there is so far no evidence that Dictyostelium Ric8 in addition has a role as a chaperone for Gα proteins [ 51 ]. Both in mammals and in Dictyostelium , the regulation of Ric8 is still not completely understood.…”

Section: Regulation Of Gpcrs and Heterotrimeric G Proteins During mentioning

confidence: 99%

Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

Kamp¹,

Liu²,

Kortholt³

2016

IJMS

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Chemotaxis, or directional movement towards an extracellular gradient of chemicals, is necessary for processes as diverse as finding nutrients, the immune response, metastasis and wound healing. Activation of G-protein coupled receptors (GPCRs) is at the very base of the chemotactic signaling pathway. Chemotaxis starts with binding of the chemoattractant to GPCRs at the cell-surface, which finally leads to major changes in the cytoskeleton and directional cell movement towards the chemoattractant. Many chemotaxis pathways that are directly regulated by Gβγ have been identified and studied extensively; however, whether Gα is just a handle that regulates the release of Gβγ or whether Gα has its own set of distinct chemotactic effectors, is only beginning to be understood. In this review, we will discuss the different levels of regulation in GPCR signaling and the downstream pathways that are essential for proper chemotaxis.

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Section: Regulation Of Gpcrs and Heterotrimeric G Proteins During mentioning

confidence: 99%